BÍLIK, Tomáš, Ivan STUPÁK, Jakub VYSLOUŽIL, Martin ČULEN and Jiří DOHNAL. Prehľad biorelevantných dynamických disolučných prístrojov (An Overview of Biorelevant Dynamic Dissolution Instruments). CHEMICKÉ LISTY. Praha: Česká společnost chemická, 2021, vol. 115, No 11, p. 602-608. ISSN 0009-2770. |
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@article{1826393, author = {Bílik, Tomáš and Stupák, Ivan and Vysloužil, Jakub and Čulen, Martin and Dohnal, Jiří}, article_location = {Praha}, article_number = {11}, keywords = {solid oral dosage forms; biorelevant dissolution test; in vitro gastrointestinal system}, language = {sla}, issn = {0009-2770}, journal = {CHEMICKÉ LISTY}, title = {Prehľad biorelevantných dynamických disolučných prístrojov}, url = {http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3953/3862}, volume = {115}, year = {2021} }
TY - JOUR ID - 1826393 AU - Bílik, Tomáš - Stupák, Ivan - Vysloužil, Jakub - Čulen, Martin - Dohnal, Jiří PY - 2021 TI - Prehľad biorelevantných dynamických disolučných prístrojov JF - CHEMICKÉ LISTY VL - 115 IS - 11 SP - 602-608 EP - 602-608 PB - Česká společnost chemická SN - 00092770 KW - solid oral dosage forms KW - biorelevant dissolution test KW - in vitro gastrointestinal system UR - http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3953/3862 N2 - The use of solid oral dosage forms depends on the degree of bioavailability of the active pharmaceutical ingredient. The rate and extent of the drug released from the dosage form and subsequently dissolved in the gastrointestinal fluids greatly affects its fate in the human body. In vitro dissolution test may provide an in-depth understanding of a drug formulation's behaviour in vivo, as long as it sufficiently simulates relevant gastrointestinal conditions. Therefore, the development of in vitro gastrointestinal systems, which reflects advanced technology and knowledge about the human body, is receiving considerable attention. This article is focused on the biorelevant dynamic apparatuses and their sophisticated design, overcoming many limitations of conventional dissolution devices and allowing a better correlation with in vivo behaviour of solid oral dosage forms. ER -
BÍLIK, Tomáš, Ivan STUPÁK, Jakub VYSLOUŽIL, Martin ČULEN and Jiří DOHNAL. Prehľad biorelevantných dynamických disolučných prístrojov (An Overview of Biorelevant Dynamic Dissolution Instruments). \textit{CHEMICKÉ LISTY}. Praha: Česká společnost chemická, 2021, vol.~115, No~11, p.~602-608. ISSN~0009-2770.
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