The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on
EMT-Related Proteins in Breast Cancer: Minireview

J 2021

The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview

BOBÁĽ, Pavel, M. LASTOVICKOVA a J. BOBALOVA

Základní údaje

Originální název

The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview

Autoři

BOBÁĽ, Pavel (703 Slovensko, domácí), M. LASTOVICKOVA a J. BOBALOVA (garant)

Vydání

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2021, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.208

Kód RIV

RIV/00216224:14160/21:00124008

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.3390/ijms222413345

UT WoS

000738236600001

Klíčová slova anglicky

breast cancer; EMT; protein; ATRA

Štítky

rivok, ÚChL

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 1. 2022 15:47, JUDr. Sabina Krejčiříková

Anotace

V originále

The knowledge of the structure, function, and abundance of specific proteins related to the EMT process is essential for developing effective diagnostic approaches to cancer with the perspective of diagnosis and therapy of malignancies. The success of all-trans retinoic acid (ATRA) differentiation therapy in acute promyelocytic leukemia has stimulated studies in the treatment of other tumors with ATRA. This review will discuss the impact of ATRA use, emphasizing epithelial-mesenchymal transition (EMT) proteins in breast cancer, of which metastasis and recurrence are major causes of death.

Návaznosti

MUNI/A/1682/2020, interní kód MU

Název: Návrh, syntéza a hodnocení derivátů skupin léčiv s inhibiční enzymatickou aktivitou

Investor: Masarykova univerzita, Návrh, syntéza a hodnocení derivátů skupin léčiv s inhibiční enzymatickou aktivitou

Citovat

BOBÁĽ, Pavel, M. LASTOVICKOVA a J. BOBALOVA. The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2021, roč. 22, č. 24, s. 1-18. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms222413345.

@article{1829630,
   author = {Bobáľ, Pavel and Lastovickova, M. and Bobalova, J.},
   article_location = {Basel},
   article_number = {24},
   doi = {http://dx.doi.org/10.3390/ijms222413345},
   keywords = {breast cancer; EMT; protein; ATRA},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview},
   url = {https://www.mdpi.com/1422-0067/22/24/13345/htm},
   volume = {22},
   year = {2021}
}

TY  - JOUR
ID  - 1829630
AU  - Bobáľ, Pavel - Lastovickova, M. - Bobalova, J.
PY  - 2021
TI  - The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview
JF  - International Journal of Molecular Sciences
VL  - 22
IS  - 24
SP  - 1-18
EP  - 1-18
PB  - Multidisciplinary Digital Publishing Institute
SN  - 14220067
KW  - breast cancer
KW  - EMT
KW  - protein
KW  - ATRA
UR  - https://www.mdpi.com/1422-0067/22/24/13345/htm
N2  - The knowledge of the structure, function, and abundance of specific proteins related to the EMT process is essential for developing effective diagnostic approaches to cancer with the perspective of diagnosis and therapy of malignancies. The success of all-trans retinoic acid (ATRA) differentiation therapy in acute promyelocytic leukemia has stimulated studies in the treatment of other tumors with ATRA. This review will discuss the impact of ATRA use, emphasizing epithelial-mesenchymal transition (EMT) proteins in breast cancer, of which metastasis and recurrence are major causes of death.
ER  -

BOBÁĽ, Pavel, M. LASTOVICKOVA a J. BOBALOVA. The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2021, roč.~22, č.~24, s.~1-18. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms222413345.

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