Extension of the Internal Standard Method for Determination of
Thermodynamic Acidity Constants of Compounds Sparingly Soluble
in Water by Capillary Zone Electrophoresis

J 2021

Extension of the Internal Standard Method for Determination of Thermodynamic Acidity Constants of Compounds Sparingly Soluble in Water by Capillary Zone Electrophoresis

PAZOUREK, Jiří, Lucie NYTROVÁ a Klára ODEHNALOVÁ

Základní údaje

Originální název

Extension of the Internal Standard Method for Determination of Thermodynamic Acidity Constants of Compounds Sparingly Soluble in Water by Capillary Zone Electrophoresis

Autoři

PAZOUREK, Jiří (203 Česká republika, garant, domácí), Lucie NYTROVÁ (203 Česká republika, domácí) a Klára ODEHNALOVÁ (203 Česká republika, domácí)

Vydání

ACS Omega, WASHINGTON, AMER CHEMICAL SOC, 2021, 2470-1343

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10406 Analytical chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.132

Kód RIV

RIV/00216224:14160/21:00124011

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.1021/acsomega.1c06224

UT WoS

000739325200001

Klíčová slova anglicky

HIGH-THROUGHPUT METHOD;DISSOCIATION-CONSTANTS;PK(A) DETERMINATION;MOBILITIESVALUES;DRUGS

Štítky

rivok, ÚChL

Změněno: 14. 4. 2022 12:53, JUDr. Sabina Krejčiříková

Anotace

V originále

The paper extends applicability of the internal standard method published in 2009 (Fuguet E. et al., J. Chromatogr. A 2009, 1216(17), 3646). Although the original capillary zone electrophoresis method was suggested to determine thermodynamic acidity constants of compounds sparingly soluble in aqueous solutions by carrying out only runs at two different pH values (i.e., without the need to perform many experiments over the appropriate pH range including the form of a low-ionized analyte), we proved that the approach also virtually overcomes any interactions of the analyte in mixed solvents, so that the experiments can be carried out in a methanol-water buffer where the solubility is much better. Applicability of the extended method is illustrated on six selected beta-blockers.

Citovat

PAZOUREK, Jiří, Lucie NYTROVÁ a Klára ODEHNALOVÁ. Extension of the Internal Standard Method for Determination of Thermodynamic Acidity Constants of Compounds Sparingly Soluble in Water by Capillary Zone Electrophoresis. ACS Omega. WASHINGTON: AMER CHEMICAL SOC, 2021, roč. 7, č. 1, s. 1477-1482. ISSN 2470-1343. Dostupné z: https://dx.doi.org/10.1021/acsomega.1c06224.

@article{1830023,
   author = {Pazourek, Jiří and Nytrová, Lucie and Odehnalová, Klára},
   article_location = {WASHINGTON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1021/acsomega.1c06224},
   keywords = {HIGH-THROUGHPUT METHOD;DISSOCIATION-CONSTANTS;PK(A) DETERMINATION;MOBILITIESVALUES;DRUGS},
   language = {eng},
   issn = {2470-1343},
   journal = {ACS Omega},
   title = {Extension of the Internal Standard Method for Determination of Thermodynamic Acidity Constants of Compounds Sparingly Soluble in Water by Capillary Zone Electrophoresis},
   url = {https://pubs.acs.org/doi/10.1021/acsomega.1c06224},
   volume = {7},
   year = {2021}
}

TY  - JOUR
ID  - 1830023
AU  - Pazourek, Jiří - Nytrová, Lucie - Odehnalová, Klára
PY  - 2021
TI  - Extension of the Internal Standard Method for Determination of Thermodynamic Acidity Constants of Compounds Sparingly Soluble in Water by Capillary Zone Electrophoresis
JF  - ACS Omega
VL  - 7
IS  - 1
SP  - 1477-1482
EP  - 1477-1482
PB  - AMER CHEMICAL SOC
SN  - 24701343
KW  - HIGH-THROUGHPUT METHOD;DISSOCIATION-CONSTANTS;PK(A) DETERMINATION;MOBILITIESVALUES;DRUGS
UR  - https://pubs.acs.org/doi/10.1021/acsomega.1c06224
N2  - The paper extends applicability of the internal standard method published in 2009 (Fuguet E. et al., J. Chromatogr. A 2009, 1216(17), 3646). Although the original capillary zone electrophoresis method was suggested to determine thermodynamic acidity constants of compounds sparingly soluble in aqueous solutions by carrying out only runs at two different pH values (i.e., without the need to perform many experiments over the appropriate pH range including the form of a low-ionized analyte), we proved that the approach also virtually overcomes any interactions of the analyte in mixed solvents, so that the experiments can be carried out in a methanol-water buffer where the solubility is much better. Applicability of the extended method is illustrated on six selected beta-blockers.
ER  -

PAZOUREK, Jiří, Lucie NYTROVÁ a Klára ODEHNALOVÁ. Extension of the Internal Standard Method for Determination of Thermodynamic Acidity Constants of Compounds Sparingly Soluble in Water by Capillary Zone Electrophoresis. \textit{ACS Omega}. WASHINGTON: AMER CHEMICAL SOC, 2021, roč.~7, č.~1, s.~1477-1482. ISSN~2470-1343. Dostupné z: https://dx.doi.org/10.1021/acsomega.1c06224.

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