EEKHOUT, T., Martina DVOŘÁČKOVÁ, J.A.P. GARCIA, Martina NEŠPOR DADEJOVÁ, P. KALHORZADEH, H. VAN DEN DAELE, I. VERCAUTEREN, Jiří FAJKUS a L. DE VEYLDER. G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability. Plant Physiology. ROCKVILLE: American Society of Plant Physiologists, 2021, roč. 186, č. 4, s. 1893-1907. ISSN 0032-0889. Dostupné z: https://dx.doi.org/10.1093/plphys/kiab201. |
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@article{1837260, author = {Eekhout, T. and Dvořáčková, Martina and Garcia, J.A.P. and Nešpor Dadejová, Martina and Kalhorzadeh, P. and Van den Daele, H. and Vercauteren, I. and Fajkus, Jiří and De Veylder, L.}, article_location = {ROCKVILLE}, article_number = {4}, doi = {http://dx.doi.org/10.1093/plphys/kiab201}, keywords = {DNA-DAMAGE RESPONSEDEPENDENT KINASE INHIBITORSASSEMBLY FACTOR-IARABIDOPSIS-THALIANAHOMOLOGOUS RECOMBINATION45S RDNACAF-1ATRREPLICATIONDIFFERENTIATION}, language = {eng}, issn = {0032-0889}, journal = {Plant Physiology}, title = {G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability}, url = {https://academic.oup.com/plphys/article/186/4/1893/6270794}, volume = {186}, year = {2021} }
TY - JOUR ID - 1837260 AU - Eekhout, T. - Dvořáčková, Martina - Garcia, J.A.P. - Nešpor Dadejová, Martina - Kalhorzadeh, P. - Van den Daele, H. - Vercauteren, I. - Fajkus, Jiří - De Veylder, L. PY - 2021 TI - G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability JF - Plant Physiology VL - 186 IS - 4 SP - 1893-1907 EP - 1893-1907 PB - American Society of Plant Physiologists SN - 00320889 KW - DNA-DAMAGE RESPONSEDEPENDENT KINASE INHIBITORSASSEMBLY FACTOR-IARABIDOPSIS-THALIANAHOMOLOGOUS RECOMBINATION45S RDNACAF-1ATRREPLICATIONDIFFERENTIATION UR - https://academic.oup.com/plphys/article/186/4/1893/6270794 N2 - The WEE1 and ATM AND RAD3-RELATED (ATR) kinases are important regulators of the plant intra-S-phase checkpoint; consequently, WEE1(KO) and ATR(KO) roots are hypersensitive to replication-inhibitory drugs. Here, we report on a loss-of-function mutant allele of the FASCIATA1 (FAS1) subunit of the chromatin assembly factor 1 (CAF-1) complex that suppresses the phenotype of WEE1- or ATR-deficient Arabidopsis (Arabidopsis thaliana) plants. We demonstrate that lack of FAS1 activity results in the activation of an ATAXIA TELANGIECTASIA MUTATED (ATM)- and SUPPRESSOR OF GAMMA-RESPONSE 1 (SOG1)-mediated G2/M-arrest that renders the ATR and WEE1 checkpoint regulators redundant. This ATM activation accounts for the telomere erosion and loss of ribosomal DNA that are described for fast plants. Knocking out SOG1 in the fast weel background restores replication stress sensitivity, demonstrating that SOG1 is an important secondary checkpoint regulator in plants that fail to activate the intra-S-phase checkpoint. ER -
EEKHOUT, T., Martina DVOŘÁČKOVÁ, J.A.P. GARCIA, Martina NEŠPOR DADEJOVÁ, P. KALHORZADEH, H. VAN DEN DAELE, I. VERCAUTEREN, Jiří FAJKUS a L. DE VEYLDER. G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability. \textit{Plant Physiology}. ROCKVILLE: American Society of Plant Physiologists, 2021, roč.~186, č.~4, s.~1893-1907. ISSN~0032-0889. Dostupné z: https://dx.doi.org/10.1093/plphys/kiab201.
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