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@article{1824593, author = {Manakhov, Anton M. and Sitnikova, Natalya A. and Tsygankova, Alphiya R. and Alekseev, Alexander Yu. and Adamenko, Lyubov S. and Permyakova, Elizaveta and Baidyshev, Victor S. and Popov, Zakhar I. and Blahová, Lucie and Eliáš, Marek and Zajíčková, Lenka and Solovieva, Anastasiya O.}, article_location = {Basel}, article_number = {12}, doi = {http://dx.doi.org/10.3390/membranes11120965}, keywords = {PCL nanofibers; XPS; copper; antibacterial coating; ion release; cytotoxicity}, language = {eng}, issn = {2077-0375}, journal = {Membranes}, title = {Electrospun Biodegradable Nanofibers Coated Homogenously by Cu Magnetron Sputtering Exhibit Fast Ion Release. Computational and Experimental Study}, url = {https://www.mdpi.com/2077-0375/11/12/965}, volume = {11}, year = {2021} }
TY - JOUR ID - 1824593 AU - Manakhov, Anton M. - Sitnikova, Natalya A. - Tsygankova, Alphiya R. - Alekseev, Alexander Yu. - Adamenko, Lyubov S. - Permyakova, Elizaveta - Baidyshev, Victor S. - Popov, Zakhar I. - Blahová, Lucie - Eliáš, Marek - Zajíčková, Lenka - Solovieva, Anastasiya O. PY - 2021 TI - Electrospun Biodegradable Nanofibers Coated Homogenously by Cu Magnetron Sputtering Exhibit Fast Ion Release. Computational and Experimental Study JF - Membranes VL - 11 IS - 12 SP - 965 EP - 965 PB - MDPI SN - 20770375 KW - PCL nanofibers KW - XPS KW - copper KW - antibacterial coating KW - ion release KW - cytotoxicity UR - https://www.mdpi.com/2077-0375/11/12/965 N2 - Copper-coated nanofibrous materials are desirable for catalysis, electrochemistry, sensing, and biomedical use. The preparation of copper or copper-coated nanofibers can be pretty challenging, requiring many chemical steps that we eliminated in our robust approach, where for the first time, Cu was deposited by magnetron sputtering onto temperature-sensitive polymer nanofibers. For the first time, the large-scale modeling of PCL films irradiation by molecular dynamics simulation was performed and allowed to predict the ions penetration depth and tune the deposition conditions. The Cu-coated polycaprolactone (PCL) nanofibers were thoroughly characterized and tested as antibacterial agents for various Gram-positive and Gram-negative bacteria. Fast release of Cu2+ ions (concentration up to 3.4 mu g/mL) led to significant suppression of E. coli and S. aureus colonies but was insufficient against S. typhimurium and Ps. aeruginosa. The effect of Cu layer oxidation upon contact with liquid media was investigated by X-ray photoelectron spectroscopy revealing that, after two hours, 55% of Cu atoms are in form of CuO or Cu(OH)(2). The Cu-coated nanofibers will be great candidates for wound dressings thanks to an interesting synergistic effect: on the one hand, the rapid release of copper ions kills bacteria, while on the other hand, it stimulates the regeneration with the activation of immune cells. Indeed, copper ions are necessary for the bacteriostatic action of cells of the immune system. The reactive CO2/C2H4 plasma polymers deposited onto PCL-Cu nanofibers can be applied to grafting of viable proteins, peptides, or drugs, and it further explores the versatility of developed nanofibers for biomedical applications use. ER -
MANAKHOV, Anton M., Natalya A. SITNIKOVA, Alphiya R. TSYGANKOVA, Alexander Yu. ALEKSEEV, Lyubov S. ADAMENKO, Elizaveta PERMYAKOVA, Victor S. BAIDYSHEV, Zakhar I. POPOV, Lucie BLAHOVÁ, Marek ELIÁŠ, Lenka ZAJÍČKOVÁ a Anastasiya O. SOLOVIEVA. Electrospun Biodegradable Nanofibers Coated Homogenously by Cu Magnetron Sputtering Exhibit Fast Ion Release. Computational and Experimental Study. \textit{Membranes}. Basel: MDPI, 2021, roč.~11, č.~12, s.~965-983. ISSN~2077-0375. Dostupné z: https://dx.doi.org/10.3390/membranes11120965.
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