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@inproceedings{1827944, author = {Plesinger, F. and Halamek, J. and Chládek, Jan and Jurak, P. and Ivora, A. and Doležalová, Irena and Koriťáková, Eva and Jurková, Tereza and Chrastina, Jan and Brázdil, Milan}, address = {Neuveden}, booktitle = {43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society}, doi = {http://dx.doi.org/10.1109/EMBC46164.2021.9629577}, edition = {30 10 2021}, keywords = {Pre-implant Heart Activity; Vagal Nerve Stimulation Therapy; Epileptic Patients}, howpublished = {elektronická verze "online"}, language = {eng}, location = {Neuveden}, pages = {5816-5819}, publisher = {IEEE}, title = {Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients}, url = {https://ieeexplore.ieee.org/document/9629577}, year = {2021} }
TY - JOUR ID - 1827944 AU - Plesinger, F. - Halamek, J. - Chládek, Jan - Jurak, P. - Ivora, A. - Doležalová, Irena - Koriťáková, Eva - Jurková, Tereza - Chrastina, Jan - Brázdil, Milan PY - 2021 TI - Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients PB - IEEE CY - Neuveden KW - Pre-implant Heart Activity KW - Vagal Nerve Stimulation Therapy KW - Epileptic Patients UR - https://ieeexplore.ieee.org/document/9629577 N2 - Vagal Nerve Stimulation (VNS) is used to treat patients with pharmacoresistant epilepsy. However, generally accepted tools to predict VNS response do not exist. Here we examined two heart activity measures – mean RR and pNN50 and their complex behavior during activation in pre-implant measurements. The ECG recordings of 73 patients (38 responders, 36 non-responders) were examined in a 30-sec floating window before (120 sec), during (2x120 sec), and after (120 sec) the hyperventilation by nose and mouth. The VNS response differentiation by pNN50 was significant (min p=0.01) in the hyperventilation by a nose with a noticeable descendant trend in nominal values. The mean RR was significant (p=0.01) in the rest after the hyperventilation by mouth but after an approximately 40-sec delay.Clinical Relevance— Our study shows that pNN50 and mean RR can be used to distinguish between VNS responders and non-responders. However, details of dynamic behavior showed how this ability varies in tested measurement segments. ER -
PLESINGER, F., J. HALAMEK, Jan CHLÁDEK, P. JURAK, A. IVORA, Irena DOLEŽALOVÁ, Eva KORIŤÁKOVÁ, Tereza JURKOVÁ, Jan CHRASTINA and Milan BRÁZDIL. Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients. Online. In \textit{43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society}. 30 10 2021. Neuveden: IEEE, 2021, p.~5816-5819. ISSN~2375-7477. Available from: https://dx.doi.org/10.1109/EMBC46164.2021.9629577.
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