Repetitive transcranial magnetic stimulation in borderline
personality disorder: clinical and brain connectivity changes

a 2021

Repetitive transcranial magnetic stimulation in borderline personality disorder: clinical and brain connectivity changes

LINHARTOVÁ, Pavla, Tomáš SVĚRÁK, Martin GAJDOŠ a Tomáš KAŠPÁREK

Základní údaje

Originální název

Repetitive transcranial magnetic stimulation in borderline personality disorder: clinical and brain connectivity changes

Autoři

LINHARTOVÁ, Pavla (203 Česká republika, garant, domácí), Tomáš SVĚRÁK (203 Česká republika, domácí), Martin GAJDOŠ (203 Česká republika, domácí) a Tomáš KAŠPÁREK (203 Česká republika, domácí)

Vydání

4th International Brain Stimulation Meeting, December 6-9, 2021, Charleston, SC USA, 2021

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30215 Psychiatry

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14110/21:00120216

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.brs.2021.10.292

Klíčová slova anglicky

rTMS; borderline personality disorder; impulsivity; brain connectivity

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 5. 2022 10:09, Mgr. Tereza Miškechová

Anotace

V originále

Introduction: Repetitive transcranial magnetic stimulation (rTMS) is an innovative method in the treatment of BPD. Only several studies so far explored the effect of rTMS on BPD symptoms. We hypothesized that prefrontal rTMS in patients with BPD leads to improvement of symptoms with specific brain connectivity changes. Method: Fourteen patients with BPD received 15 sessions of individually navigated prefrontal rTMS over the right dorsolateral prefrontal cortex. Clinical effect was measured by Borderline Symptom List 23 (BSL-23), UPPS-P impulsive behavior scale, Difficulties in emotion regulation scale (DERS), Zung self-reported anxiety scale (SAS), and Montgomery and Åsberg Depression Rating Scale (MADRS). Brain connectivity changes after rTMS were assessed with seed connectivity analysis at resting-state fMRI and with beta series connectivity analysis during an fMRI Go/No Go task. Results: Comparison after vs. before rTMS showed a significant decrease in impulsivity, emotion dysregulation, depression, and anxiety. Brain connectivity analysis showed significant decreases in connectivity of the amygdala and insula with nodes of the posterior default mode network (pDMN; precuneus, posterior cingulate cortex, parietal lobules). Changes in connectivity were observed both in the resting state and during inhibition (Go/NoGo task). Moreover, the decrease of amygdala-pDMN connectivity was positively correlated with the reduction of depression and impulsivity after rTMS. Discussion: Despite the study limitations (open single-arm study in a small sample), our findings suggest that reduction of amygdala connectivity with pDMN network, which was positively associated with symptom reduction, is a candidate neural mechanism of rTMS effect in BPD. The observed effect might reflect the reduction of negative self-referential thinking in BPD patients after the rTMS treatment.

Návaznosti

MUNI/A/1664/2020, interní kód MU

Název: Behaviorální, neurozobrazovací a neurostimulační metody v psychiatrii (Akronym: NeuroPsych)

Investor: Masarykova univerzita, Behaviorální, neurozobrazovací a neurostimulační metody v psychiatrii

NU20-04-00410, projekt VaV

Název: Neurální mechanismy dialektické behaviorální terapie u pacientů s hraniční poruchou osobnosti (Akronym: NU20-04-00410)

Investor: Ministerstvo zdravotnictví ČR, Neurální mechanismy dialektické behaviorální terapie u pacientů s hraniční poruchou osobnosti, Podprogram 1 - standardní

Citovat

LINHARTOVÁ, Pavla, Tomáš SVĚRÁK, Martin GAJDOŠ a Tomáš KAŠPÁREK. Repetitive transcranial magnetic stimulation in borderline personality disorder: clinical and brain connectivity changes. In 4th International Brain Stimulation Meeting, December 6-9, 2021, Charleston, SC USA. 2021. Dostupné z: https://dx.doi.org/10.1016/j.brs.2021.10.292.

@proceedings{1824097,
   author = {Linhartová, Pavla and Svěrák, Tomáš and Gajdoš, Martin and Kašpárek, Tomáš},
   booktitle = {4th International Brain Stimulation Meeting, December 6-9, 2021, Charleston, SC USA},
   doi = {http://dx.doi.org/10.1016/j.brs.2021.10.292},
   keywords = {rTMS; borderline personality disorder; impulsivity; brain connectivity},
   language = {eng},
   title = {Repetitive transcranial magnetic stimulation in borderline personality disorder: clinical and brain connectivity changes},
   url = {https://www.brainstimjrnl.com/article/S1935-861X(21)00538-6/fulltext},
   year = {2021}
}

TY  - CONF
ID  - 1824097
AU  - Linhartová, Pavla - Svěrák, Tomáš - Gajdoš, Martin - Kašpárek, Tomáš
PY  - 2021
TI  - Repetitive transcranial magnetic stimulation in borderline personality disorder: clinical and brain connectivity changes
KW  - rTMS
KW  - borderline personality disorder
KW  - impulsivity
KW  - brain connectivity
UR  - https://www.brainstimjrnl.com/article/S1935-861X(21)00538-6/fulltext
N2  - Introduction: Repetitive transcranial magnetic stimulation (rTMS) is an innovative method in the treatment of BPD. Only several studies so far explored the effect of rTMS on BPD symptoms. We hypothesized that prefrontal rTMS in patients with BPD leads to improvement of symptoms with specific brain connectivity changes. Method: Fourteen patients with BPD received 15 sessions of individually navigated prefrontal rTMS over the right dorsolateral prefrontal cortex. Clinical effect was measured by Borderline Symptom List 23 (BSL-23), UPPS-P impulsive behavior scale, Difficulties in emotion regulation scale (DERS), Zung self-reported anxiety scale (SAS), and Montgomery and Åsberg Depression Rating Scale (MADRS). Brain connectivity changes after rTMS were assessed with seed connectivity analysis at resting-state fMRI and with beta series connectivity analysis during an fMRI Go/No Go task. Results: Comparison after vs. before rTMS showed a significant decrease in impulsivity, emotion dysregulation, depression, and anxiety. Brain connectivity analysis showed significant decreases in connectivity of the amygdala and insula with nodes of the posterior default mode network (pDMN; precuneus, posterior cingulate cortex, parietal lobules). Changes in connectivity were observed both in the resting state and during inhibition (Go/NoGo task). Moreover, the decrease of amygdala-pDMN connectivity was positively correlated with the reduction of depression and impulsivity after rTMS. Discussion: Despite the study limitations (open single-arm study in a small sample), our findings suggest that reduction of amygdala connectivity with pDMN network, which was positively associated with symptom reduction, is a candidate neural mechanism of rTMS effect in BPD. The observed effect might reflect the reduction of negative self-referential thinking in BPD patients after the rTMS treatment.
ER  -

LINHARTOVÁ, Pavla, Tomáš SVĚRÁK, Martin GAJDOŠ a Tomáš KAŠPÁREK. Repetitive transcranial magnetic stimulation in borderline personality disorder: clinical and brain connectivity changes. In \textit{4th International Brain Stimulation Meeting, December 6-9, 2021, Charleston, SC USA}. 2021. Dostupné z: https://dx.doi.org/10.1016/j.brs.2021.10.292.

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