Cortical network organization reflects clinical response to
subthalamic nucleus deep brain stimulation in Parkinson's
disease

J 2021

Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease

BOČKOVÁ, Martina, Eva VÝTVAROVÁ, Martin LAMOŠ, P. KLIMES, P. JURAK et. al.

Základní údaje

Originální název

Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease

Autoři

BOČKOVÁ, Martina (203 Česká republika, domácí), Eva VÝTVAROVÁ (203 Česká republika, domácí), Martin LAMOŠ (203 Česká republika, domácí), P. KLIMES, P. JURAK, J. HALAMEK, Sabina GOLDEMUNDOVÁ (203 Česká republika, domácí), Marek BALÁŽ (703 Slovensko, domácí) a Ivan REKTOR (203 Česká republika, garant, domácí)

Vydání

Human Brain mapping, Hoboken, WILEY-BLACKWELL, 2021, 1065-9471

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.399

Kód RIV

RIV/00216224:14740/21:00119591

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1002/hbm.25642

UT WoS

000689718000001

Klíčová slova anglicky

deep brain stimulation; high-density EEG; network analysis; subthalamic nucleus

Štítky

14110127, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 10. 2024 12:29, Ing. Jana Kuchtová

Anotace

V originále

The degree of response to subthalamic nucleus deep brain stimulation (STN-DBS) is individual and hardly predictable. We hypothesized that DBS-related changes in cortical network organization are related to the clinical effect. Network analysis based on graph theory was used to evaluate the high-density electroencephalography (HDEEG) recorded during a visual three-stimuli paradigm in 32 Parkinson's disease (PD) patients treated by STN-DBS in stimulation "off" and "on" states. Preprocessed scalp data were reconstructed into the source space and correlated to the behavioral parameters. In the majority of patients (n = 26), STN-DBS did not lead to changes in global network organization in large-scale brain networks. In a subgroup of suboptimal responders (n = 6), identified according to reaction times (RT) and clinical parameters (lower Unified Parkinson's Disease Rating Scale [UPDRS] score improvement after DBS and worse performance in memory tests), decreased global connectivity in the 1-8 Hz frequency range and regional node strength in frontal areas were detected. The important role of the supplementary motor area for the optimal DBS response was demonstrated by the increased node strength and eigenvector centrality in good responders. This response was missing in the suboptimal responders. Cortical topologic architecture is modified by the response to STN-DBS leading to a dysfunction of the large-scale networks in suboptimal responders.

Návaznosti

GA21-25953S, projekt VaV

Název: Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace (Akronym: DBS3D)

Investor: Grantová agentura ČR, Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace

NU21-04-00445, projekt VaV

Název: Klinická odpovídavost na STN-DBS u Parkinsonovy nemoci: vliv vaskulárních, kardiovaskulárních, metabolických a zánětlivých komorbidit (Akronym: DBScomorbidities)

Investor: Ministerstvo zdravotnictví ČR, Klinická odpovídavost na STN-DBS u Parkinsonovy nemoci: vliv vaskulárních, kardiovaskulárních, metabolických a zánětlivých komorbidit, Podprogram 1 - standardní

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

BOČKOVÁ, Martina, Eva VÝTVAROVÁ, Martin LAMOŠ, P. KLIMES, P. JURAK, J. HALAMEK, Sabina GOLDEMUNDOVÁ, Marek BALÁŽ a Ivan REKTOR. Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease. Human Brain mapping. Hoboken: WILEY-BLACKWELL, 2021, roč. 42, č. 17, s. 5626-5635. ISSN 1065-9471. Dostupné z: https://dx.doi.org/10.1002/hbm.25642.

@article{1823377,
   author = {Bočková, Martina and Výtvarová, Eva and Lamoš, Martin and Klimes, P. and Jurak, P. and Halamek, J. and Goldemundová, Sabina and Baláž, Marek and Rektor, Ivan},
   article_location = {Hoboken},
   article_number = {17},
   doi = {http://dx.doi.org/10.1002/hbm.25642},
   keywords = {deep brain stimulation; high-density EEG; network analysis; subthalamic nucleus},
   language = {eng},
   issn = {1065-9471},
   journal = {Human Brain mapping},
   title = {Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/hbm.25642},
   volume = {42},
   year = {2021}
}

TY  - JOUR
ID  - 1823377
AU  - Bočková, Martina - Výtvarová, Eva - Lamoš, Martin - Klimes, P. - Jurak, P. - Halamek, J. - Goldemundová, Sabina - Baláž, Marek - Rektor, Ivan
PY  - 2021
TI  - Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease
JF  - Human Brain mapping
VL  - 42
IS  - 17
SP  - 5626-5635
EP  - 5626-5635
PB  - WILEY-BLACKWELL
SN  - 10659471
KW  - deep brain stimulation
KW  - high-density EEG
KW  - network analysis
KW  - subthalamic nucleus
UR  - https://onlinelibrary.wiley.com/doi/10.1002/hbm.25642
N2  - The degree of response to subthalamic nucleus deep brain stimulation (STN-DBS) is individual and hardly predictable. We hypothesized that DBS-related changes in cortical network organization are related to the clinical effect. Network analysis based on graph theory was used to evaluate the high-density electroencephalography (HDEEG) recorded during a visual three-stimuli paradigm in 32 Parkinson's disease (PD) patients treated by STN-DBS in stimulation "off" and "on" states. Preprocessed scalp data were reconstructed into the source space and correlated to the behavioral parameters. In the majority of patients (n = 26), STN-DBS did not lead to changes in global network organization in large-scale brain networks. In a subgroup of suboptimal responders (n = 6), identified according to reaction times (RT) and clinical parameters (lower Unified Parkinson's Disease Rating Scale [UPDRS] score improvement after DBS and worse performance in memory tests), decreased global connectivity in the 1-8 Hz frequency range and regional node strength in frontal areas were detected. The important role of the supplementary motor area for the optimal DBS response was demonstrated by the increased node strength and eigenvector centrality in good responders. This response was missing in the suboptimal responders. Cortical topologic architecture is modified by the response to STN-DBS leading to a dysfunction of the large-scale networks in suboptimal responders.
ER  -

BOČKOVÁ, Martina, Eva VÝTVAROVÁ, Martin LAMOŠ, P. KLIMES, P. JURAK, J. HALAMEK, Sabina GOLDEMUNDOVÁ, Marek BALÁŽ a Ivan REKTOR. Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease. \textit{Human Brain mapping}. Hoboken: WILEY-BLACKWELL, 2021, roč.~42, č.~17, s.~5626-5635. ISSN~1065-9471. Dostupné z: https://dx.doi.org/10.1002/hbm.25642.

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