Další formáty:
BibTeX
LaTeX
RIS
@article{1830023,
author = {Pazourek, Jiří and Nytrová, Lucie and Odehnalová, Klára},
article_location = {WASHINGTON},
article_number = {1},
doi = {http://dx.doi.org/10.1021/acsomega.1c06224},
keywords = {HIGH-THROUGHPUT METHOD;DISSOCIATION-CONSTANTS;PK(A) DETERMINATION;MOBILITIESVALUES;DRUGS},
language = {eng},
issn = {2470-1343},
journal = {ACS Omega},
title = {Extension of the Internal Standard Method for Determination of Thermodynamic Acidity Constants of Compounds Sparingly Soluble in Water by Capillary Zone Electrophoresis},
url = {https://pubs.acs.org/doi/10.1021/acsomega.1c06224},
volume = {7},
year = {2021}
}
TY - JOUR
ID - 1830023
AU - Pazourek, Jiří - Nytrová, Lucie - Odehnalová, Klára
PY - 2021
TI - Extension of the Internal Standard Method for Determination of Thermodynamic Acidity Constants of Compounds Sparingly Soluble in Water by Capillary Zone Electrophoresis
JF - ACS Omega
VL - 7
IS - 1
SP - 1477-1482
EP - 1477-1482
PB - AMER CHEMICAL SOC
SN - 24701343
KW - HIGH-THROUGHPUT METHOD;DISSOCIATION-CONSTANTS;PK(A) DETERMINATION;MOBILITIESVALUES;DRUGS
UR - https://pubs.acs.org/doi/10.1021/acsomega.1c06224
N2 - The paper extends applicability of the internal standard method published in 2009 (Fuguet E. et al., J. Chromatogr. A 2009, 1216(17), 3646). Although the original capillary zone electrophoresis method was suggested to determine thermodynamic acidity constants of compounds sparingly soluble in aqueous solutions by carrying out only runs at two different pH values (i.e., without the need to perform many experiments over the appropriate pH range including the form of a low-ionized analyte), we proved that the approach also virtually overcomes any interactions of the analyte in mixed solvents, so that the experiments can be carried out in a methanol-water buffer where the solubility is much better. Applicability of the extended method is illustrated on six selected beta-blockers.
ER -
PAZOUREK, Jiří, Lucie NYTROVÁ a Klára ODEHNALOVÁ. Extension of the Internal Standard Method for Determination of Thermodynamic Acidity Constants of Compounds Sparingly Soluble in Water by Capillary Zone Electrophoresis. \textit{ACS Omega}. WASHINGTON: AMER CHEMICAL SOC, 2021, roč.~7, č.~1, s.~1477-1482. ISSN~2470-1343. Dostupné z: https://dx.doi.org/10.1021/acsomega.1c06224.
|
