Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like
Alterations in the Neurodevelopmental MAM Model of
Schizophrenia

J 2022

Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia

ŠTARK, Tibor, Fabio Arturo IANNOTI, Serena DI MARTINO, Martina DI BARTOLOMEO, Jana RUDÁ et. al.

Základní údaje

Originální název

Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia

Název česky

Časná blokáda CB1 receptorů normalizuje schizofrenii-podobné alterace v neurovývojovém MAM modelu schizofrenie

Autoři

ŠTARK, Tibor (703 Slovensko, domácí), Fabio Arturo IANNOTI (380 Itálie), Serena DI MARTINO (380 Itálie), Martina DI BARTOLOMEO (380 Itálie), Jana RUDÁ (203 Česká republika, garant, domácí), Fabiana PISCITELLI (380 Itálie), Carsten T. WOTJAK (276 Německo), Claudio D’ADDARIO (380 Itálie), Filippo DRAGO (380 Itálie), Vincenzo DI MARZO (380 Itálie) a Vincenzo MICALE (380 Itálie)

Vydání

Biomolecules, Basel, Switzerland, MDPI AG, 2022, 2218-273X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.500

Kód RIV

RIV/00216224:14110/22:00125204

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/biom12010108

UT WoS

000758489500001

Klíčová slova anglicky

MAM model; schizophrenia; AM251; endocannabinoid system; 2-arachidonoylglycerol (2-AG); cannabinoid CB1 receptor

Štítky

14110516, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 1. 2023 07:47, Mgr. Tereza Miškechová

Anotace

V originále

In agreement with the neurodevelopmental hypothesis of schizophrenia, prenatal exposure of Sprague-Dawley rats to the antimitotic agent methylazoxymethanol acetate (MAM) at gestational day 17 produces long-lasting behavioral alterations such as social withdrawal and cognitive impairment in adulthood, mimicking a schizophrenia-like phenotype. These abnormalities were preceded at neonatal age both by the delayed appearance of neonatal reflexes, an index of impaired brain maturation, and by higher 2-arachidonoylglycerol (2-AG) brain levels. Schizophrenia-like deficits were reversed by early treatment [from postnatal day (PND) 2 to PND 8] with the CB1 antagonist/inverse agonist AM251 (0.5 mg/kg/day). By contrast, early CB1 blockade affected the behavioral performance of control rats which was paralleled by enhanced 2-AG content in the prefrontal cortex (PFC). These results suggest that prenatal MAM insult leads to premorbid anomalies at neonatal age via altered tone of the endocannabinoid system, which may be considered as an early marker preceding the development of schizophrenia-like alterations in adulthood.

Návaznosti

MUNI/A/1440/2021, interní kód MU

Název: Preklinický a klinický výzkum Farmakologického ústavu v oblasti farmakokinetiky, neurobiologie závislostí a personalizované farmakoterapie v onkologii (Akronym: Farm-Pre-Klin)

Investor: Masarykova univerzita, Preklinický a klinický výzkum Farmakologického ústavu v oblasti farmakokinetiky, neurobiologie závislostí a personalizované farmakoterapie v onkologii

3SGA5789, interní kód MU

Název: PRECIPITATION OF SCHIZOPHRENIA-LIKE PHENOTYPE BY PRENATAL INFLUENCES: ASSESSING THE ROLE OF THE ENDOCANNABINOID SYSTEM (Akronym: ncRNAPain)

Investor: Jihomoravský kraj, PRECIPITATION OF SCHIZOPHRENIA-LIKE PHENOTYPE BY PRENATAL INFLUENCES: ASSESSING THE ROLE OF THE ENDOCANNABINOID SYSTEM, Granty pro zahraniční vědce

Citovat

ŠTARK, Tibor, Fabio Arturo IANNOTI, Serena DI MARTINO, Martina DI BARTOLOMEO, Jana RUDÁ, Fabiana PISCITELLI, Carsten T. WOTJAK, Claudio D’ADDARIO, Filippo DRAGO, Vincenzo DI MARZO a Vincenzo MICALE. Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia. Biomolecules. Basel, Switzerland: MDPI AG, 2022, roč. 12, č. 1, s. 1-15. ISSN 2218-273X. Dostupné z: https://dx.doi.org/10.3390/biom12010108.

@article{1824340,
   author = {Štark, Tibor and Iannoti, Fabio Arturo and Di Martino, Serena and Di Bartolomeo, Martina and Rudá, Jana and Piscitelli, Fabiana and Wotjak, Carsten T. and D’Addario, Claudio and Drago, Filippo and Di Marzo, Vincenzo and Micale, Vincenzo},
   article_location = {Basel, Switzerland},
   article_number = {1},
   doi = {http://dx.doi.org/10.3390/biom12010108},
   keywords = {MAM model; schizophrenia; AM251; endocannabinoid system; 2-arachidonoylglycerol (2-AG); cannabinoid CB1 receptor},
   language = {eng},
   issn = {2218-273X},
   journal = {Biomolecules},
   title = {Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia},
   url = {https://www.mdpi.com/2218-273X/12/1/108},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 1824340
AU  - Štark, Tibor - Iannoti, Fabio Arturo - Di Martino, Serena - Di Bartolomeo, Martina - Rudá, Jana - Piscitelli, Fabiana - Wotjak, Carsten T. - D’Addario, Claudio - Drago, Filippo - Di Marzo, Vincenzo - Micale, Vincenzo
PY  - 2022
TI  - Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia
JF  - Biomolecules
VL  - 12
IS  - 1
SP  - 1-15
EP  - 1-15
PB  - MDPI AG
SN  - 2218273X
KW  - MAM model
KW  - schizophrenia
KW  - AM251
KW  - endocannabinoid system
KW  - 2-arachidonoylglycerol (2-AG)
KW  - cannabinoid CB1 receptor
UR  - https://www.mdpi.com/2218-273X/12/1/108
N2  - In agreement with the neurodevelopmental hypothesis of schizophrenia, prenatal exposure of Sprague-Dawley rats to the antimitotic agent methylazoxymethanol acetate (MAM) at gestational day 17 produces long-lasting behavioral alterations such as social withdrawal and cognitive impairment in adulthood, mimicking a schizophrenia-like phenotype. These abnormalities were preceded at neonatal age both by the delayed appearance of neonatal reflexes, an index of impaired brain maturation, and by higher 2-arachidonoylglycerol (2-AG) brain levels. Schizophrenia-like deficits were reversed by early treatment [from postnatal day (PND) 2 to PND 8] with the CB1 antagonist/inverse agonist AM251 (0.5 mg/kg/day). By contrast, early CB1 blockade affected the behavioral performance of control rats which was paralleled by enhanced 2-AG content in the prefrontal cortex (PFC). These results suggest that prenatal MAM insult leads to premorbid anomalies at neonatal age via altered tone of the endocannabinoid system, which may be considered as an early marker preceding the development of schizophrenia-like alterations in adulthood.
ER  -

ŠTARK, Tibor, Fabio Arturo IANNOTI, Serena DI MARTINO, Martina DI BARTOLOMEO, Jana RUDÁ, Fabiana PISCITELLI, Carsten T. WOTJAK, Claudio D’ADDARIO, Filippo DRAGO, Vincenzo DI MARZO a Vincenzo MICALE. Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia. \textit{Biomolecules}. Basel, Switzerland: MDPI AG, 2022, roč.~12, č.~1, s.~1-15. ISSN~2218-273X. Dostupné z: https://dx.doi.org/10.3390/biom12010108.

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