Background Lopinavir/ritonavir, lopinavir/ritonavir-interferon (IFN)-β-1a and hydroxychloroquine efficacy for COVID-19 have been evaluated, but detailed evaluation is lacking. Objective To determine the efficacy of lopinavir/ritonavir, lopinavir/ritonavir-IFN-β-1a, hydroxychloroquine or remdesivir for improving the clinical, virological outcomes in COVID-19 inpatients. Design Open-label, randomized, adaptive, controlled trial.
ADER, Florence; Nathan PEIFFER-SMADJA; Julien POISSY; Maude BOUSCAMBERT-DUCHAMP; Drifa BELHADI; Alpha DIALLO; Christelle DELMAS; Juliette SAILLARD; Aline DECHANET; Noémie MERCIER; Axelle DUPONT; Toni ALFAIATE; François-Xavier LESCURE; François RAFFI; François GOEHRINGER; Antoine KIMMOUN; Stéphane JAUREGUIBERRY; Jean REIGNIER; Saad NSEIR; François DANION; Raphael CLERE-JEHL; Kévin BOUILLER; Jean-Christophe NAVELLOU; Violaine TOLSMA; André CABIE; Clément DUBOST; Johan COURJON; Sylvie LEROY; Joy MOOTIEN; Rostane GACI; Bruno MOURVILLIER; Emmanuel FAURE; Valérie POURCHER; Sébastien GALLIEN; Odile LAUNAY; Karine LACOMBE; Jean-Philippe LANOIX; Alain MAKINSON; Guillaume MARTIN-BLONDEL; Lila BOUADMA; Elisabeth BOTELHO-NEVERS; Amandine GAGNEUX-BRUNON; Olivier EPAULARD; Lionel PIROTH; Florent WALLET; Jean-Christophe RICHARD; Jean REUTER; Thérèse STAUB; Maya HITES; Marion NORET; Claire ANDREJAK; Gilles PEYTAVIN; Bruno LINA; Dominique COSTAGLIOLA; Yazdan YAZDANPANAH; Charles BURDET a France MENTRE. Antiviral drugs in hospitalized patients with COVID-19 - the DisCoVeRy trial. medRxiv 20218149 [Preprint]. London: Cold Spring Harbor Laboratory Press, 2021, roč. 2021, č. 1, s. 1-31. ISSN 1756-1833. Dostupné z: https://dx.doi.org/10.1101/2021.01.08.20248149.
@article{1837969, author = {Ader, Florence and PeifferandSmadja, Nathan and Poissy, Julien and BouscambertandDuchamp, Maude and Belhadi, Drifa and Diallo, Alpha and Delmas, Christelle and Saillard, Juliette and Dechanet, Aline and Mercier, Noémie and Dupont, Axelle and Alfaiate, Toni and Lescure, FrançoisandXavier and Raffi, François and Goehringer, François and Kimmoun, Antoine and Jaureguiberry, Stéphane and Reignier, Jean and Nseir, Saad and Danion, François and ClereandJehl, Raphael and Bouiller, Kévin and Navellou, JeanandChristophe and Tolsma, Violaine and Cabie, André and Dubost, Clément and Courjon, Johan and Leroy, Sylvie and Mootien, Joy and Gaci, Rostane and Mourvillier, Bruno and Faure, Emmanuel and Pourcher, Valérie and Gallien, Sébastien and Launay, Odile and Lacombe, Karine and Lanoix, JeanandPhilippe and Makinson, Alain and MartinandBlondel, Guillaume and Bouadma, Lila and BotelhoandNevers, Elisabeth and GagneuxandBrunon, Amandine and Epaulard, Olivier and Piroth, Lionel and Wallet, Florent and Richard, JeanandChristophe and Reuter, Jean and Staub, Thérèse and Hites, Maya and Noret, Marion and Andrejak, Claire and Peytavin, Gilles and Lina, Bruno and Costagliola, Dominique and Yazdanpanah, Yazdan and Burdet, Charles and Mentre, France}, article_location = {London}, article_number = {1}, doi = {http://dx.doi.org/10.1101/2021.01.08.20248149}, keywords = {COVID-19; SARS-CoV-2; hydroxychloroquine; interferon beta-1a; lopinavir/ritonavir; randomized controlled trial}, language = {eng}, issn = {1756-1833}, journal = {medRxiv 20218149 [Preprint]}, note = {EU-RESPONSE}, title = {Antiviral drugs in hospitalized patients with COVID-19 - the DisCoVeRy trial}, url = {https://www.medrxiv.org/content/10.1101/2021.01.08.20248149v1.full.pdf}, volume = {2021}, year = {2021} }
