PIŽEM, Dominik, Ľubomíra NOVÁKOVÁ, Martin GAJDOŠ a Irena REKTOROVÁ. Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls. Journal of Neural Transmission. Springer, 2022, roč. 129, č. 3, s. 319-329. ISSN 0300-9564. Dostupné z: https://dx.doi.org/10.1007/s00702-022-02466-9. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1830201, author = {Pižem, Dominik and Nováková, Ľubomíra and Gajdoš, Martin and Rektorová, Irena}, article_number = {3}, doi = {http://dx.doi.org/10.1007/s00702-022-02466-9}, keywords = {Cognitive; Control condition; SimNIBS; Transcranial magnetic stimulation; Vertex stimulation; rTMS}, language = {eng}, issn = {0300-9564}, journal = {Journal of Neural Transmission}, title = {Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls}, url = {https://link.springer.com/content/pdf/10.1007/s00702-022-02466-9.pdf}, volume = {129}, year = {2022} }
TY - JOUR ID - 1830201 AU - Pižem, Dominik - Nováková, Ľubomíra - Gajdoš, Martin - Rektorová, Irena PY - 2022 TI - Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls JF - Journal of Neural Transmission VL - 129 IS - 3 SP - 319-329 EP - 319-329 PB - Springer SN - 03009564 KW - Cognitive KW - Control condition KW - SimNIBS KW - Transcranial magnetic stimulation KW - Vertex stimulation KW - rTMS UR - https://link.springer.com/content/pdf/10.1007/s00702-022-02466-9.pdf N2 - The vertex has been used as a suitable control stimulation site in repetitive transcranial magnetic stimulation studies. The objectives of this study are (1) to assess cognitive performance (CP) after theta burst stimulation (TBS); (2) to evaluate whether clinically relevant cortical areas might be reached by vertex stimulation and how that might influence CP. Twenty young healthy subjects performed a cognitive task prior to and immediately after intermittent TBS (iTBS) and continuous TBS (cTBS) of two active cortical stimulation sites and the vertex. We used the Wilcoxon signed-rank test to compare the pre- and post-stimulation reaction times (RTs) and a mixed ANOVA analysis to evaluate the effect of the stimulation on changes in RTs. A three-dimensional finite-element model (FEM) was used to calculate the vertex TBS-induced electrical field (E-field) in the adjacent regions of interest (ROIs). Correlation analyses were performed between E-fields in the ROIs and cognitive outcomes. We found a significant effect only of the stimulation time factor (F (1,12) = 65.37, p < 0.001) on RT shortening, with no superiority of the active site stimulation compared to the vertex stimulation. In 73.5% of vertex TBS sessions, a significant E-field was induced in at least one ROI. We found a negative association between the magnitude of the iTBS-induced E-fields and RT changes (R = - 0.54, p = 0.04). TBS protocols may lead to changes in CP when applied over the craniometrically targeted vertex. We therefore suggest not using a conventional approach as a vertex targeting method. ER -
PIŽEM, Dominik, Ľubomíra NOVÁKOVÁ, Martin GAJDOŠ a Irena REKTOROVÁ. Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls. \textit{Journal of Neural Transmission}. Springer, 2022, roč.~129, č.~3, s.~319-329. ISSN~0300-9564. Dostupné z: https://dx.doi.org/10.1007/s00702-022-02466-9.
|