Copper(II) Phenanthroline-Based Complexes as Potential
AntiCancer Drugs: A Walkthrough on the Mechanisms of Action

J 2022

Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action

MASURI, Sebastiano, Petr VAŇHARA, Maria Grazia CABIDDU, Lukáš MORÁŇ, Josef HAVEL et. al.

Základní údaje

Originální název

Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action

Autoři

MASURI, Sebastiano (garant), Petr VAŇHARA (203 Česká republika, domácí), Maria Grazia CABIDDU, Lukáš MORÁŇ (203 Česká republika, domácí), Josef HAVEL (203 Česká republika, domácí), Enzo CADONI a Tiziana PIVETTA

Vydání

Molecules, Basel, MDPI, 2022, 1420-3049

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10401 Organic chemistry

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.600

Kód RIV

RIV/00216224:14110/22:00125429

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/molecules27010049

UT WoS

000755482700001

Klíčová slova anglicky

cancer; coordination compounds; copper; 1-10-phenanthroline; anticancer chemotherapy; chemoresistance; cell stress response

Štítky

14110517, rivok

Změněno: 2. 2. 2023 13:41, Mgr. Tereza Miškechová

Anotace

V originále

Copper is an endogenous metal ion that has been studied to prepare a new antitumoral agent with less side-effects. Copper is involved as a cofactor in several enzymes, in ROS production, in the promotion of tumor progression, metastasis, and angiogenesis, and has been found at high levels in serum and tissues of several types of human cancers. Under these circumstances, two strategies are commonly followed in the development of novel anticancer Copper-based drugs: the sequestration of free Copper ions and the synthesis of Copper complexes that trigger cell death. The latter strategy has been followed in the last 40 years and many reviews have covered the anticancer properties of a broad spectrum of Copper complexes, showing that the activity of these compounds is often multi factored. In this work, we would like to focus on the anticancer properties of mixed Cu(II) complexes bearing substituted or unsubstituted 1,10-phenanthroline based ligands and different classes of inorganic and organic auxiliary ligands. For each metal complex, information regarding the tested cell lines and the mechanistic studies will be reported and discussed. The exerted action mechanisms were presented according to the auxiliary ligand/s, the metallic centers, and the increasing complexity of the compound structures.

Návaznosti

MUNI/A/1390/2020, interní kód MU

Název: Analytická a fyzikální chemie ve výzkumu biologických, geologických a syntetických materiálů (Akronym: BIOGEOSYNT)

Investor: Masarykova univerzita, Analytická a fyzikální chemie ve výzkumu biologických, geologických a syntetických materiálů

MUNI/A/1689/2020, interní kód MU

Název: Zdroje pro tkáňové inženýrství 11 (Akronym: TissueEng 11)

Investor: Masarykova univerzita, Zdroje pro tkáňové inženýrství 11

ROZV/28/LF23/2020, interní kód MU

Název: Objasněni vlivu ztráty TUSC3 na změnu fenotypových vlastnosti buněk ovariálního povrchového epitelu.

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Objasněni vlivu ztráty TUSC3 na změnu fenotypových vlastností buněk ovariálního povrchového epitelu., Interní rozvojové projekty

Citovat

MASURI, Sebastiano, Petr VAŇHARA, Maria Grazia CABIDDU, Lukáš MORÁŇ, Josef HAVEL, Enzo CADONI a Tiziana PIVETTA. Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action. Molecules. Basel: MDPI, 2022, roč. 27, č. 1, s. 1-26. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules27010049.

@article{1836617,
   author = {Masuri, Sebastiano and Vaňhara, Petr and Cabiddu, Maria Grazia and Moráň, Lukáš and Havel, Josef and Cadoni, Enzo and Pivetta, Tiziana},
   article_location = {Basel},
   article_number = {1},
   doi = {http://dx.doi.org/10.3390/molecules27010049},
   keywords = {cancer; coordination compounds; copper; 1-10-phenanthroline; anticancer chemotherapy; chemoresistance; cell stress response},
   language = {eng},
   issn = {1420-3049},
   journal = {Molecules},
   title = {Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action},
   url = {https://www.mdpi.com/1420-3049/27/1/49/htm},
   volume = {27},
   year = {2022}
}

TY  - JOUR
ID  - 1836617
AU  - Masuri, Sebastiano - Vaňhara, Petr - Cabiddu, Maria Grazia - Moráň, Lukáš - Havel, Josef - Cadoni, Enzo - Pivetta, Tiziana
PY  - 2022
TI  - Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action
JF  - Molecules
VL  - 27
IS  - 1
SP  - 1-26
EP  - 1-26
PB  - MDPI
SN  - 14203049
KW  - cancer
KW  - coordination compounds
KW  - copper
KW  - 1-10-phenanthroline
KW  - anticancer chemotherapy
KW  - chemoresistance
KW  - cell stress response
UR  - https://www.mdpi.com/1420-3049/27/1/49/htm
N2  - Copper is an endogenous metal ion that has been studied to prepare a new antitumoral agent with less side-effects. Copper is involved as a cofactor in several enzymes, in ROS production, in the promotion of tumor progression, metastasis, and angiogenesis, and has been found at high levels in serum and tissues of several types of human cancers. Under these circumstances, two strategies are commonly followed in the development of novel anticancer Copper-based drugs: the sequestration of free Copper ions and the synthesis of Copper complexes that trigger cell death. The latter strategy has been followed in the last 40 years and many reviews have covered the anticancer properties of a broad spectrum of Copper complexes, showing that the activity of these compounds is often multi factored. In this work, we would like to focus on the anticancer properties of mixed Cu(II) complexes bearing substituted or unsubstituted 1,10-phenanthroline based ligands and different classes of inorganic and organic auxiliary ligands. For each metal complex, information regarding the tested cell lines and the mechanistic studies will be reported and discussed. The exerted action mechanisms were presented according to the auxiliary ligand/s, the metallic centers, and the increasing complexity of the compound structures.
ER  -

MASURI, Sebastiano, Petr VAŇHARA, Maria Grazia CABIDDU, Lukáš MORÁŇ, Josef HAVEL, Enzo CADONI a Tiziana PIVETTA. Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action. \textit{Molecules}. Basel: MDPI, 2022, roč.~27, č.~1, s.~1-26. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules27010049.

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