Umbilical Cord Mesenchymal Stromal Cells for Cartilage
Regeneration Applications

J 2022

Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications

RUSSO, E., M. CAPRNDA, Peter KRUŽLIAK, P. G. CONALDI, C. V. BORLONGAN et. al.

Základní údaje

Originální název

Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications

Autoři

RUSSO, E., M. CAPRNDA, Peter KRUŽLIAK (703 Slovensko, domácí), P. G. CONALDI, C. V. BORLONGAN a G. LA ROCCA (garant)

Vydání

Stem Cells International, London, HINDAWI LTD, 2022, 1687-966X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.300

Kód RIV

RIV/00216224:14110/22:00125317

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1155/2022/2454168

UT WoS

000745969900002

Klíčová slova anglicky

Umbilical Cord Mesenchymal Stromal Cells; Cartilage Regeneration Applications

Štítky

14110121, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 1. 2022 10:37, Mgr. Tereza Miškechová

Anotace

V originále

Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies.

Citovat

RUSSO, E., M. CAPRNDA, Peter KRUŽLIAK, P. G. CONALDI, C. V. BORLONGAN a G. LA ROCCA. Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications. Stem Cells International. London: HINDAWI LTD, 2022, roč. 2022, January 2022, s. 1-23. ISSN 1687-966X. Dostupné z: https://dx.doi.org/10.1155/2022/2454168.

@article{1829389,
   author = {Russo, E. and Caprnda, M. and Kružliak, Peter and Conaldi, P. G. and Borlongan, C. V. and La Rocca, G.},
   article_location = {London},
   article_number = {January 2022},
   doi = {http://dx.doi.org/10.1155/2022/2454168},
   keywords = {Umbilical Cord Mesenchymal Stromal Cells; Cartilage Regeneration Applications},
   language = {eng},
   issn = {1687-966X},
   journal = {Stem Cells International},
   title = {Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications},
   url = {https://www.hindawi.com/journals/sci/2022/2454168/},
   volume = {2022},
   year = {2022}
}

TY  - JOUR
ID  - 1829389
AU  - Russo, E. - Caprnda, M. - Kružliak, Peter - Conaldi, P. G. - Borlongan, C. V. - La Rocca, G.
PY  - 2022
TI  - Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications
JF  - Stem Cells International
VL  - 2022
IS  - January 2022
SP  - 1-23
EP  - 1-23
PB  - HINDAWI LTD
SN  - 1687966X
KW  - Umbilical Cord Mesenchymal Stromal Cells
KW  - Cartilage Regeneration Applications
UR  - https://www.hindawi.com/journals/sci/2022/2454168/
N2  - Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies.
ER  -

RUSSO, E., M. CAPRNDA, Peter KRUŽLIAK, P. G. CONALDI, C. V. BORLONGAN a G. LA ROCCA. Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications. \textit{Stem Cells International}. London: HINDAWI LTD, 2022, roč.~2022, January 2022, s.~1-23. ISSN~1687-966X. Dostupné z: https://dx.doi.org/10.1155/2022/2454168.

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