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@article{1824718,
author = {Abad, Etna and Samino, Sara and Grodzicki, Robert L. and Pagano, Giovanni and Trifuoggi, Marco and Graifer, Dmitry and Potěšil, David and Zdráhal, Zbyněk and Yanes, Oscar and Lyakhovich, Alex},
article_number = {APR},
doi = {http://dx.doi.org/10.1016/j.canlet.2020.12.010},
keywords = {Fanconi anemia; Cancer predisposition; de novo purine biosynthesis; Fumarate; Purinosome; Metabolic reprogramming},
language = {eng},
issn = {0304-3835},
journal = {Cancer Letters},
title = {Identification of metabolic changes leading to cancer susceptibility in Fanconi anemia cells},
url = {https://www.sciencedirect.com/science/article/pii/S0304383520306625?via%3Dihub},
volume = {503},
year = {2021}
}
TY - JOUR
ID - 1824718
AU - Abad, Etna - Samino, Sara - Grodzicki, Robert L. - Pagano, Giovanni - Trifuoggi, Marco - Graifer, Dmitry - Potěšil, David - Zdráhal, Zbyněk - Yanes, Oscar - Lyakhovich, Alex
PY - 2021
TI - Identification of metabolic changes leading to cancer susceptibility in Fanconi anemia cells
JF - Cancer Letters
VL - 503
IS - APR
SP - 185-196
EP - 185-196
PB - Elsevier
SN - 03043835
KW - Fanconi anemia
KW - Cancer predisposition
KW - de novo purine biosynthesis
KW - Fumarate
KW - Purinosome
KW - Metabolic reprogramming
UR - https://www.sciencedirect.com/science/article/pii/S0304383520306625?via%3Dihub
N2 - Fanconi anemia (FA) is a chromosomal instability disorder of bone marrow associated with aplastic anemia, congenital abnormalities and a high risk of malignancies. The identification of more than two dozen FA genes has revealed a plethora of interacting proteins that are mainly involved in repair of DNA interstrand crosslinks (ICLs). Other important findings associated with FA are inflammation, oxidative stress response, mitochondrial dysfunction and mitophagy. In this work, we performed quantitative proteomic and metabolomic analyses on defective FA cells and identified a number of metabolic abnormalities associated with cancer. In particular, an increased de novo purine biosynthesis, a high concentration of fumarate, and an accumulation of purinosomal clusters were found. This was in parallel with decreased OXPHOS and altered glycolysis. On the whole, our results indicate an association between the need for nitrogenous bases upon impaired DDR in FA cells with a subsequent increase in purine metabolism and a potential role in oncogenesis.
ER -
ABAD, Etna, Sara SAMINO, Robert L. GRODZICKI, Giovanni PAGANO, Marco TRIFUOGGI, Dmitry GRAIFER, David POTĚŠIL, Zbyněk ZDRÁHAL, Oscar YANES a Alex LYAKHOVICH. Identification of metabolic changes leading to cancer susceptibility in Fanconi anemia cells. \textit{Cancer Letters}. Elsevier, 2021, roč.~503, APR, s.~185-196. ISSN~0304-3835. Dostupné z: https://dx.doi.org/10.1016/j.canlet.2020.12.010.
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