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@article{1827940,
author = {Pekarkova, Jana and Gablech, Imrich and Fialova, Tatiana and Bilek, Ondrej and Fohlerová, Zdenka},
article_location = {Laussane},
article_number = {December 2021},
doi = {http://dx.doi.org/10.3389/fbioe.2021.782799},
keywords = {parylene-C; micropillars; selenium nanoparticles; biocompatibility; antimicrobial},
language = {eng},
issn = {2296-4185},
journal = {Frontiers in bioengineering and biotechnology},
title = {Modifications of Parylene by Microstructures and Selenium Nanoparticles: Evaluation of Bacterial and Mesenchymal Stem Cell Viability},
url = {https://www.frontiersin.org/articles/10.3389/fbioe.2021.782799/full},
volume = {9},
year = {2021}
}
TY - JOUR
ID - 1827940
AU - Pekarkova, Jana - Gablech, Imrich - Fialova, Tatiana - Bilek, Ondrej - Fohlerová, Zdenka
PY - 2021
TI - Modifications of Parylene by Microstructures and Selenium Nanoparticles: Evaluation of Bacterial and Mesenchymal Stem Cell Viability
JF - Frontiers in bioengineering and biotechnology
VL - 9
IS - December 2021
SP - 1-11
EP - 1-11
PB - Frontiers Media S.A.
SN - 22964185
KW - parylene-C
KW - micropillars
KW - selenium nanoparticles
KW - biocompatibility
KW - antimicrobial
UR - https://www.frontiersin.org/articles/10.3389/fbioe.2021.782799/full
N2 - Parylene-based implants or coatings introduce surfaces suffering from bacteria colonization. Here, we synthesized polyvinylpyrrolidone-stabilized selenium nanoparticles (SeNPs) as the antibacterial agent, and various approaches are studied for their reproducible adsorption, and thus the modification of parylene-C-coated glass substrate. The nanoparticle deposition process is optimized in the nanoparticle concentration to obtain evenly distributed NPs on the flat parylene-C surface. Moreover, the array of parylene-C micropillars is fabricated by the plasma etching of parylene-C on a silicon wafer, and the surface is modified with SeNPs. All designed surfaces are tested against two bacterial pathogens, Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). The results show no antibacterial effect toward S. aureus, while some bacteriostatic effect is observed for E. coli on the flat and microstructured parylene. However, SeNPs did not enhance the antibacterial effect against both bacteria. Additionally, all designed surfaces show cytotoxic effects toward mesenchymal stem cells at high SeNP deposition. These results provide valuable information about the potential antibacterial treatment of widely used parylene-C in biomedicine.
ER -
PEKARKOVA, Jana, Imrich GABLECH, Tatiana FIALOVA, Ondrej BILEK a Zdenka FOHLEROVÁ. Modifications of Parylene by Microstructures and Selenium Nanoparticles: Evaluation of Bacterial and Mesenchymal Stem Cell Viability. \textit{Frontiers in bioengineering and biotechnology}. Laussane: Frontiers Media S.A., 2021, roč.~9, December 2021, s.~1-11. ISSN~2296-4185. Dostupné z: https://dx.doi.org/10.3389/fbioe.2021.782799.
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