Risk factors for depression and anxiety in painful and painless
diabetic polyneuropathy: A multicentre observational
cross-sectional study

J 2022

Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study

KEC, David, Aneta RAJDOVÁ, Jana RAPUTOVÁ, Blanka ADAMOVÁ, Iva ŠROTOVÁ et. al.

Základní údaje

Originální název

Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study

Autoři

KEC, David (203 Česká republika, domácí), Aneta RAJDOVÁ (203 Česká republika, domácí), Jana RAPUTOVÁ (203 Česká republika, domácí), Blanka ADAMOVÁ (203 Česká republika, domácí), Iva ŠROTOVÁ (203 Česká republika, domácí), Eva KRÁLÍČKOVÁ NEKVAPILOVÁ (203 Česká republika, domácí), Radka NEUŽILOVÁ MICHALČÁKOVÁ (203 Česká republika), Magda HORÁKOVÁ (203 Česká republika, domácí), Jana BELOBRADKOVA (203 Česká republika), Jindrich OLSOVSKY (203 Česká republika), Pavel WEBER (203 Česká republika), Gabriel HAJAS (703 Slovensko), Michaela KAISEROVA (203 Česká republika), Radim MAZANEC (203 Česká republika), Veronika POTOCKOVA (203 Česká republika), Edvard EHLER (203 Česká republika), Martin FORGAC (203 Česká republika), Frank BIRKLEIN, Nurcan UCEYLER, Claudia SOMMER, Josef BEDNAŘÍK (203 Česká republika, domácí) a Eva VLČKOVÁ (203 Česká republika, garant, domácí)

Vydání

European Journal of Pain, Hoboken, Wiley, 2022, 1090-3801

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.600

Kód RIV

RIV/00216224:14110/22:00125211

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/ejp.1865

UT WoS

000705522100001

Klíčová slova anglicky

depression; anxiety; diabetic polyneuropathy; risk factors

Štítky

14110221, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 1. 2024 09:38, Mgr. Blanka Farkašová

Anotace

V originále

Background Despite the high prevalence of depression and anxiety in chronic pain conditions, current knowledge concerning emotional distress among painful diabetic polyneuropathy (pDSPN) and other diabetes mellitus (DM) sufferers is limited. Methods This observational multicentre cohort study employed the Hospital Anxiety and Depression Scale, the Beck Depression Inventory II and the State-Trait Anxiety Inventory to assess symptoms of depression and anxiety in several groups with diabetes, as well as in a control group. The study cohort included 347 pDSPN patients aged 63.4 years (median), 55.9% males; 311 pain-free diabetic polyneuropathy (nDSPN) patients aged 63.7 years, 57.9% males; 50 diabetes mellitus (DM) patients without polyneuropathy aged 61.5 years, 44.0% males; and 71 healthy controls (HC) aged 63.0 years, 42.3% males. The roles played in emotional distress were explored in terms of the biological, the clinical (diabetes-, neuropathy- and pain-related), the socio-economic and the cognitive factors (catastrophizing). Results The study disclosed a significantly higher prevalence of the symptoms of depression and anxiety not only in pDSPN (46.7% and 60.7%, respectively), but also in patients with nDSPN (24.4% and 44.4%) and DM without polyneuropathy (22.0% and 30.0%) compared with HCs (7.0% and 14.1%, p < 0.001). Multiple regression analysis demonstrated the severity of pain and neuropathy, catastrophic thinking, type 2 DM, lower age and female sex as independent contributors to depression and anxiety. Conclusions In addition to the severity of neuropathic pain and its cognitive processing, the severity of diabetic polyneuropathy and demographic factors are key independent contributors to emotional distress in diabetic individuals. Significance In large cohorts of well-defined painless and painful diabetic polyneuropathy patients and diabetic subjects without polyneuropathy, we found a high prevalence of the symptoms of depression and anxiety, mainly in painful individuals. We have confirmed neuropathic pain, its severity and cognitive processing (pain catastrophizing) as dominant risk factors for depression and anxiety. Furthermore, some demographic factors (lower age, female sex), type 2 diabetes mellitus and severity of diabetic polyneuropathy were newly identified as important contributors to emotional distress independent of pain.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

MUNI/A/1144/2021, interní kód MU

Název: Diagnostika a patofyziologie neuropatické bolesti a dalších symptomů a komorbidit neurologických onemocnění

Investor: Masarykova univerzita, Diagnostika a patofyziologie neuropatické bolesti a dalších symptomů a komorbidit neurologických onemocnění

MUNI/A/1600/2020, interní kód MU

Název: Diagnostika a patofyziologie neuropatické bolesti (Akronym: PNB)

Investor: Masarykova univerzita, Diagnostika a patofyziologie neuropatické bolesti

602133, interní kód MU

Název: ncRNAPain - Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine (Akronym: ncRNAPain)

Investor: Evropská unie, ncRNAPain - Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine, Spolupráce

Citovat

KEC, David, Aneta RAJDOVÁ, Jana RAPUTOVÁ, Blanka ADAMOVÁ, Iva ŠROTOVÁ, Eva KRÁLÍČKOVÁ NEKVAPILOVÁ, Radka NEUŽILOVÁ MICHALČÁKOVÁ, Magda HORÁKOVÁ, Jana BELOBRADKOVA, Jindrich OLSOVSKY, Pavel WEBER, Gabriel HAJAS, Michaela KAISEROVA, Radim MAZANEC, Veronika POTOCKOVA, Edvard EHLER, Martin FORGAC, Frank BIRKLEIN, Nurcan UCEYLER, Claudia SOMMER, Josef BEDNAŘÍK a Eva VLČKOVÁ. Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study. European Journal of Pain. Hoboken: Wiley, 2022, roč. 26, č. 2, s. 370-389. ISSN 1090-3801. Dostupné z: https://dx.doi.org/10.1002/ejp.1865.

