Pharyngeal Microbial Signatures Are Predictive of the Risk of
Fungal Pneumonia in Hematologic Patients

J 2021

Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients

COSTANTINI, Claudio, Emilia NUNZI, Angelica SPOLZINO, Melissa PALMIERI, Giorgia RENGA et. al.

Basic information

Original name

Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients

Authors

COSTANTINI, Claudio (380 Italy), Emilia NUNZI (380 Italy), Angelica SPOLZINO (380 Italy), Melissa PALMIERI (380 Italy), Giorgia RENGA (380 Italy), Teresa ZELANTE (380 Italy), Lukas ENGLMAIER (203 Czech Republic), Kateřina COUFALÍKOVÁ (203 Czech Republic, belonging to the institution), Zdeněk SPÁČIL (203 Czech Republic, guarantor, belonging to the institution), Monica BORGHI (380 Italy), Marina M. BELLET (380 Italy), Enzo ACERBI (702 Singapore), Matteo PUCCETTI (380 Italy), Stefano GIOVAGNOLI (380 Italy), Roberta SPACCAPELO (380 Italy), Vincenzo N. TALESA (380 Italy), Giuseppe LOMURNO (380 Italy), Francesco MERLI (380 Italy), Luca FACCHINI (380 Italy), Antonio SPADEA (380 Italy), Lorella MELILLO (380 Italy), Katia CODELUPPI (380 Italy), Francesco MARCHESI (380 Italy), Gessica MARCHESINI (380 Italy), Daniela VALENTE (380 Italy), Giulia DRAGONETTI (380 Italy), Gianpaolo NADALI (380 Italy), Livio PAGANO (380 Italy), Franco AVERSA (380 Italy) and Luigina ROMANI (380 Italy)

Edition

INFECTION AND IMMUNITY, WASHINGTON, The American Society for Microbiology, 2021, 0019-9567

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.609

RIV identification code

RIV/00216224:14310/21:00119613

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1128/IAI.00105-21

UT WoS

000707996800004

Keywords in English

hematological malignancies; airway microbiome; antibiotics; indole-3-aldehyde; invasive fungal infection; metabolomics; tryptophan

Abstract

V originále

The ability to predict invasive fungal infections (IFI) in patients with hematological malignancies is fundamental for successful therapy. Although gut dysbiosis is known to occur in hematological patients, whether airway dysbiosis also contributes to the risk of IFI has not been investigated. Nasal and oropharyngeal swabs were collected for functional microbiota characterization in 173 patients with hematological malignancies recruited in a multicenter, prospective, observational study and stratified according to the risk of developing IFI. A lower microbial richness and evenness were found in the pharyngeal microbiota of high-risk patients that were associated with a distinct taxonomic and metabolic profile. A murine model of IFI provided biologic plausibility for the finding that loss of protective anaerobes, such as Clostridiales and Bacteroidetes, along with an apparent restricted availability of tryptophan, is causally linked to the risk of IFI in hematologic patients and indicates avenues for antimicrobial stewardship and metabolic reequilibrium in IFI.

Links

EF15_003/0000469, research and development project

Name: Cetocoen Plus

EF17_043/0009632, research and development project

Name: CETOCOEN Excellence

GJ17-24592Y, research and development project

Name: Mapování interakcí mezi základními metabolickými pochody a střevní mikroflórou

Investor: Czech Science Foundation

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

857560, interní kód MU
(CEP code: EF17_043/0009632)

Name: CETOCOEN Excellence (Acronym: CETOCOEN Excellence)

Investor: European Union, Spreading excellence and widening participation

Citovat

COSTANTINI, Claudio, Emilia NUNZI, Angelica SPOLZINO, Melissa PALMIERI, Giorgia RENGA, Teresa ZELANTE, Lukas ENGLMAIER, Kateřina COUFALÍKOVÁ, Zdeněk SPÁČIL, Monica BORGHI, Marina M. BELLET, Enzo ACERBI, Matteo PUCCETTI, Stefano GIOVAGNOLI, Roberta SPACCAPELO, Vincenzo N. TALESA, Giuseppe LOMURNO, Francesco MERLI, Luca FACCHINI, Antonio SPADEA, Lorella MELILLO, Katia CODELUPPI, Francesco MARCHESI, Gessica MARCHESINI, Daniela VALENTE, Giulia DRAGONETTI, Gianpaolo NADALI, Livio PAGANO, Franco AVERSA and Luigina ROMANI. Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients. INFECTION AND IMMUNITY. WASHINGTON: The American Society for Microbiology, 2021, vol. 89, No 8, p. 1-17. ISSN 0019-9567. Available from: https://dx.doi.org/10.1128/IAI.00105-21.

