Self-renewal in induced pluripotent stem cells

BÁRTA, Tomáš, Dáša BOHAČIAKOVÁ a Lukáš ČAJÁNEK. Self-renewal in induced pluripotent stem cells. In Recent Advances in iPSC Technology. 2021, s. 179-207, 28 s. ISBN 978-0-12-822231-7. Dostupné z: https://dx.doi.org/10.1016/B978-0-12-822231-7.00007-2.

Základní údaje

Originální název

Self-renewal in induced pluripotent stem cells

Název anglicky

Self-renewal in induced pluripotent stem cells

Autoři

BÁRTA, Tomáš, Dáša BOHAČIAKOVÁ a Lukáš ČAJÁNEK

Vydání

Recent Advances in iPSC Technology, od s. 179-207, 28 s. 2021

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Další údaje

Typ výsledku

Kapitola resp. kapitoly v odborné knize

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

ISBN

978-0-12-822231-7

DOI

http://dx.doi.org/10.1016/B978-0-12-822231-7.00007-2

Klíčová slova anglicky

Cell cycle; Checkpoint; Differentiation; Growth factor; Noncoding RNA; Pluripotency; Proliferation; Reprogramming; Self-renewal; Signaling; Stem cell; Telomereses

Příznaky

Mezinárodní význam

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Anotace

V originále

Human induced pluripotent stem cells (hiPSCs) hold great promise in the fields of regenerative medicine and disease modeling. In order to fully exploit the regenerative potential of hiPSCs through efficient, safe, and cost-effective production and maintenance of these cells, it is vital to have a firm understanding of the molecular processes responsible for their unique properties. hiPSCs rely on mechanisms similar to those in human embryonic stem cells to maintain their pluripotency and to control their differentiation (Vallier et al., 2009). In this chapter, we thoroughly discuss the current understanding of the key players and principles orchestrating effective self-renewal of hiPSCs, namely the mechanisms and consequences of cell cycle regulation and the role of growth factors, noncoding RNAs, and telomeres.

Anglicky

Human induced pluripotent stem cells (hiPSCs) hold great promise in the fields of regenerative medicine and disease modeling. In order to fully exploit the regenerative potential of hiPSCs through efficient, safe, and cost-effective production and maintenance of these cells, it is vital to have a firm understanding of the molecular processes responsible for their unique properties. hiPSCs rely on mechanisms similar to those in human embryonic stem cells to maintain their pluripotency and to control their differentiation (Vallier et al., 2009). In this chapter, we thoroughly discuss the current understanding of the key players and principles orchestrating effective self-renewal of hiPSCs, namely the mechanisms and consequences of cell cycle regulation and the role of growth factors, noncoding RNAs, and telomeres.