@article{1824610,
   author = {Kec, David and Rajdová, Aneta and Raputová, Jana and Adamová, Blanka and Šrotová, Iva and Králíčková Nekvapilová, Eva and Neužilová Michalčáková, Radka and Horáková, Magda and Belobradkova, Jana and Olsovsky, Jindrich and Weber, Pavel and Hajas, Gabriel and Kaiserova, Michaela and Mazanec, Radim and Potockova, Veronika and Ehler, Edvard and Forgac, Martin and Birklein, Frank and Uceyler, Nurcan and Sommer, Claudia and Bednařík, Josef and Vlčková, Eva},
   article_location = {Hoboken},
   article_number = {2},
   doi = {http://dx.doi.org/10.1002/ejp.1865},
   keywords = {depression; anxiety; diabetic polyneuropathy; risk factors},
   language = {eng},
   issn = {1090-3801},
   journal = {European Journal of Pain},
   title = {Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study},
   url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.1865},
   volume = {26},
   year = {2022}
}

TY  - JOUR
ID  - 1824610
AU  - Kec, David - Rajdová, Aneta - Raputová, Jana - Adamová, Blanka - Šrotová, Iva - Králíčková Nekvapilová, Eva - Neužilová Michalčáková, Radka - Horáková, Magda - Belobradkova, Jana - Olsovsky, Jindrich - Weber, Pavel - Hajas, Gabriel - Kaiserova, Michaela - Mazanec, Radim - Potockova, Veronika - Ehler, Edvard - Forgac, Martin - Birklein, Frank - Uceyler, Nurcan - Sommer, Claudia - Bednařík, Josef - Vlčková, Eva
PY  - 2022
TI  - Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study
JF  - European Journal of Pain
VL  - 26
IS  - 2
SP  - 370-389
EP  - 370-389
PB  - Wiley
SN  - 10903801
KW  - depression
KW  - anxiety
KW  - diabetic polyneuropathy
KW  - risk factors
UR  - https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.1865
N2  - Background Despite the high prevalence of depression and anxiety in chronic pain conditions, current knowledge concerning emotional distress among painful diabetic polyneuropathy (pDSPN) and other diabetes mellitus (DM) sufferers is limited. Methods This observational multicentre cohort study employed the Hospital Anxiety and Depression Scale, the Beck Depression Inventory II and the State-Trait Anxiety Inventory to assess symptoms of depression and anxiety in several groups with diabetes, as well as in a control group. The study cohort included 347 pDSPN patients aged 63.4 years (median), 55.9% males; 311 pain-free diabetic polyneuropathy (nDSPN) patients aged 63.7 years, 57.9% males; 50 diabetes mellitus (DM) patients without polyneuropathy aged 61.5 years, 44.0% males; and 71 healthy controls (HC) aged 63.0 years, 42.3% males. The roles played in emotional distress were explored in terms of the biological, the clinical (diabetes-, neuropathy- and pain-related), the socio-economic and the cognitive factors (catastrophizing). Results The study disclosed a significantly higher prevalence of the symptoms of depression and anxiety not only in pDSPN (46.7% and 60.7%, respectively), but also in patients with nDSPN (24.4% and 44.4%) and DM without polyneuropathy (22.0% and 30.0%) compared with HCs (7.0% and 14.1%, p < 0.001). Multiple regression analysis demonstrated the severity of pain and neuropathy, catastrophic thinking, type 2 DM, lower age and female sex as independent contributors to depression and anxiety. Conclusions In addition to the severity of neuropathic pain and its cognitive processing, the severity of diabetic polyneuropathy and demographic factors are key independent contributors to emotional distress in diabetic individuals. Significance In large cohorts of well-defined painless and painful diabetic polyneuropathy patients and diabetic subjects without polyneuropathy, we found a high prevalence of the symptoms of depression and anxiety, mainly in painful individuals. We have confirmed neuropathic pain, its severity and cognitive processing (pain catastrophizing) as dominant risk factors for depression and anxiety. Furthermore, some demographic factors (lower age, female sex), type 2 diabetes mellitus and severity of diabetic polyneuropathy were newly identified as important contributors to emotional distress independent of pain.
ER  -

KEC, David, Aneta RAJDOVÁ, Jana RAPUTOVÁ, Blanka ADAMOVÁ, Iva ŠROTOVÁ, Eva KRÁLÍČKOVÁ NEKVAPILOVÁ, Radka NEUŽILOVÁ MICHALČÁKOVÁ, Magda HORÁKOVÁ, Jana BELOBRADKOVA, Jindrich OLSOVSKY, Pavel WEBER, Gabriel HAJAS, Michaela KAISEROVA, Radim MAZANEC, Veronika POTOCKOVA, Edvard EHLER, Martin FORGAC, Frank BIRKLEIN, Nurcan UCEYLER, Claudia SOMMER, Josef BEDNAŘÍK a Eva VLČKOVÁ. Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study. \textit{European Journal of Pain}. Hoboken: Wiley, 2022, roč.~26, č.~2, s.~370-389. ISSN~1090-3801. Dostupné z: https://dx.doi.org/10.1002/ejp.1865.

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