Is the vertex a good control stimulation site? Theta burst
stimulation in healthy controls

J 2022

Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls

PIŽEM, Dominik, Ľubomíra NOVÁKOVÁ, Martin GAJDOŠ a Irena REKTOROVÁ

Základní údaje

Originální název

Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls

Autoři

PIŽEM, Dominik (703 Slovensko, domácí), Ľubomíra NOVÁKOVÁ (703 Slovensko, domácí), Martin GAJDOŠ (203 Česká republika, domácí) a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

Journal of Neural Transmission, Springer, 2022, 0300-9564

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.300

Kód RIV

RIV/00216224:14740/22:00125326

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1007/s00702-022-02466-9

UT WoS

000746752700001

Klíčová slova česky

Kognice, kontrolní podmínka, SimNIBS, Trankraniální magnetická stimulace, stimulace vertexu, rTMS

Klíčová slova anglicky

Cognitive; Control condition; SimNIBS; Transcranial magnetic stimulation; Vertex stimulation; rTMS

Štítky

14110127, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 10. 2024 10:25, Ing. Jana Kuchtová

Anotace

V originále

The vertex has been used as a suitable control stimulation site in repetitive transcranial magnetic stimulation studies. The objectives of this study are (1) to assess cognitive performance (CP) after theta burst stimulation (TBS); (2) to evaluate whether clinically relevant cortical areas might be reached by vertex stimulation and how that might influence CP. Twenty young healthy subjects performed a cognitive task prior to and immediately after intermittent TBS (iTBS) and continuous TBS (cTBS) of two active cortical stimulation sites and the vertex. We used the Wilcoxon signed-rank test to compare the pre- and post-stimulation reaction times (RTs) and a mixed ANOVA analysis to evaluate the effect of the stimulation on changes in RTs. A three-dimensional finite-element model (FEM) was used to calculate the vertex TBS-induced electrical field (E-field) in the adjacent regions of interest (ROIs). Correlation analyses were performed between E-fields in the ROIs and cognitive outcomes. We found a significant effect only of the stimulation time factor (F (1,12) = 65.37, p < 0.001) on RT shortening, with no superiority of the active site stimulation compared to the vertex stimulation. In 73.5% of vertex TBS sessions, a significant E-field was induced in at least one ROI. We found a negative association between the magnitude of the iTBS-induced E-fields and RT changes (R = - 0.54, p = 0.04). TBS protocols may lead to changes in CP when applied over the craniometrically targeted vertex. We therefore suggest not using a conventional approach as a vertex targeting method.

Návaznosti

GF21-13462L, projekt VaV

Název: Nové individualizované přístupy mozkové stimulace založené na synchronizaci v mozkových sítích pro zlepšení kognice zdravých seniorů a pacientů s MCI

Investor: Grantová agentura ČR, Nové individualizované přístupy mozkové stimulace založené na synchronizaci v mozkových sítích pro zlepšení kognice zdravých seniorů a pacientů s MCI, Partnerská agentura (Švýcarsko)

NV16-31868A, projekt VaV

Název: Ovlivnění kognitivních funkcí a konektivity mozku pomocí neinvazivní mozkové stimulace u pacientů s mírnou kognitivní poruchou u Alzheimerovy choroby

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

PIŽEM, Dominik, Ľubomíra NOVÁKOVÁ, Martin GAJDOŠ a Irena REKTOROVÁ. Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls. Journal of Neural Transmission. Springer, 2022, roč. 129, č. 3, s. 319-329. ISSN 0300-9564. Dostupné z: https://dx.doi.org/10.1007/s00702-022-02466-9.

@article{1830201,
   author = {Pižem, Dominik and Nováková, Ľubomíra and Gajdoš, Martin and Rektorová, Irena},
   article_number = {3},
   doi = {http://dx.doi.org/10.1007/s00702-022-02466-9},
   keywords = {Cognitive; Control condition; SimNIBS; Transcranial magnetic stimulation; Vertex stimulation; rTMS},
   language = {eng},
   issn = {0300-9564},
   journal = {Journal of Neural Transmission},
   title = {Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls},
   url = {https://link.springer.com/content/pdf/10.1007/s00702-022-02466-9.pdf},
   volume = {129},
   year = {2022}
}

TY  - JOUR
ID  - 1830201
AU  - Pižem, Dominik - Nováková, Ľubomíra - Gajdoš, Martin - Rektorová, Irena
PY  - 2022
TI  - Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls
JF  - Journal of Neural Transmission
VL  - 129
IS  - 3
SP  - 319-329
EP  - 319-329
PB  - Springer
SN  - 03009564
KW  - Cognitive
KW  - Control condition
KW  - SimNIBS
KW  - Transcranial magnetic stimulation
KW  - Vertex stimulation
KW  - rTMS
UR  - https://link.springer.com/content/pdf/10.1007/s00702-022-02466-9.pdf
N2  - The vertex has been used as a suitable control stimulation site in repetitive transcranial magnetic stimulation studies. The objectives of this study are (1) to assess cognitive performance (CP) after theta burst stimulation (TBS); (2) to evaluate whether clinically relevant cortical areas might be reached by vertex stimulation and how that might influence CP. Twenty young healthy subjects performed a cognitive task prior to and immediately after intermittent TBS (iTBS) and continuous TBS (cTBS) of two active cortical stimulation sites and the vertex. We used the Wilcoxon signed-rank test to compare the pre- and post-stimulation reaction times (RTs) and a mixed ANOVA analysis to evaluate the effect of the stimulation on changes in RTs. A three-dimensional finite-element model (FEM) was used to calculate the vertex TBS-induced electrical field (E-field) in the adjacent regions of interest (ROIs). Correlation analyses were performed between E-fields in the ROIs and cognitive outcomes. We found a significant effect only of the stimulation time factor (F (1,12) = 65.37, p < 0.001) on RT shortening, with no superiority of the active site stimulation compared to the vertex stimulation. In 73.5% of vertex TBS sessions, a significant E-field was induced in at least one ROI. We found a negative association between the magnitude of the iTBS-induced E-fields and RT changes (R = - 0.54, p = 0.04). TBS protocols may lead to changes in CP when applied over the craniometrically targeted vertex. We therefore suggest not using a conventional approach as a vertex targeting method.
ER  -

PIŽEM, Dominik, Ľubomíra NOVÁKOVÁ, Martin GAJDOŠ a Irena REKTOROVÁ. Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls. \textit{Journal of Neural Transmission}. Springer, 2022, roč.~129, č.~3, s.~319-329. ISSN~0300-9564. Dostupné z: https://dx.doi.org/10.1007/s00702-022-02466-9.

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