TY - JOUR ID - 1837969 AU - Ader, Florence - Peiffer-Smadja, Nathan - Poissy, Julien - Bouscambert-Duchamp, Maude - Belhadi, Drifa - Diallo, Alpha - Delmas, Christelle - Saillard, Juliette - Dechanet, Aline - Mercier, Noémie - Dupont, Axelle - Alfaiate, Toni - Lescure, François-Xavier - Raffi, François - Goehringer, François - Kimmoun, Antoine - Jaureguiberry, Stéphane - Reignier, Jean - Nseir, Saad - Danion, François - Clere-Jehl, Raphael - Bouiller, Kévin - Navellou, Jean-Christophe - Tolsma, Violaine - Cabie, André - Dubost, Clément - Courjon, Johan - Leroy, Sylvie - Mootien, Joy - Gaci, Rostane - Mourvillier, Bruno - Faure, Emmanuel - Pourcher, Valérie - Gallien, Sébastien - Launay, Odile - Lacombe, Karine - Lanoix, Jean-Philippe - Makinson, Alain - Martin-Blondel, Guillaume - Bouadma, Lila - Botelho-Nevers, Elisabeth - Gagneux-Brunon, Amandine - Epaulard, Olivier - Piroth, Lionel - Wallet, Florent - Richard, Jean-Christophe - Reuter, Jean - Staub, Thérèse - Hites, Maya - Noret, Marion - Andrejak, Claire - Peytavin, Gilles - Lina, Bruno - Costagliola, Dominique - Yazdanpanah, Yazdan - Burdet, Charles - Mentre, France PY - 2021 TI - Antiviral drugs in hospitalized patients with COVID-19 - the DisCoVeRy trial JF - medRxiv 20218149 [Preprint] VL - 2021 IS - 1 SP - 1-31 EP - 1-31 PB - Cold Spring Harbor Laboratory Press SN - 17561833 N1 - EU-RESPONSE KW - COVID-19 KW - SARS-CoV-2 KW - hydroxychloroquine KW - interferon beta-1a KW - lopinavir/ritonavir KW - randomized controlled trial UR - https://www.medrxiv.org/content/10.1101/2021.01.08.20248149v1.full.pdf N2 - Background Lopinavir/ritonavir, lopinavir/ritonavir-interferon (IFN)-β-1a and hydroxychloroquine efficacy for COVID-19 have been evaluated, but detailed evaluation is lacking. Objective To determine the efficacy of lopinavir/ritonavir, lopinavir/ritonavir-IFN-β-1a, hydroxychloroquine or remdesivir for improving the clinical, virological outcomes in COVID-19 inpatients. Design Open-label, randomized, adaptive, controlled trial. ER -
ADER, Florence; Nathan PEIFFER-SMADJA; Julien POISSY; Maude BOUSCAMBERT-DUCHAMP; Drifa BELHADI; Alpha DIALLO; Christelle DELMAS; Juliette SAILLARD; Aline DECHANET; Noémie MERCIER; Axelle DUPONT; Toni ALFAIATE; Fran$\backslash$c cois-Xavier LESCURE; Fran$\backslash$c cois RAFFI; Fran$\backslash$c cois GOEHRINGER; Antoine KIMMOUN; Stéphane JAUREGUIBERRY; Jean REIGNIER; Saad NSEIR; Fran$\backslash$c cois DANION; Raphael CLERE-JEHL; Kévin BOUILLER; Jean-Christophe NAVELLOU; Violaine TOLSMA; André CABIE; Clément DUBOST; Johan COURJON; Sylvie LEROY; Joy MOOTIEN; Rostane GACI; Bruno MOURVILLIER; Emmanuel FAURE; Valérie POURCHER; Sébastien GALLIEN; Odile LAUNAY; Karine LACOMBE; Jean-Philippe LANOIX; Alain MAKINSON; Guillaume MARTIN-BLONDEL; Lila BOUADMA; Elisabeth BOTELHO-NEVERS; Amandine GAGNEUX-BRUNON; Olivier EPAULARD; Lionel PIROTH; Florent WALLET; Jean-Christophe RICHARD; Jean REUTER; Thérèse STAUB; Maya HITES; Marion NORET; Claire ANDREJAK; Gilles PEYTAVIN; Bruno LINA; Dominique COSTAGLIOLA; Yazdan YAZDANPANAH; Charles BURDET a France MENTRE. Antiviral drugs in hospitalized patients with COVID-19 - the DisCoVeRy trial. \textit{medRxiv 20218149 [Preprint]}. London: Cold Spring Harbor Laboratory Press, 2021, roč.~2021, č.~1, s.~1-31. ISSN~1756-1833. Dostupné z: https://dx.doi.org/10.1101/2021.01.08.20248149.