Identification of metabolic changes leading to cancer
susceptibility in Fanconi anemia cells

J 2021

Identification of metabolic changes leading to cancer susceptibility in Fanconi anemia cells

ABAD, Etna, Sara SAMINO, Robert L. GRODZICKI, Giovanni PAGANO, Marco TRIFUOGGI et. al.

Základní údaje

Originální název

Identification of metabolic changes leading to cancer susceptibility in Fanconi anemia cells

Autoři

ABAD, Etna (724 Španělsko), Sara SAMINO (724 Španělsko), Robert L. GRODZICKI (840 Spojené státy), Giovanni PAGANO (380 Itálie), Marco TRIFUOGGI (380 Itálie), Dmitry GRAIFER (643 Rusko), David POTĚŠIL (203 Česká republika, domácí), Zbyněk ZDRÁHAL (203 Česká republika, garant, domácí), Oscar YANES (724 Španělsko) a Alex LYAKHOVICH (643 Rusko)

Vydání

Cancer Letters, Elsevier, 2021, 0304-3835

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

fulltext

Impakt faktor

Impact factor: 9.756

Kód RIV

RIV/00216224:14740/21:00119598

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.canlet.2020.12.010

UT WoS

000629990700018

Klíčová slova anglicky

Fanconi anemia; Cancer predisposition; de novo purine biosynthesis; Fumarate; Purinosome; Metabolic reprogramming

Štítky

CF PROT, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 11. 2024 20:39, Ing. Martina Blahová

Anotace

V originále

Fanconi anemia (FA) is a chromosomal instability disorder of bone marrow associated with aplastic anemia, congenital abnormalities and a high risk of malignancies. The identification of more than two dozen FA genes has revealed a plethora of interacting proteins that are mainly involved in repair of DNA interstrand crosslinks (ICLs). Other important findings associated with FA are inflammation, oxidative stress response, mitochondrial dysfunction and mitophagy. In this work, we performed quantitative proteomic and metabolomic analyses on defective FA cells and identified a number of metabolic abnormalities associated with cancer. In particular, an increased de novo purine biosynthesis, a high concentration of fumarate, and an accumulation of purinosomal clusters were found. This was in parallel with decreased OXPHOS and altered glycolysis. On the whole, our results indicate an association between the need for nitrogenous bases upon impaired DDR in FA cells with a subsequent increase in purine metabolism and a potential role in oncogenesis.

Návaznosti

GBP206/12/G151, projekt VaV

Název: Centrum nových přístupů k bioanalýze a molekulární diagnostice

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

90043, velká výzkumná infrastruktura

Název: CIISB

Citovat

ABAD, Etna, Sara SAMINO, Robert L. GRODZICKI, Giovanni PAGANO, Marco TRIFUOGGI, Dmitry GRAIFER, David POTĚŠIL, Zbyněk ZDRÁHAL, Oscar YANES a Alex LYAKHOVICH. Identification of metabolic changes leading to cancer susceptibility in Fanconi anemia cells. Cancer Letters. Elsevier, 2021, roč. 503, APR, s. 185-196. ISSN 0304-3835. Dostupné z: https://dx.doi.org/10.1016/j.canlet.2020.12.010.

@article{1824718,
   author = {Abad, Etna and Samino, Sara and Grodzicki, Robert L. and Pagano, Giovanni and Trifuoggi, Marco and Graifer, Dmitry and Potěšil, David and Zdráhal, Zbyněk and Yanes, Oscar and Lyakhovich, Alex},
   article_number = {APR},
   doi = {http://dx.doi.org/10.1016/j.canlet.2020.12.010},
   keywords = {Fanconi anemia; Cancer predisposition; de novo purine biosynthesis; Fumarate; Purinosome; Metabolic reprogramming},
   language = {eng},
   issn = {0304-3835},
   journal = {Cancer Letters},
   title = {Identification of metabolic changes leading to cancer susceptibility in Fanconi anemia cells},
   url = {https://www.sciencedirect.com/science/article/pii/S0304383520306625?via%3Dihub},
   volume = {503},
   year = {2021}
}

TY  - JOUR
ID  - 1824718
AU  - Abad, Etna - Samino, Sara - Grodzicki, Robert L. - Pagano, Giovanni - Trifuoggi, Marco - Graifer, Dmitry - Potěšil, David - Zdráhal, Zbyněk - Yanes, Oscar - Lyakhovich, Alex
PY  - 2021
TI  - Identification of metabolic changes leading to cancer susceptibility in Fanconi anemia cells
JF  - Cancer Letters
VL  - 503
IS  - APR
SP  - 185-196
EP  - 185-196
PB  - Elsevier
SN  - 03043835
KW  - Fanconi anemia
KW  - Cancer predisposition
KW  - de novo purine biosynthesis
KW  - Fumarate
KW  - Purinosome
KW  - Metabolic reprogramming
UR  - https://www.sciencedirect.com/science/article/pii/S0304383520306625?via%3Dihub
N2  - Fanconi anemia (FA) is a chromosomal instability disorder of bone marrow associated with aplastic anemia, congenital abnormalities and a high risk of malignancies. The identification of more than two dozen FA genes has revealed a plethora of interacting proteins that are mainly involved in repair of DNA interstrand crosslinks (ICLs). Other important findings associated with FA are inflammation, oxidative stress response, mitochondrial dysfunction and mitophagy. In this work, we performed quantitative proteomic and metabolomic analyses on defective FA cells and identified a number of metabolic abnormalities associated with cancer. In particular, an increased de novo purine biosynthesis, a high concentration of fumarate, and an accumulation of purinosomal clusters were found. This was in parallel with decreased OXPHOS and altered glycolysis. On the whole, our results indicate an association between the need for nitrogenous bases upon impaired DDR in FA cells with a subsequent increase in purine metabolism and a potential role in oncogenesis.
ER  -

ABAD, Etna, Sara SAMINO, Robert L. GRODZICKI, Giovanni PAGANO, Marco TRIFUOGGI, Dmitry GRAIFER, David POTĚŠIL, Zbyněk ZDRÁHAL, Oscar YANES a Alex LYAKHOVICH. Identification of metabolic changes leading to cancer susceptibility in Fanconi anemia cells. \textit{Cancer Letters}. Elsevier, 2021, roč.~503, APR, s.~185-196. ISSN~0304-3835. Dostupné z: https://dx.doi.org/10.1016/j.canlet.2020.12.010.

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