Další formáty:
BibTeX
LaTeX
RIS
@article{1836825,
author = {Věžník, Jakub and Konhefr, Martin and Fohlerová, Zdenka and Lacina, Karel},
article_location = {NEW YORK},
article_number = {November 2021},
doi = {http://dx.doi.org/10.1016/j.jinorgbio.2021.111561},
keywords = {Aminoferrocene; Redox-dependent cytotoxicity; ROS-activated prodrugs; Ferrocenyliminoboronates; MG-63; Electrochemical characterization},
language = {eng},
issn = {0162-0134},
journal = {Journal of Inorganic Biochemistry},
title = {Redox-dependent cytotoxicity of ferrocene derivatives and ROS-activated prodrugs based on ferrocenyliminoboronates},
url = {https://www.sciencedirect.com/science/article/pii/S0162013421002087?via%3Dihub},
volume = {224},
year = {2021}
}
TY - JOUR
ID - 1836825
AU - Věžník, Jakub - Konhefr, Martin - Fohlerová, Zdenka - Lacina, Karel
PY - 2021
TI - Redox-dependent cytotoxicity of ferrocene derivatives and ROS-activated prodrugs based on ferrocenyliminoboronates
JF - Journal of Inorganic Biochemistry
VL - 224
IS - November 2021
SP - 1-8
EP - 1-8
PB - Elsevier
SN - 01620134
KW - Aminoferrocene
KW - Redox-dependent cytotoxicity
KW - ROS-activated prodrugs
KW - Ferrocenyliminoboronates
KW - MG-63
KW - Electrochemical characterization
UR - https://www.sciencedirect.com/science/article/pii/S0162013421002087?via%3Dihub
N2 - Four ferrocene derivatives - ferrocenecarboxylic acid, ferrocenium salt, ferroceneboronic acid, and amino-ferrocene - were characterized electrochemically, and their cytotoxicity was probed using cancer cells (line MG -63). We related the observed cytotoxicity with the determined redox potentials of these four ferrocenes - ami-noferrocene with its lowest redox potential exhibited the highest cytotoxicity. Thus, we synthesized four de-rivatives consisting of aminoferrocene and phenylboronic acid residue with the intent to employ them as ROS-activated prodrugs (ROS - reactive oxygen species). We characterized them and studied their time-dependent stability in aqueous environments. Then, we performed electrochemical measurements at oxidative conditions to confirm ROS-responsivity of the synthesized molecules. Finally, the cytotoxicity of the synthesized molecules was tested using cancer MG-63 cells and noncancerous NIH-3T3 cells. The experiments revealed sought behaviour, especially for para-regioisomers of synthesized ferrocenyliminoboronates.
ER -
VĚŽNÍK, Jakub, Martin KONHEFR, Zdenka FOHLEROVÁ a Karel LACINA. Redox-dependent cytotoxicity of ferrocene derivatives and ROS-activated prodrugs based on ferrocenyliminoboronates. \textit{Journal of Inorganic Biochemistry}. NEW YORK: Elsevier, 2021, roč.~224, November 2021, s.~1-8. ISSN~0162-0134. Dostupné z: https://dx.doi.org/10.1016/j.jinorgbio.2021.111561.
|
