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@article{1834737,
author = {Nadri, G. and Saxena, S. and Kaur, A. and Ahmad, K. and Garg, P. and Mahdi, A. A. and Akduman, L. and Gazdikova, K. and Caprnda, M. and Vesely, P. and Kružliak, Peter and Krasnik, V.},
article_location = {ABINGDON},
article_number = {3},
doi = {http://dx.doi.org/10.1080/16089677.2021.1903170},
keywords = {Diabetic retinopathy (DR); disorganization of retinal inner layer (DRIL); spectral domain optical coherence tomography (SD-OCT); vitamin D},
language = {eng},
issn = {1608-9677},
journal = {JOURNAL OF ENDOCRINOLOGY METABOLISM AND DIABETES OF SOUTH AFRICA},
title = {Correlation between vitamin D serum levels and severity of diabetic retinopathy in patients with type 2 diabetes mellitus},
url = {https://www.tandfonline.com/doi/full/10.1080/16089677.2021.1903170},
volume = {26},
year = {2021}
}
TY - JOUR
ID - 1834737
AU - Nadri, G. - Saxena, S. - Kaur, A. - Ahmad, K. - Garg, P. - Mahdi, A. A. - Akduman, L. - Gazdikova, K. - Caprnda, M. - Vesely, P. - Kružliak, Peter - Krasnik, V.
PY - 2021
TI - Correlation between vitamin D serum levels and severity of diabetic retinopathy in patients with type 2 diabetes mellitus
JF - JOURNAL OF ENDOCRINOLOGY METABOLISM AND DIABETES OF SOUTH AFRICA
VL - 26
IS - 3
SP - 82-88
EP - 82-88
PB - ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
SN - 16089677
KW - Diabetic retinopathy (DR)
KW - disorganization of retinal inner layer (DRIL)
KW - spectral domain optical coherence tomography (SD-OCT)
KW - vitamin D
UR - https://www.tandfonline.com/doi/full/10.1080/16089677.2021.1903170
N2 - Purpose: To study the correlation of serum vitamin D levels with quantitative (central subfield thickness [CST], cube average thickness [CAT]), cross-sectional (disorganisation of retinal inner layer [DRIL] and ellipsoid zone [EZ]) and topographic parameters (retinal pigment epithelium [RPE]) on spectral domain optical coherence tomography (SD-OCT) in diabetic retinopathy (DR), for the first time. Methods: Eighty-eight consecutive cases of type 2 diabetes mellitus with no retinopathy (No DR; n = 22); non-proliferative DR (NPDR; n = 22); proliferative DR (PDR; n = 22) and healthy controls (n = 22) were included, after sample size calculation. On SDOCT, physician-friendly grading systems were created for DRIL, EZ disruption and RPE alterations. Serum vitamin D was analysed using a standard protocol. Statistical analysis was done using Pearson correlation, Student's t-test, ANOVA, Newman-Keuls test, chi-square test and univariate ordinal logistic regression analysis. Results: Mean serum vitamin D levels (ng/ml) were: No DR = 23.36 +/- 2.00, NPDR = 17.88 +/- 1.86, PDR = 14.07 +/- 1.21, and controls = 25.11 +/- 1.59. Low vitamin D levels correlated significantly with severity of retinopathy, VA (r = 0.50), CST (r = 0.36), CAT (r = 0.41), DRIL (r = 0.35), EZ disruption (r =0.40) and RPE alterations (r=0.37), respectively (p <0.01). Significantly low vitamin D levels were observed in subjects with DRIL present versus DRIL absent; EZ disruption, focal versus global versus intact; RPE alterations, focal versus global versus none, respectively (p < 0.05). Conclusions: Low serum vitamin D levels correlate with the presence of DRIL, EZ disruption and RPE alterations and increased severity of DR.
ER -
NADRI, G., S. SAXENA, A. KAUR, K. AHMAD, P. GARG, A. A. MAHDI, L. AKDUMAN, K. GAZDIKOVA, M. CAPRNDA, P. VESELY, Peter KRUŽLIAK and V. KRASNIK. Correlation between vitamin D serum levels and severity of diabetic retinopathy in patients with type 2 diabetes mellitus. \textit{JOURNAL OF ENDOCRINOLOGY METABOLISM AND DIABETES OF SOUTH AFRICA}. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR \&{} FRANCIS LTD, 2021, vol.~26, No~3, p.~82-88. ISSN~1608-9677. Available from: https://dx.doi.org/10.1080/16089677.2021.1903170.
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