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@article{1838601,
author = {Labajova, N. and Baranova, N. and Jurásek, Miroslav and Vácha, Robert and Loose, M. and Barak, I.},
article_location = {Basel},
article_number = {15},
doi = {http://dx.doi.org/10.3390/ijms22158350},
keywords = {Clostridioides difficile; DivIVA; lipid membrane; cardiolipin; phosphatidylglycerol},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Cardiolipin-Containing Lipid Membranes Attract the Bacterial Cell Division Protein DivIVA},
url = {https://www.mdpi.com/1422-0067/22/15/8350},
volume = {22},
year = {2021}
}
TY - JOUR
ID - 1838601
AU - Labajova, N. - Baranova, N. - Jurásek, Miroslav - Vácha, Robert - Loose, M. - Barak, I.
PY - 2021
TI - Cardiolipin-Containing Lipid Membranes Attract the Bacterial Cell Division Protein DivIVA
JF - International Journal of Molecular Sciences
VL - 22
IS - 15
SP - 8350
EP - 8350
PB - Multidisciplinary Digital Publishing Institute
SN - 14220067
KW - Clostridioides difficile
KW - DivIVA
KW - lipid membrane
KW - cardiolipin
KW - phosphatidylglycerol
UR - https://www.mdpi.com/1422-0067/22/15/8350
N2 - DivIVA is a protein initially identified as a spatial regulator of cell division in the model organism Bacillus subtilis, but its homologues are present in many other Gram-positive bacteria, including Clostridia species. Besides its role as topological regulator of the Min system during bacterial cell division, DivIVA is involved in chromosome segregation during sporulation, genetic competence, and cell wall synthesis. DivIVA localizes to regions of high membrane curvature, such as the cell poles and cell division site, where it recruits distinct binding partners. Previously, it was suggested that negative curvature sensing is the main mechanism by which DivIVA binds to these specific regions. Here, we show that Clostridioides difficile DivIVA binds preferably to membranes containing negatively charged phospholipids, especially cardiolipin. Strikingly, we observed that upon binding, DivIVA modifies the lipid distribution and induces changes to lipid bilayers containing cardiolipin. Our observations indicate that DivIVA might play a more complex and so far unknown active role during the formation of the cell division septal membrane.
ER -
LABAJOVA, N., N. BARANOVA, Miroslav JURÁSEK, Robert VÁCHA, M. LOOSE a I. BARAK. Cardiolipin-Containing Lipid Membranes Attract the Bacterial Cell Division Protein DivIVA. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2021, roč.~22, č.~15, s.~8350-8370. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms22158350.
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