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@article{1829389,
author = {Russo, E. and Caprnda, M. and Kružliak, Peter and Conaldi, P. G. and Borlongan, C. V. and La Rocca, G.},
article_location = {London},
article_number = {January 2022},
doi = {http://dx.doi.org/10.1155/2022/2454168},
keywords = {Umbilical Cord Mesenchymal Stromal Cells; Cartilage Regeneration Applications},
language = {eng},
issn = {1687-966X},
journal = {Stem Cells International},
title = {Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications},
url = {https://www.hindawi.com/journals/sci/2022/2454168/},
volume = {2022},
year = {2022}
}
TY - JOUR
ID - 1829389
AU - Russo, E. - Caprnda, M. - Kružliak, Peter - Conaldi, P. G. - Borlongan, C. V. - La Rocca, G.
PY - 2022
TI - Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications
JF - Stem Cells International
VL - 2022
IS - January 2022
SP - 1-23
EP - 1-23
PB - HINDAWI LTD
SN - 1687966X
KW - Umbilical Cord Mesenchymal Stromal Cells
KW - Cartilage Regeneration Applications
UR - https://www.hindawi.com/journals/sci/2022/2454168/
N2 - Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies.
ER -
RUSSO, E., M. CAPRNDA, Peter KRUŽLIAK, P. G. CONALDI, C. V. BORLONGAN a G. LA ROCCA. Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications. \textit{Stem Cells International}. London: HINDAWI LTD, 2022, roč.~2022, January 2022, s.~1-23. ISSN~1687-966X. Dostupné z: https://dx.doi.org/10.1155/2022/2454168.
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