ZUANI DE, Marco, Petra LÁZNIČKOVÁ, Veronika TOMÁŠKOVÁ, Martina DVONČOVÁ, Giancarlo FORTE, Gorazd Bernard STOKIN, Vladimír ŠRÁMEK, Martin HELÁN a Jan FRIČ. High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19. Scandinavian journal of immunology. HOBOKEN: WILEY, 2022, roč. 95, č. 3, s. 1-11. ISSN 0300-9475. Dostupné z: https://dx.doi.org/10.1111/sji.13125. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1830717, author = {Zuani De, Marco and Lázničková, Petra and Tomášková, Veronika and Dvončová, Martina and Forte, Giancarlo and Stokin, Gorazd Bernard and Šrámek, Vladimír and Helán, Martin and Frič, Jan}, article_location = {HOBOKEN}, article_number = {3}, doi = {http://dx.doi.org/10.1111/sji.13125}, keywords = {CD4-to-CD8 ratio; COVID-19; Intensive care unit; SARS-CoV-2; T cells; TEMRA}, language = {eng}, issn = {0300-9475}, journal = {Scandinavian journal of immunology}, title = {High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19}, url = {https://onlinelibrary.wiley.com/doi/10.1111/sji.13125}, volume = {95}, year = {2022} }
TY - JOUR ID - 1830717 AU - Zuani De, Marco - Lázničková, Petra - Tomášková, Veronika - Dvončová, Martina - Forte, Giancarlo - Stokin, Gorazd Bernard - Šrámek, Vladimír - Helán, Martin - Frič, Jan PY - 2022 TI - High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19 JF - Scandinavian journal of immunology VL - 95 IS - 3 SP - 1-11 EP - 1-11 PB - WILEY SN - 03009475 KW - CD4-to-CD8 ratio KW - COVID-19 KW - Intensive care unit KW - SARS-CoV-2 KW - T cells KW - TEMRA UR - https://onlinelibrary.wiley.com/doi/10.1111/sji.13125 N2 - Around half of people with severe COVID-19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS-CoV-2 differs between ICU patients that recover and those that do not. We conducted whole-blood immunophenotyping of COVID-19 patients upon admission to ICU and during their treatment and uncovered marked differences in their circulating immune cell subsets. At admission, patients who later succumbed to COVID-19 had significantly lower frequencies of all memory CD8+ T cell subsets, resulting in increased CD4-to-CD8 T cell and neutrophil-to-CD8 T cell ratios. ROC and Kaplan-Meier analyses demonstrated that both CD4-to-CD8 and neutrophil-to-CD8 ratios at admission were strong predictors of in-ICU mortality. Therefore, we propose the use of the CD4-to-CD8 T cell ratio as a marker for the early identification of those individuals likely to require enhanced monitoring and/or pro-active intervention in ICU. ER -
ZUANI DE, Marco, Petra LÁZNIČKOVÁ, Veronika TOMÁŠKOVÁ, Martina DVONČOVÁ, Giancarlo FORTE, Gorazd Bernard STOKIN, Vladimír ŠRÁMEK, Martin HELÁN a Jan FRIČ. High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19. \textit{Scandinavian journal of immunology}. HOBOKEN: WILEY, 2022, roč.~95, č.~3, s.~1-11. ISSN~0300-9475. Dostupné z: https://dx.doi.org/10.1111/sji.13125.
|