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@article{1830719, author = {Hortová Kohoutková, Marcela and Zuani De, Marco and Lázničková, Petra and Bendickova, Kamila and Mrkva, Ondřej and Andrejčinová, Ivana and Mýtniková, Alexandra and Polansky, Ondrej and Koci, Kamila and Tomášková, Veronika and Šrámek, Vladimír and Helán, Martin and Frič, Jan}, article_location = {LAUSANNE}, article_number = {December 2021}, doi = {http://dx.doi.org/10.3389/fimmu.2021.741484}, keywords = {sepsis; polymorphonuclears; septic shock; transcriptomics; proteomics; dysfunctionality}, language = {eng}, issn = {1664-3224}, journal = {Frontiers in Immunology}, title = {Polymorphonuclear Cells Show Features of Dysfunctional Activation During Fatal Sepsis}, url = {https://www.frontiersin.org/articles/10.3389/fimmu.2021.741484/full}, volume = {12}, year = {2021} }
TY - JOUR ID - 1830719 AU - Hortová Kohoutková, Marcela - Zuani De, Marco - Lázničková, Petra - Bendickova, Kamila - Mrkva, Ondřej - Andrejčinová, Ivana - Mýtniková, Alexandra - Polansky, Ondrej - Koci, Kamila - Tomášková, Veronika - Šrámek, Vladimír - Helán, Martin - Frič, Jan PY - 2021 TI - Polymorphonuclear Cells Show Features of Dysfunctional Activation During Fatal Sepsis JF - Frontiers in Immunology VL - 12 IS - December 2021 SP - 1-12 EP - 1-12 PB - FRONTIERS MEDIA SA SN - 16643224 KW - sepsis KW - polymorphonuclears KW - septic shock KW - transcriptomics KW - proteomics KW - dysfunctionality UR - https://www.frontiersin.org/articles/10.3389/fimmu.2021.741484/full N2 - Sepsis and septic shock remain leading causes of morbidity and mortality for patients in the intensive care unit. During the early phase, immune cells produce various cytokines leading to prompt activation of the immune system. Polymorphonuclear leukocytes (PMNs) respond to different signals producing inflammatory factors and executing their antimicrobial mechanisms, resulting in the engulfment and elimination of invading pathogens. However, excessive activation caused by various inflammatory signals produced during sepsis progression can lead to the alteration of PMN signaling and subsequent defects in their functionality. Here, we analyzed samples from 34 patients in septic shock, focusing on PMNs gene expression and proteome changes associated with septic shock. We revealed that, compared to those patients who survived longer than five days, PMNs from patients who had fulminant sepsis were characterized by a dysfunctional hyper-activation, show altered metabolism, and recent exit from the cell cycle and signs of cellular lifespan. We believe that this multi-omics approach, although limited, pinpoints the alterations in PMNs' functionality, which may be rescued by targeted treatments. ER -
HORTOVÁ KOHOUTKOVÁ, Marcela, Marco ZUANI DE, Petra LÁZNIČKOVÁ, Kamila BENDICKOVA, Ondřej MRKVA, Ivana ANDREJČINOVÁ, Alexandra MÝTNIKOVÁ, Ondrej POLANSKY, Kamila KOCI, Veronika TOMÁŠKOVÁ, Vladimír ŠRÁMEK, Martin HELÁN a Jan FRIČ. Polymorphonuclear Cells Show Features of Dysfunctional Activation During Fatal Sepsis. \textit{Frontiers in Immunology}. LAUSANNE: FRONTIERS MEDIA SA, 2021, roč.~12, December 2021, s.~1-12. ISSN~1664-3224. Dostupné z: https://dx.doi.org/10.3389/fimmu.2021.741484.
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