| MUNSTER, L., Michaela FOJTŮ, M. MUCHOVA, F. LATECKA, S. KACEROVA, Z. CAPAKOVA, Tamara JURIŇÁKOVÁ, I. KURITKA, Michal MASAŘÍK and J. VICHA. Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier. Carbohydrate Polymers. Oxford: ELSEVIER SCI LTD, 2021, vol. 272, November 2021, p. 1-9. ISSN 0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2021.118461. |
Other formats:
BibTeX
LaTeX
RIS
@article{1826200,
author = {Munster, L. and Fojtů, Michaela and Muchova, M. and Latecka, F. and Kacerova, S. and Capakova, Z. and Juriňáková, Tamara and Kuritka, I. and Masařík, Michal and Vicha, J.},
article_location = {Oxford},
article_number = {November 2021},
doi = {http://dx.doi.org/10.1016/j.carbpol.2021.118461},
keywords = {Drug-delivery; Dextran; Periodate oxidation; Molecular weight; Cisplatin; Carrier},
language = {eng},
issn = {0144-8617},
journal = {Carbohydrate Polymers},
title = {Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier},
url = {https://reader.elsevier.com/reader/sd/pii/S0144861721008481?token=6B980116FFE89BE9644D630E5871F9E438C2A85EC19DD545C3ABE52B8108EA349F2BD805D3531CE612288A0775CE71A2&originRegion=eu-west-1&originCreation=20220124064804},
volume = {272},
year = {2021}
}
TY - JOUR
ID - 1826200
AU - Munster, L. - Fojtů, Michaela - Muchova, M. - Latecka, F. - Kacerova, S. - Capakova, Z. - Juriňáková, Tamara - Kuritka, I. - Masařík, Michal - Vicha, J.
PY - 2021
TI - Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier
JF - Carbohydrate Polymers
VL - 272
IS - November 2021
SP - 1-9
EP - 1-9
PB - ELSEVIER SCI LTD
SN - 01448617
KW - Drug-delivery
KW - Dextran
KW - Periodate oxidation
KW - Molecular weight
KW - Cisplatin
KW - Carrier
UR - https://reader.elsevier.com/reader/sd/pii/S0144861721008481?token=6B980116FFE89BE9644D630E5871F9E438C2A85EC19DD545C3ABE52B8108EA349F2BD805D3531CE612288A0775CE71A2&originRegion=eu-west-1&originCreation=20220124064804
N2 - The molecular weight (M-w) of dextran derivatives, such as regioselectively oxidized dicarboxydextran (DXA), is greatly influencing their faith in an organism, which could be possibly used to improve anticancer drug delivery. Here we present a modified method of sulfonation-induced chain scission allowing direct and accurate control over the M-w of DXA without increasing its polydispersity. Prepared DXA derivatives (M-w = 10-185 kDa) have been conjugated to cisplatin and the M-w of the carrier found to have a significant impact on cisplatin release rates, in vitro cytotoxicity, and migrastatic potential. Conjugates with the high-M-w DXA showed particularly increased anticancer efficacy. The best conjugate was four times more effective against malignant prostatic cell lines than free cisplatin and significantly inhibited the ovarian cancer cell migration. This was traced to the characteristics of spontaneously formed cisplatin-crosslinked DXA nanogels influenced by M-w of DXA and amount of loaded cisplatin.
ER -
MUNSTER, L., Michaela FOJTŮ, M. MUCHOVA, F. LATECKA, S. KACEROVA, Z. CAPAKOVA, Tamara JURIŇÁKOVÁ, I. KURITKA, Michal MASAŘÍK and J. VICHA. Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier. \textit{Carbohydrate Polymers}. Oxford: ELSEVIER SCI LTD, 2021, vol.~272, November 2021, p.~1-9. ISSN~0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2021.118461.
|
