The genetic and epigenetic landscape of the Arabidopsis
centromeres

J 2021

The genetic and epigenetic landscape of the Arabidopsis centromeres

NAISH, M., M. ALONGE, P. WLODZIMIERZ, A.J. TOCK, B.W. ABRAMSON et. al.

Základní údaje

Originální název

The genetic and epigenetic landscape of the Arabidopsis centromeres

Autoři

NAISH, M., M. ALONGE, P. WLODZIMIERZ, A.J. TOCK, B.W. ABRAMSON, A. SCHMUCKER, Terezie MALÍK MANDÁKOVÁ (203 Česká republika, domácí), B. JAMGE, C. LAMBING, P. KUO, N. YELINA, N. HARTWICK, K. COLT, L.M. SMITH, J. TON, T. KAKUTANI, R.A. MARTIENSSEN, K. SCHNEEBERGER, Martin LYSÁK (203 Česká republika, garant, domácí), F. BERGER, A. BOUSIOS, T.P. MICHAEL, M.C. SCHATZ a I.R. HENDERSON

Vydání

Science, WASHINGTON, AMER ASSOC ADVANCEMENT SCIENCE, 2021, 0036-8075

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10611 Plant sciences, botany

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 63.714

Kód RIV

RIV/00216224:14740/21:00119657

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1126/science.abi7489

UT WoS

000717915400028

Klíčová slova anglicky

HUMAN X-CHROMOSOME; TRANSPOSABLE ELEMENTS; SEQUENCE ORGANIZATION; READ ALIGNMENT; WILD-TYPE; GENOME; CHROMATIN; LOCALIZATION; SATELLITE; EVOLUTION

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 2. 2022 10:39, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Centromeres attach chromosomes to spindle microtubules during cell division and, despite this conserved role, show paradoxically rapid evolution and are typified by complex repeats. We used long-read sequencing to generate the Col-CEN Arabidopsis thaliana genome assembly that resolves all five centromeres. The centromeres consist of megabase-scale tandemly repeated satellite arrays, which support CENTROMERE SPECIFIC HISTONE H3 (CENH3) occupancy and are densely DNA methylated, with satellite variants private to each chromosome. CENH3 preferentially occupies satellites that show the least amount of divergence and occur in higher-order repeats. The centromeres are invaded by ATHILA retrotransposons, which disrupt genetic and epigenetic organization. Centromeric crossover recombination is suppressed, yet low levels of meiotic DNA double-strand breaks occur that are regulated by DNA methylation. We propose that Arabidopsis centromeres are evolving through cycles of satellite homogenization and retrotransposon-driven diversification.

Návaznosti

GA21-03909S, projekt VaV

Název: Odhalení evolučních tajů lničky seté a příbuzných druhů

Investor: Grantová agentura ČR, Odhalení evolučních tajů lničky seté a příbuzných druhů

Citovat

NAISH, M., M. ALONGE, P. WLODZIMIERZ, A.J. TOCK, B.W. ABRAMSON, A. SCHMUCKER, Terezie MALÍK MANDÁKOVÁ, B. JAMGE, C. LAMBING, P. KUO, N. YELINA, N. HARTWICK, K. COLT, L.M. SMITH, J. TON, T. KAKUTANI, R.A. MARTIENSSEN, K. SCHNEEBERGER, Martin LYSÁK, F. BERGER, A. BOUSIOS, T.P. MICHAEL, M.C. SCHATZ a I.R. HENDERSON. The genetic and epigenetic landscape of the Arabidopsis centromeres. Science. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE, 2021, roč. 374, č. 6569, s. "840"-"+", 88 s. ISSN 0036-8075. Dostupné z: https://dx.doi.org/10.1126/science.abi7489.

