Target-Specific Magnetic Resonance Imaging of Human Prostate
Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles

J 2021

Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles

DASH, A., B. BLASIAK, Boguslaw TOMANEK, Peter LATTA, FCJM. VAN VEGGEL et. al.

Základní údaje

Originální název

Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles

Autoři

DASH, A., B. BLASIAK, Boguslaw TOMANEK (616 Polsko, domácí), Peter LATTA (703 Slovensko, garant, domácí) a FCJM. VAN VEGGEL

Vydání

ACS APPLIED MATERIALS & INTERFACES, WASHINGTON, AMER CHEMICAL SOC, 2021, 1944-8244

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

20601 Medical engineering

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 10.383

Kód RIV

RIV/00216224:14740/21:00124240

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1021/acsami.0c19273

UT WoS

000659315800001

Klíčová slova anglicky

anti-PSMA; MRI; relaxivity; nanoparticle; paramagnetic; dysprosium; gadlinium; EPR

Štítky

CF MAFIL, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 10. 2024 13:04, Ing. Jana Kuchtová

Anotace

V originále

We illustrate the development of NaDyF4-NaGdF4 core-shell nanoparticles (NPs) for targeting prostate cancer cells using a preclinical 9.4 T magnetic resonance imaging (MRI) of live animals. The NPs composed of paramagnetic Dy3+ and Gd3+ (T-2- and T-1-contrast agents, respectively) demonstrate proton relaxivities of r(1) = 20.2 mM(-1) s(-1) and r(2) = 32.3 mM(-1) s(-1) at clinical 3 T and r(1) = 9.4 mM(-1) s(-1) and r(2) = 144.7 mM(-1) s(-1) at preclinical 9.4 T. The corresponding relaxivity values per NP are r(1) = 19.4 x 105 mM(NP)(-1) s(-1) and r(2) = 33.0 x 10(5) mMNP(-1) s(-1) at 3 T and r(1) = 9.0 x 105 mM(NP)(-1) s(-1) and r(2) = 147.0 x 10(5) mM(NP)(-1) s(-1) at 9.4 T. In vivo active targeting of human prostate tumors grown in nude mice revealed docking of anti-prostate-specific membrane antigen (PSMA) antibody-tagged NPs at tumor sites post-24 h of their intravenous injection. On the other hand, in vivo passive targeting showed preferential accumulation of NPs at tumor sites only within 2 h of their injection, ascribed to the enhanced permeation and retention effect of the tumor. A biodistribution study employing the harvested organs of mice, post-24 h injection of NPs, quantified active targeting as nearly twice as efficient as passive targeting. These outcomes provide potential opportunities for noninvasive diagnosis using NaDyF4-NaGdF4 core-shell NPs for target-specific MRI.

Návaznosti

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

DASH, A., B. BLASIAK, Boguslaw TOMANEK, Peter LATTA a FCJM. VAN VEGGEL. Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles. ACS APPLIED MATERIALS & INTERFACES. WASHINGTON: AMER CHEMICAL SOC, 2021, roč. 13, č. 21, s. 24345-24355. ISSN 1944-8244. Dostupné z: https://dx.doi.org/10.1021/acsami.0c19273.

@article{1836119,
   author = {Dash, A. and Blasiak, B. and Tomanek, Boguslaw and Latta, Peter and van Veggel, FCJM.},
   article_location = {WASHINGTON},
   article_number = {21},
   doi = {http://dx.doi.org/10.1021/acsami.0c19273},
   keywords = {anti-PSMA; MRI; relaxivity; nanoparticle; paramagnetic; dysprosium; gadlinium; EPR},
   language = {eng},
   issn = {1944-8244},
   journal = {ACS APPLIED MATERIALS & INTERFACES},
   title = {Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles},
   url = {https://pubs.acs.org/doi/10.1021/acsami.0c19273},
   volume = {13},
   year = {2021}
}

TY  - JOUR
ID  - 1836119
AU  - Dash, A. - Blasiak, B. - Tomanek, Boguslaw - Latta, Peter - van Veggel, FCJM.
PY  - 2021
TI  - Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles
JF  - ACS APPLIED MATERIALS & INTERFACES
VL  - 13
IS  - 21
SP  - 24345-24355
EP  - 24345-24355
PB  - AMER CHEMICAL SOC
SN  - 19448244
KW  - anti-PSMA
KW  - MRI
KW  - relaxivity
KW  - nanoparticle
KW  - paramagnetic
KW  - dysprosium
KW  - gadlinium
KW  - EPR
UR  - https://pubs.acs.org/doi/10.1021/acsami.0c19273
N2  - We illustrate the development of NaDyF4-NaGdF4 core-shell nanoparticles (NPs) for targeting prostate cancer cells using a preclinical 9.4 T magnetic resonance imaging (MRI) of live animals. The NPs composed of paramagnetic Dy3+ and Gd3+ (T-2- and T-1-contrast agents, respectively) demonstrate proton relaxivities of r(1) = 20.2 mM(-1) s(-1) and r(2) = 32.3 mM(-1) s(-1) at clinical 3 T and r(1) = 9.4 mM(-1) s(-1) and r(2) = 144.7 mM(-1) s(-1) at preclinical 9.4 T. The corresponding relaxivity values per NP are r(1) = 19.4 x 105 mM(NP)(-1) s(-1) and r(2) = 33.0 x 10(5) mMNP(-1) s(-1) at 3 T and r(1) = 9.0 x 105 mM(NP)(-1) s(-1) and r(2) = 147.0 x 10(5) mM(NP)(-1) s(-1) at 9.4 T. In vivo active targeting of human prostate tumors grown in nude mice revealed docking of anti-prostate-specific membrane antigen (PSMA) antibody-tagged NPs at tumor sites post-24 h of their intravenous injection. On the other hand, in vivo passive targeting showed preferential accumulation of NPs at tumor sites only within 2 h of their injection, ascribed to the enhanced permeation and retention effect of the tumor. A biodistribution study employing the harvested organs of mice, post-24 h injection of NPs, quantified active targeting as nearly twice as efficient as passive targeting. These outcomes provide potential opportunities for noninvasive diagnosis using NaDyF4-NaGdF4 core-shell NPs for target-specific MRI.
ER  -

DASH, A., B. BLASIAK, Boguslaw TOMANEK, Peter LATTA a FCJM. VAN VEGGEL. Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles. \textit{ACS APPLIED MATERIALS \&{}amp; INTERFACES}. WASHINGTON: AMER CHEMICAL SOC, 2021, roč.~13, č.~21, s.~24345-24355. ISSN~1944-8244. Dostupné z: https://dx.doi.org/10.1021/acsami.0c19273.

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