Variability assessment of manual segmentations of ischemic
lesion volume on 24-h non-contrast CT

J 2022

Variability assessment of manual segmentations of ischemic lesion volume on 24-h non-contrast CT

CIMFLOVÁ, Petra, J. M. OSPEL, M. MARKO, B. K. MENON, W. QIU et. al.

Základní údaje

Originální název

Variability assessment of manual segmentations of ischemic lesion volume on 24-h non-contrast CT

Autoři

CIMFLOVÁ, Petra (203 Česká republika, domácí), J. M. OSPEL, M. MARKO, B. K. MENON a W. QIU (garant)

Vydání

NEURORADIOLOGY, NEW YORK, SPRINGER, 2022, 0028-3940

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.800

Kód RIV

RIV/00216224:14110/22:00125374

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s00234-021-02855-z

UT WoS

000721656300003

Klíčová slova anglicky

Ischemic stroke; Ischemic lesion volume; Non-contrast CT

Štítky

14110119, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 7. 2022 09:33, Mgr. Tereza Miškechová

Anotace

V originále

Purpose Infarct lesion volume (ILV) may serve as an imaging biomarker for clinical outcomes in the early post-treatment stage in patients with acute ischemic stroke. The aim of this study was to evaluate the inter- and intra-rater reliability of manual segmentation of ILV on follow-up non-contrast CT (NCCT) scans. Methods Fifty patients from the Prove-IT study were randomly selected for this analysis. Three raters manually segmented ILV on 24-h NCCT scans, slice by slice, three times. The reference standard for ILV was generated by the Simultaneous Truth And Performance Level estimation (STAPLE) algorithm. Intra- and inter-rater reliability was evaluated, using metrics of intraclass correlation coefficient (ICC) regarding lesion volume and the Dice similarity coefficient (DSC). Results Median age of the 50 subjects included was 74.5 years (interquartile range [IQR] 67-80), 54% were women, median baseline National Institutes of Health Stroke Scale was 18 (IQR 11-22), median baseline ASPECTS was 9 (IQR 6-10). The mean reference standard ILV was 92.5 ml (standard deviation (SD) +/- 100.9 ml). The manually segmented ILV ranged from 88.2 +/- 91.5 to 135.5 +/- 119.9 ml (means referring to the variation between readers, SD within readers). Inter-rater ICC was 0.83 (95%CI: 0.76-0.88); intra-rater ICC ranged from 0.85 (95%CI: 0.72-0.92) to 0.95 (95%CI: 0.91-0.97). The mean DSC among the three readers ranged from 65.5 +/- 22.9 to 76.4 +/- 17.1% and the mean overall DSC was 72.8 +/- 23.0%. Conclusion Manual ILV measurements on follow-up CT scans are reliable to measure the radiological outcome despite some variability.

Citovat

CIMFLOVÁ, Petra, J. M. OSPEL, M. MARKO, B. K. MENON a W. QIU. Variability assessment of manual segmentations of ischemic lesion volume on 24-h non-contrast CT. NEURORADIOLOGY. NEW YORK: SPRINGER, 2022, roč. 64, č. 6, s. 1165-1173. ISSN 0028-3940. Dostupné z: https://dx.doi.org/10.1007/s00234-021-02855-z.

@article{1834415,
   author = {Cimflová, Petra and Ospel, J. M. and Marko, M. and Menon, B. K. and Qiu, W.},
   article_location = {NEW YORK},
   article_number = {6},
   doi = {http://dx.doi.org/10.1007/s00234-021-02855-z},
   keywords = {Ischemic stroke; Ischemic lesion volume; Non-contrast CT},
   language = {eng},
   issn = {0028-3940},
   journal = {NEURORADIOLOGY},
   title = {Variability assessment of manual segmentations of ischemic lesion volume on 24-h non-contrast CT},
   url = {https://link.springer.com/article/10.1007/s00234-021-02855-z},
   volume = {64},
   year = {2022}
}

TY  - JOUR
ID  - 1834415
AU  - Cimflová, Petra - Ospel, J. M. - Marko, M. - Menon, B. K. - Qiu, W.
PY  - 2022
TI  - Variability assessment of manual segmentations of ischemic lesion volume on 24-h non-contrast CT
JF  - NEURORADIOLOGY
VL  - 64
IS  - 6
SP  - 1165-1173
EP  - 1165-1173
PB  - SPRINGER
SN  - 00283940
KW  - Ischemic stroke
KW  - Ischemic lesion volume
KW  - Non-contrast CT
UR  - https://link.springer.com/article/10.1007/s00234-021-02855-z
N2  - Purpose Infarct lesion volume (ILV) may serve as an imaging biomarker for clinical outcomes in the early post-treatment stage in patients with acute ischemic stroke. The aim of this study was to evaluate the inter- and intra-rater reliability of manual segmentation of ILV on follow-up non-contrast CT (NCCT) scans. Methods Fifty patients from the Prove-IT study were randomly selected for this analysis. Three raters manually segmented ILV on 24-h NCCT scans, slice by slice, three times. The reference standard for ILV was generated by the Simultaneous Truth And Performance Level estimation (STAPLE) algorithm. Intra- and inter-rater reliability was evaluated, using metrics of intraclass correlation coefficient (ICC) regarding lesion volume and the Dice similarity coefficient (DSC). Results Median age of the 50 subjects included was 74.5 years (interquartile range [IQR] 67-80), 54% were women, median baseline National Institutes of Health Stroke Scale was 18 (IQR 11-22), median baseline ASPECTS was 9 (IQR 6-10). The mean reference standard ILV was 92.5 ml (standard deviation (SD) +/- 100.9 ml). The manually segmented ILV ranged from 88.2 +/- 91.5 to 135.5 +/- 119.9 ml (means referring to the variation between readers, SD within readers). Inter-rater ICC was 0.83 (95%CI: 0.76-0.88); intra-rater ICC ranged from 0.85 (95%CI: 0.72-0.92) to 0.95 (95%CI: 0.91-0.97). The mean DSC among the three readers ranged from 65.5 +/- 22.9 to 76.4 +/- 17.1% and the mean overall DSC was 72.8 +/- 23.0%. Conclusion Manual ILV measurements on follow-up CT scans are reliable to measure the radiological outcome despite some variability.
ER  -

CIMFLOVÁ, Petra, J. M. OSPEL, M. MARKO, B. K. MENON a W. QIU. Variability assessment of manual segmentations of ischemic lesion volume on 24-h non-contrast CT. \textit{NEURORADIOLOGY}. NEW YORK: SPRINGER, 2022, roč.~64, č.~6, s.~1165-1173. ISSN~0028-3940. Dostupné z: https://dx.doi.org/10.1007/s00234-021-02855-z.

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