Evaluation and comparison of structurally different
cellulose-based hemostatic agents in a rat kidney model

J 2021

Evaluation and comparison of structurally different cellulose-based hemostatic agents in a rat kidney model

PAPRSKÁROVÁ, Alice, Pavel SUCHÝ, Marta CHALUPOVÁ, L. MICHLOVSKA, Jarmila KLUSÁKOVÁ et. al.

Základní údaje

Originální název

Evaluation and comparison of structurally different cellulose-based hemostatic agents in a rat kidney model

Autoři

PAPRSKÁROVÁ, Alice (203 Česká republika), Pavel SUCHÝ (203 Česká republika, garant, domácí), Marta CHALUPOVÁ (203 Česká republika, domácí), L. MICHLOVSKA, Jarmila KLUSÁKOVÁ (203 Česká republika, domácí), T. SOPUCH a L. VOJTOVA

Vydání

Cellulose, DORDRECHT, SPRINGER, 2021, 0969-0239

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.123

Kód RIV

RIV/00216224:14160/21:00119963

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.1007/s10570-021-04104-1

UT WoS

000682466900002

Klíčová slova anglicky

Hemostasis; Partial nephrectomy; Sponge; Nonwoven textile; Knitted fabric; Rat

Štítky

rivok, ÚFTo

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 4. 2022 12:47, JUDr. Sabina Krejčiříková

Anotace

V originále

Different topical hemostatic materials are used to achieve effective hemostasis. High hemostatic activity, biocompatibility, bioresorbability, and easy manipulation are to be expected in such a developed product. In the surgical world with these specific requirements, finding a proper hemostatic agent is very difficult. The study compared several materials of various construction properties, which were assessed for structural and related properties by morphological analyses and assessed in vivo for their efficiency and behaviour using a model of rat partial nephrectomy. New sodium salt of carboxymethyl cellulose (CMC) sponge with the lowest porosity and free swell absorptive capacity contained the highest amount of hydroxyl and carboxyl groups. Results revealed that this CMC material in the form of a bioresorbable sponge may ensure the necessary hemostatic effects, while also providing a positive influence on the reaction of the local tissue. The CMC material also needed significantly less time to achieve hemostasis (p < 0.001). Moreover, the sponge reached satisfactory results in the histopathological evaluation with the lowest destruction score and favorable healing reaction. This modified product proved itself to be a promising bioresorbable hemostat, which, according to its design, matches with its surgical applications. In general, the obtained data elucidated the dependency of the total effect on its structure and composition.

Návaznosti

TH04020540, projekt VaV

Název: Nová bioaktivní hemostatika a krytí ran na bázi kolagenu a celulózy

Investor: Technologická agentura ČR, Nová bioaktivní hemostatika a krytí ran na bázi kolagenu a celulózy

Citovat

PAPRSKÁROVÁ, Alice, Pavel SUCHÝ, Marta CHALUPOVÁ, L. MICHLOVSKA, Jarmila KLUSÁKOVÁ, T. SOPUCH a L. VOJTOVA. Evaluation and comparison of structurally different cellulose-based hemostatic agents in a rat kidney model. Cellulose. DORDRECHT: SPRINGER, 2021, roč. 28, č. 14, s. 9369-9382. ISSN 0969-0239. Dostupné z: https://dx.doi.org/10.1007/s10570-021-04104-1.

@article{1827346,
   author = {Paprskárová, Alice and Suchý, Pavel and Chalupová, Marta and Michlovska, L. and Klusáková, Jarmila and Sopuch, T. and Vojtova, L.},
   article_location = {DORDRECHT},
   article_number = {14},
   doi = {http://dx.doi.org/10.1007/s10570-021-04104-1},
   keywords = {Hemostasis; Partial nephrectomy; Sponge; Nonwoven textile; Knitted fabric; Rat},
   language = {eng},
   issn = {0969-0239},
   journal = {Cellulose},
   title = {Evaluation and comparison of structurally different cellulose-based hemostatic agents in a rat kidney model},
   url = {https://link.springer.com/article/10.1007%2Fs10570-021-04104-1},
   volume = {28},
   year = {2021}
}

TY  - JOUR
ID  - 1827346
AU  - Paprskárová, Alice - Suchý, Pavel - Chalupová, Marta - Michlovska, L. - Klusáková, Jarmila - Sopuch, T. - Vojtova, L.
PY  - 2021
TI  - Evaluation and comparison of structurally different cellulose-based hemostatic agents in a rat kidney model
JF  - Cellulose
VL  - 28
IS  - 14
SP  - 9369-9382
EP  - 9369-9382
PB  - SPRINGER
SN  - 09690239
KW  - Hemostasis
KW  - Partial nephrectomy
KW  - Sponge
KW  - Nonwoven textile
KW  - Knitted fabric
KW  - Rat
UR  - https://link.springer.com/article/10.1007%2Fs10570-021-04104-1
N2  - Different topical hemostatic materials are used to achieve effective hemostasis. High hemostatic activity, biocompatibility, bioresorbability, and easy manipulation are to be expected in such a developed product. In the surgical world with these specific requirements, finding a proper hemostatic agent is very difficult. The study compared several materials of various construction properties, which were assessed for structural and related properties by morphological analyses and assessed in vivo for their efficiency and behaviour using a model of rat partial nephrectomy. New sodium salt of carboxymethyl cellulose (CMC) sponge with the lowest porosity and free swell absorptive capacity contained the highest amount of hydroxyl and carboxyl groups. Results revealed that this CMC material in the form of a bioresorbable sponge may ensure the necessary hemostatic effects, while also providing a positive influence on the reaction of the local tissue. The CMC material also needed significantly less time to achieve hemostasis (p < 0.001). Moreover, the sponge reached satisfactory results in the histopathological evaluation with the lowest destruction score and favorable healing reaction. This modified product proved itself to be a promising bioresorbable hemostat, which, according to its design, matches with its surgical applications. In general, the obtained data elucidated the dependency of the total effect on its structure and composition.
ER  -

PAPRSKÁROVÁ, Alice, Pavel SUCHÝ, Marta CHALUPOVÁ, L. MICHLOVSKA, Jarmila KLUSÁKOVÁ, T. SOPUCH a L. VOJTOVA. Evaluation and comparison of structurally different cellulose-based hemostatic agents in a rat kidney model. \textit{Cellulose}. DORDRECHT: SPRINGER, 2021, roč.~28, č.~14, s.~9369-9382. ISSN~0969-0239. Dostupné z: https://dx.doi.org/10.1007/s10570-021-04104-1.

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