Detailed Information on Publication Record
2021
Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients
PLESINGER, F., J. HALAMEK, Jan CHLÁDEK, P. JURAK, A. IVORA et. al.Basic information
Original name
Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients
Authors
PLESINGER, F. (203 Czech Republic), J. HALAMEK (203 Czech Republic), Jan CHLÁDEK (203 Czech Republic, belonging to the institution), P. JURAK (203 Czech Republic), A. IVORA (203 Czech Republic), Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution), Eva KORIŤÁKOVÁ (203 Czech Republic, belonging to the institution), Tereza JURKOVÁ (203 Czech Republic, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, belonging to the institution)
Edition
30 10 2021. Neuveden, 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, p. 5816-5819, 4 pp. 2021
Publisher
IEEE
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
30210 Clinical neurology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Publication form
electronic version available online
References:
RIV identification code
RIV/00216224:14110/21:00120218
Organization unit
Faculty of Medicine
ISSN
UT WoS
000760910505098
Keywords in English
Pre-implant Heart Activity; Vagal Nerve Stimulation Therapy; Epileptic Patients
Tags
Tags
International impact, Reviewed
Změněno: 31/5/2022 12:41, RNDr. Pavel Šmerk, Ph.D.
Abstract
V originále
Vagal Nerve Stimulation (VNS) is used to treat patients with pharmacoresistant epilepsy. However, generally accepted tools to predict VNS response do not exist. Here we examined two heart activity measures – mean RR and pNN50 and their complex behavior during activation in pre-implant measurements. The ECG recordings of 73 patients (38 responders, 36 non-responders) were examined in a 30-sec floating window before (120 sec), during (2x120 sec), and after (120 sec) the hyperventilation by nose and mouth. The VNS response differentiation by pNN50 was significant (min p=0.01) in the hyperventilation by a nose with a noticeable descendant trend in nominal values. The mean RR was significant (p=0.01) in the rest after the hyperventilation by mouth but after an approximately 40-sec delay.Clinical Relevance— Our study shows that pNN50 and mean RR can be used to distinguish between VNS responders and non-responders. However, details of dynamic behavior showed how this ability varies in tested measurement segments.
Links
| NV19-04-00343, research and development project |
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