| ŠTARK, Tibor, Fabio Arturo IANNOTI, Serena DI MARTINO, Martina DI BARTOLOMEO, Jana RUDÁ, Fabiana PISCITELLI, Carsten T. WOTJAK, Claudio D’ADDARIO, Filippo DRAGO, Vincenzo DI MARZO a Vincenzo MICALE. Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia. Biomolecules. Basel, Switzerland: MDPI AG, 2022, roč. 12, č. 1, s. 1-15. ISSN 2218-273X. Dostupné z: https://dx.doi.org/10.3390/biom12010108. |
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@article{1824340,
author = {Štark, Tibor and Iannoti, Fabio Arturo and Di Martino, Serena and Di Bartolomeo, Martina and Rudá, Jana and Piscitelli, Fabiana and Wotjak, Carsten T. and D’Addario, Claudio and Drago, Filippo and Di Marzo, Vincenzo and Micale, Vincenzo},
article_location = {Basel, Switzerland},
article_number = {1},
doi = {http://dx.doi.org/10.3390/biom12010108},
keywords = {MAM model; schizophrenia; AM251; endocannabinoid system; 2-arachidonoylglycerol (2-AG); cannabinoid CB1 receptor},
language = {eng},
issn = {2218-273X},
journal = {Biomolecules},
title = {Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia},
url = {https://www.mdpi.com/2218-273X/12/1/108},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 1824340
AU - Štark, Tibor - Iannoti, Fabio Arturo - Di Martino, Serena - Di Bartolomeo, Martina - Rudá, Jana - Piscitelli, Fabiana - Wotjak, Carsten T. - D’Addario, Claudio - Drago, Filippo - Di Marzo, Vincenzo - Micale, Vincenzo
PY - 2022
TI - Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia
JF - Biomolecules
VL - 12
IS - 1
SP - 1-15
EP - 1-15
PB - MDPI AG
SN - 2218273X
KW - MAM model
KW - schizophrenia
KW - AM251
KW - endocannabinoid system
KW - 2-arachidonoylglycerol (2-AG)
KW - cannabinoid CB1 receptor
UR - https://www.mdpi.com/2218-273X/12/1/108
N2 - In agreement with the neurodevelopmental hypothesis of schizophrenia, prenatal exposure of Sprague-Dawley rats to the antimitotic agent methylazoxymethanol acetate (MAM) at gestational day 17 produces long-lasting behavioral alterations such as social withdrawal and cognitive impairment in adulthood, mimicking a schizophrenia-like phenotype. These abnormalities were preceded at neonatal age both by the delayed appearance of neonatal reflexes, an index of impaired brain maturation, and by higher 2-arachidonoylglycerol (2-AG) brain levels. Schizophrenia-like deficits were reversed by early treatment [from postnatal day (PND) 2 to PND 8] with the CB1 antagonist/inverse agonist AM251 (0.5 mg/kg/day). By contrast, early CB1 blockade affected the behavioral performance of control rats which was paralleled by enhanced 2-AG content in the prefrontal cortex (PFC). These results suggest that prenatal MAM insult leads to premorbid anomalies at neonatal age via altered tone of the endocannabinoid system, which may be considered as an early marker preceding the development of schizophrenia-like alterations in adulthood.
ER -
ŠTARK, Tibor, Fabio Arturo IANNOTI, Serena DI MARTINO, Martina DI BARTOLOMEO, Jana RUDÁ, Fabiana PISCITELLI, Carsten T. WOTJAK, Claudio D’ADDARIO, Filippo DRAGO, Vincenzo DI MARZO a Vincenzo MICALE. Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia. \textit{Biomolecules}. Basel, Switzerland: MDPI AG, 2022, roč.~12, č.~1, s.~1-15. ISSN~2218-273X. Dostupné z: https://dx.doi.org/10.3390/biom12010108.
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