@article{1835921,
   author = {Naish, M. and Alonge, M. and Wlodzimierz, P. and Tock, A.J. and Abramson, B.W. and Schmucker, A. and Malík Mandáková, Terezie and Jamge, B. and Lambing, C. and Kuo, P. and Yelina, N. and Hartwick, N. and Colt, K. and Smith, L.M. and Ton, J. and Kakutani, T. and Martienssen, R.A. and Schneeberger, K. and Lysák, Martin and Berger, F. and Bousios, A. and Michael, T.P. and Schatz, M.C. and Henderson, I.R.},
   article_location = {WASHINGTON},
   article_number = {6569},
   doi = {http://dx.doi.org/10.1126/science.abi7489},
   keywords = {HUMAN X-CHROMOSOME; TRANSPOSABLE ELEMENTS; SEQUENCE ORGANIZATION; READ ALIGNMENT; WILD-TYPE; GENOME; CHROMATIN; LOCALIZATION; SATELLITE; EVOLUTION},
   language = {eng},
   issn = {0036-8075},
   journal = {Science},
   title = {The genetic and epigenetic landscape of the Arabidopsis centromeres},
   url = {https://www.science.org/doi/10.1126/science.abi7489},
   volume = {374},
   year = {2021}
}

TY  - JOUR
ID  - 1835921
AU  - Naish, M. - Alonge, M. - Wlodzimierz, P. - Tock, A.J. - Abramson, B.W. - Schmucker, A. - Malík Mandáková, Terezie - Jamge, B. - Lambing, C. - Kuo, P. - Yelina, N. - Hartwick, N. - Colt, K. - Smith, L.M. - Ton, J. - Kakutani, T. - Martienssen, R.A. - Schneeberger, K. - Lysák, Martin - Berger, F. - Bousios, A. - Michael, T.P. - Schatz, M.C. - Henderson, I.R.
PY  - 2021
TI  - The genetic and epigenetic landscape of the Arabidopsis centromeres
JF  - Science
VL  - 374
IS  - 6569
SP  - "840"-"+"
EP  - "840"-"+"
PB  - AMER ASSOC ADVANCEMENT SCIENCE
SN  - 00368075
KW  - HUMAN X-CHROMOSOME
KW  - TRANSPOSABLE ELEMENTS
KW  - SEQUENCE ORGANIZATION
KW  - READ ALIGNMENT
KW  - WILD-TYPE
KW  - GENOME
KW  - CHROMATIN
KW  - LOCALIZATION
KW  - SATELLITE
KW  - EVOLUTION
UR  - https://www.science.org/doi/10.1126/science.abi7489
N2  - Centromeres attach chromosomes to spindle microtubules during cell division and, despite this conserved role, show paradoxically rapid evolution and are typified by complex repeats. We used long-read sequencing to generate the Col-CEN Arabidopsis thaliana genome assembly that resolves all five centromeres. The centromeres consist of megabase-scale tandemly repeated satellite arrays, which support CENTROMERE SPECIFIC HISTONE H3 (CENH3) occupancy and are densely DNA methylated, with satellite variants private to each chromosome. CENH3 preferentially occupies satellites that show the least amount of divergence and occur in higher-order repeats. The centromeres are invaded by ATHILA retrotransposons, which disrupt genetic and epigenetic organization. Centromeric crossover recombination is suppressed, yet low levels of meiotic DNA double-strand breaks occur that are regulated by DNA methylation. We propose that Arabidopsis centromeres are evolving through cycles of satellite homogenization and retrotransposon-driven diversification.
ER  -

NAISH, M., M. ALONGE, P. WLODZIMIERZ, A.J. TOCK, B.W. ABRAMSON, A. SCHMUCKER, Terezie MALÍK MANDÁKOVÁ, B. JAMGE, C. LAMBING, P. KUO, N. YELINA, N. HARTWICK, K. COLT, L.M. SMITH, J. TON, T. KAKUTANI, R.A. MARTIENSSEN, K. SCHNEEBERGER, Martin LYSÁK, F. BERGER, A. BOUSIOS, T.P. MICHAEL, M.C. SCHATZ a I.R. HENDERSON. The genetic and epigenetic landscape of the Arabidopsis centromeres. \textit{Science}. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE, 2021, roč.~374, č.~6569, s.~''840''-''+'', 88 s. ISSN~0036-8075. Dostupné z: https://dx.doi.org/10.1126/science.abi7489.

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