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@article{1834763,
author = {Turton, P. and ElandSharkawi, D. and Lyburn, I. and Sharma, B. and Mahalingam, P. and Turner, Suzanne Dawn and MacNeill, F. and Johnson, L. and Hamilton, S. and Burton, C. and Mercer, N.},
article_location = {OXFORD},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.ejso.2020.07.043},
keywords = {BIA-ALCL; Reconstructive breast surgery; Lymphoma; Breast implants; Treatment guidelines},
language = {eng},
issn = {0748-7983},
journal = {EJSO},
title = {UK Guidelines on the Diagnosis and Treatment of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) on behalf of the Medicines and Healthcare products Regulatory Agency (MHRA) Plastic, Reconstructive and Aesthetic Surgery Expert Advisory Group (PRASEAG)},
url = {https://www.sciencedirect.com/science/article/pii/S0748798320306880?via%3Dihub},
volume = {47},
year = {2021}
}
TY - JOUR
ID - 1834763
AU - Turton, P. - El-Sharkawi, D. - Lyburn, I. - Sharma, B. - Mahalingam, P. - Turner, Suzanne Dawn - MacNeill, F. - Johnson, L. - Hamilton, S. - Burton, C. - Mercer, N.
PY - 2021
TI - UK Guidelines on the Diagnosis and Treatment of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) on behalf of the Medicines and Healthcare products Regulatory Agency (MHRA) Plastic, Reconstructive and Aesthetic Surgery Expert Advisory Group (PRASEAG)
JF - EJSO
VL - 47
IS - 2
SP - 199-210
EP - 199-210
PB - ELSEVIER SCI LTD
SN - 07487983
KW - BIA-ALCL
KW - Reconstructive breast surgery
KW - Lymphoma
KW - Breast implants
KW - Treatment guidelines
UR - https://www.sciencedirect.com/science/article/pii/S0748798320306880?via%3Dihub
N2 - Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon T cell Non-Hodgkin Lymphoma ( NHL) associated with breast implants. Raising awareness of the possibility of BIA-ALCL in anyone with breast implants and new breast symptoms is crucial to early diagnosis. The tumour begins on the inner aspect of the peri-implant capsule causing an effusion, or less commonly a tissue mass to form within the capsule, which may spread locally or to more distant sites in the body. Diagnosis is usually made by cytological, immunohistochemical and immunophenotypic evaluation of the aspirated peri-implant fluid: pleomorphic lymphocytes are characteristically anaplastic lymphoma kinase (ALK) negative and strongly positive for CD30. BIA-ALCL is indolent in most patients but can progress rapidly. Surgical removal of the implant with the intact surrounding capsule (total en-bloc capsulectomy) is usually curative. Late diagnosis may require more radical surgery and systemic therapies and although these are usually successful, poor outcomes and deaths have been reported. By adopting a structured approach, as suggested in these guidelines, early diagnosis and successful treatment will minimize the need for systemic treatments, reduce morbidity and the risk of poor outcomes. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of Elsevier Ltd, British Association of Surgical Oncology & European Society of Surgical Oncology; published by Wiley on behalf of John Wiley and Sons Limited; and published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons. All rights reserved.
ER -
TURTON, P., D. EL-SHARKAWI, I. LYBURN, B. SHARMA, P. MAHALINGAM, Suzanne Dawn TURNER, F. MACNEILL, L. JOHNSON, S. HAMILTON, C. BURTON a N. MERCER. UK Guidelines on the Diagnosis and Treatment of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) on behalf of the Medicines and Healthcare products Regulatory Agency (MHRA) Plastic, Reconstructive and Aesthetic Surgery Expert Advisory Group (PRASEAG). \textit{EJSO}. OXFORD: ELSEVIER SCI LTD, 2021, roč.~47, č.~2, s.~199-210. ISSN~0748-7983. Dostupné z: https://dx.doi.org/10.1016/j.ejso.2020.07.043.
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