@article{1826639,
   author = {Costantini, Claudio and Nunzi, Emilia and Spolzino, Angelica and Palmieri, Melissa and Renga, Giorgia and Zelante, Teresa and Englmaier, Lukas and Coufalíková, Kateřina and Spáčil, Zdeněk and Borghi, Monica and Bellet, Marina M. and Acerbi, Enzo and Puccetti, Matteo and Giovagnoli, Stefano and Spaccapelo, Roberta and Talesa, Vincenzo N. and Lomurno, Giuseppe and Merli, Francesco and Facchini, Luca and Spadea, Antonio and Melillo, Lorella and Codeluppi, Katia and Marchesi, Francesco and Marchesini, Gessica and Valente, Daniela and Dragonetti, Giulia and Nadali, Gianpaolo and Pagano, Livio and Aversa, Franco and Romani, Luigina},
   article_location = {WASHINGTON},
   article_number = {8},
   doi = {http://dx.doi.org/10.1128/IAI.00105-21},
   keywords = {hematological malignancies; airway microbiome; antibiotics; indole-3-aldehyde; invasive fungal infection; metabolomics; tryptophan},
   language = {eng},
   issn = {0019-9567},
   journal = {INFECTION AND IMMUNITY},
   title = {Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients},
   url = {https://journals.asm.org/doi/10.1128/IAI.00105-21},
   volume = {89},
   year = {2021}
}

TY  - JOUR
ID  - 1826639
AU  - Costantini, Claudio - Nunzi, Emilia - Spolzino, Angelica - Palmieri, Melissa - Renga, Giorgia - Zelante, Teresa - Englmaier, Lukas - Coufalíková, Kateřina - Spáčil, Zdeněk - Borghi, Monica - Bellet, Marina M. - Acerbi, Enzo - Puccetti, Matteo - Giovagnoli, Stefano - Spaccapelo, Roberta - Talesa, Vincenzo N. - Lomurno, Giuseppe - Merli, Francesco - Facchini, Luca - Spadea, Antonio - Melillo, Lorella - Codeluppi, Katia - Marchesi, Francesco - Marchesini, Gessica - Valente, Daniela - Dragonetti, Giulia - Nadali, Gianpaolo - Pagano, Livio - Aversa, Franco - Romani, Luigina
PY  - 2021
TI  - Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients
JF  - INFECTION AND IMMUNITY
VL  - 89
IS  - 8
SP  - 1-17
EP  - 1-17
PB  - The American Society for Microbiology
SN  - 00199567
KW  - hematological malignancies
KW  - airway microbiome
KW  - antibiotics
KW  - indole-3-aldehyde
KW  - invasive fungal infection
KW  - metabolomics
KW  - tryptophan
UR  - https://journals.asm.org/doi/10.1128/IAI.00105-21
N2  - The ability to predict invasive fungal infections (IFI) in patients with hematological malignancies is fundamental for successful therapy. Although gut dysbiosis is known to occur in hematological patients, whether airway dysbiosis also contributes to the risk of IFI has not been investigated. Nasal and oropharyngeal swabs were collected for functional microbiota characterization in 173 patients with hematological malignancies recruited in a multicenter, prospective, observational study and stratified according to the risk of developing IFI. A lower microbial richness and evenness were found in the pharyngeal microbiota of high-risk patients that were associated with a distinct taxonomic and metabolic profile. A murine model of IFI provided biologic plausibility for the finding that loss of protective anaerobes, such as Clostridiales and Bacteroidetes, along with an apparent restricted availability of tryptophan, is causally linked to the risk of IFI in hematologic patients and indicates avenues for antimicrobial stewardship and metabolic reequilibrium in IFI.
ER  -

COSTANTINI, Claudio, Emilia NUNZI, Angelica SPOLZINO, Melissa PALMIERI, Giorgia RENGA, Teresa ZELANTE, Lukas ENGLMAIER, Kateřina COUFALÍKOVÁ, Zdeněk SPÁČIL, Monica BORGHI, Marina M. BELLET, Enzo ACERBI, Matteo PUCCETTI, Stefano GIOVAGNOLI, Roberta SPACCAPELO, Vincenzo N. TALESA, Giuseppe LOMURNO, Francesco MERLI, Luca FACCHINI, Antonio SPADEA, Lorella MELILLO, Katia CODELUPPI, Francesco MARCHESI, Gessica MARCHESINI, Daniela VALENTE, Giulia DRAGONETTI, Gianpaolo NADALI, Livio PAGANO, Franco AVERSA and Luigina ROMANI. Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients. \textit{INFECTION AND IMMUNITY}. WASHINGTON: The American Society for Microbiology, 2021, vol.~89, No~8, p.~1-17. ISSN~0019-9567. Available from: https://dx.doi.org/10.1128/IAI.00105-21.

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