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@article{1829389, author = {Russo, E. and Caprnda, M. and Kružliak, Peter and Conaldi, P. G. and Borlongan, C. V. and La Rocca, G.}, article_location = {London}, article_number = {January 2022}, doi = {http://dx.doi.org/10.1155/2022/2454168}, keywords = {Umbilical Cord Mesenchymal Stromal Cells; Cartilage Regeneration Applications}, language = {eng}, issn = {1687-966X}, journal = {Stem Cells International}, title = {Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications}, url = {https://www.hindawi.com/journals/sci/2022/2454168/}, volume = {2022}, year = {2022} }
TY - JOUR ID - 1829389 AU - Russo, E. - Caprnda, M. - Kružliak, Peter - Conaldi, P. G. - Borlongan, C. V. - La Rocca, G. PY - 2022 TI - Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications JF - Stem Cells International VL - 2022 IS - January 2022 SP - 1-23 EP - 1-23 PB - HINDAWI LTD SN - 1687966X KW - Umbilical Cord Mesenchymal Stromal Cells KW - Cartilage Regeneration Applications UR - https://www.hindawi.com/journals/sci/2022/2454168/ N2 - Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies. ER -
RUSSO, E., M. CAPRNDA, Peter KRUŽLIAK, P. G. CONALDI, C. V. BORLONGAN a G. LA ROCCA. Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications. \textit{Stem Cells International}. London: HINDAWI LTD, 2022, roč.~2022, January 2022, s.~1-23. ISSN~1687-966X. Dostupné z: https://dx.doi.org/10.1155/2022/2454168.
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