Efficacy of poly (lactic-co-glycolic acid) microparticles as a
gonadotropin-releasing hormone analogue delivery system to
stimulate ovulation of peled Coregonus peled

J 2021

Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation of peled Coregonus peled

KNOWLES, J., Jakub VYSLOUŽIL, Jan MUSELÍK, V. STEJSKAL, J. KOURIL et. al.

Basic information

Original name

Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation of peled Coregonus peled

Authors

KNOWLES, J. (guarantor), Jakub VYSLOUŽIL (203 Czech Republic, belonging to the institution), Jan MUSELÍK (203 Czech Republic, belonging to the institution), V. STEJSKAL, J. KOURIL and P. PODHOREC

Edition

Czech Journal of Animal Science, Prague, Czech Academy Agricultural Sciences, 2021, 1212-1819

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.349

RIV identification code

RIV/00216224:14160/21:00119766

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.17221/57/2021-CJAS

UT WoS

000680010100005

Keywords in English

induction of ovulation; GnRHa; salmonids; sustained drug release; steroid feedback

Abstract

V originále

The aim of the study was to determine the efficacy of poly (lactic-co-glycolic acid) microparticles as a carrier of gonadotropin-relea sing hormone analogues (GnRHa) for induction of ovulation in peled Coregonus peled. Female peled were injected intraperitoneally with 1) saline solution only (control), 2) mammalian GnRHa at 25 vg/kg body weight, 3) GnRHa in 753-type microparticles at 50 vg/kg, or 4) GnRHa in 653-type microparticles at 50 vg/kg. Blood plasma samples were taken on days 0, 4, 8, and 12 post-injection. All hormone treatments induced synchronous ovulation and higher cumulative ovulation compared to controls. Hormone treatments did not affect relative fecundity or the percentage of eyed eggs. Testosterone level decreased toward the onset of ovulation. On day eight of the trial, the testosterone level was significantly lower in hormone-treated groups compared to the control group. The level of 17P-oestradiol showed a decreasing trend post-injection, with the lowest observed level on day eight. Our results demonstrate that ovulation can be induced in the peled by the sustained - release of GnRHa in poly (lactic-co-glycolic acid) microparticles, but the treatment does not improve reproductive performance.

Links

QK1810221, research and development project

Name: Využití mikročástic jako nosičů hormonálně aktivních látek v řízené reprodukci ryb.

Investor: Ministry of Agriculture of the CR

Citovat

KNOWLES, J., Jakub VYSLOUŽIL, Jan MUSELÍK, V. STEJSKAL, J. KOURIL and P. PODHOREC. Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation of peled Coregonus peled. Czech Journal of Animal Science. Prague: Czech Academy Agricultural Sciences, 2021, vol. 66, No 8, p. 331-338. ISSN 1212-1819. Available from: https://dx.doi.org/10.17221/57/2021-CJAS.

@article{1826943,
   author = {Knowles, J. and Vysloužil, Jakub and Muselík, Jan and Stejskal, V. and Kouril, J. and Podhorec, P.},
   article_location = {Prague},
   article_number = {8},
   doi = {http://dx.doi.org/10.17221/57/2021-CJAS},
   keywords = {induction of ovulation; GnRHa; salmonids; sustained drug release; steroid feedback},
   language = {eng},
   issn = {1212-1819},
   journal = {Czech Journal of Animal Science},
   title = {Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation of peled Coregonus peled},
   url = {https://www.agriculturejournals.cz/web/cjas.htm?type=article&id=57_2021-CJAS},
   volume = {66},
   year = {2021}
}

TY  - JOUR
ID  - 1826943
AU  - Knowles, J. - Vysloužil, Jakub - Muselík, Jan - Stejskal, V. - Kouril, J. - Podhorec, P.
PY  - 2021
TI  - Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation of peled Coregonus peled
JF  - Czech Journal of Animal Science
VL  - 66
IS  - 8
SP  - 331-338
EP  - 331-338
PB  - Czech Academy Agricultural Sciences
SN  - 12121819
KW  - induction of ovulation
KW  - GnRHa
KW  - salmonids
KW  - sustained drug release
KW  - steroid feedback
UR  - https://www.agriculturejournals.cz/web/cjas.htm?type=article&id=57_2021-CJAS
N2  - The aim of the study was to determine the efficacy of poly (lactic-co-glycolic acid) microparticles as a carrier of gonadotropin-relea sing hormone analogues (GnRHa) for induction of ovulation in peled Coregonus peled. Female peled were injected intraperitoneally with 1) saline solution only (control), 2) mammalian GnRHa at 25 vg/kg body weight, 3) GnRHa in 753-type microparticles at 50 vg/kg, or 4) GnRHa in 653-type microparticles at 50 vg/kg. Blood plasma samples were taken on days 0, 4, 8, and 12 post-injection. All hormone treatments induced synchronous ovulation and higher cumulative ovulation compared to controls. Hormone treatments did not affect relative fecundity or the percentage of eyed eggs. Testosterone level decreased toward the onset of ovulation. On day eight of the trial, the testosterone level was significantly lower in hormone-treated groups compared to the control group. The level of 17P-oestradiol showed a decreasing trend post-injection, with the lowest observed level on day eight. Our results demonstrate that ovulation can be induced in the peled by the sustained - release of GnRHa in poly (lactic-co-glycolic acid) microparticles, but the treatment does not improve reproductive performance.
ER  -

KNOWLES, J., Jakub VYSLOUŽIL, Jan MUSELÍK, V. STEJSKAL, J. KOURIL and P. PODHOREC. Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation of peled Coregonus peled. \textit{Czech Journal of Animal Science}. Prague: Czech Academy Agricultural Sciences, 2021, vol.~66, No~8, p.~331-338. ISSN~1212-1819. Available from: https://dx.doi.org/10.17221/57/2021-CJAS.

Detailed Information on Publication Record