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@article{1842120,
author = {Hrušková, Helena and Voráčová, Ivona and Řemínek, Roman and Foret, František},
article_location = {Weinheim},
article_number = {1},
doi = {http://dx.doi.org/10.1002/jssc.202100621},
keywords = {capillary electrophoresis; drugs; mass spectrometry; metabolome; urine analysis},
language = {eng},
issn = {1615-9306},
journal = {Journal of Separation Science},
title = {Current applications of capillary electrophoresis-mass spectrometry for the analysis of biologically important analytes in urine (2017 to mid-2021): A review},
url = {https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jssc.202100621},
volume = {45},
year = {2022}
}
TY - JOUR
ID - 1842120
AU - Hrušková, Helena - Voráčová, Ivona - Řemínek, Roman - Foret, František
PY - 2022
TI - Current applications of capillary electrophoresis-mass spectrometry for the analysis of biologically important analytes in urine (2017 to mid-2021): A review
JF - Journal of Separation Science
VL - 45
IS - 1
SP - 305-324
EP - 305-324
PB - Wiley
SN - 16159306
KW - capillary electrophoresis
KW - drugs
KW - mass spectrometry
KW - metabolome
KW - urine analysis
UR - https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jssc.202100621
N2 - Capillary electrophoresis coupled online with mass detection is a modern tool for analyzing wide ranges of compounds in complex samples, including urine. Capillary electrophoresis with mass spectrometry allows the separation and identification of various analytes spanning from small ions to high molecular weight protein complexes. Similarly to the much more common liquid chromatography-mass spectrometry techniques, the capillary electrophoresis separation reduces the complexity of the mixture of analytes entering the mass spectrometer resulting in reduced ion suppression and a more straightforward interpretation of the mass spectrometry data. This review summarizes capillary electrophoresis with mass spectrometry studies published between the years 2017 and 2021, aiming at the determination of various compounds excreted in urine. The properties of the urine, including its diagnostical and analytical features and chemical composition, are also discussed including general protocols for the urine sample preparation. The mechanism of the electrophoretic separation and the instrumentation for capillary electrophoresis with mass spectrometry coupling is also included. This review shows the potential of the capillary electrophoresis with mass spectrometry technique for the analyses of different kinds of analytes in a complex biological matrix. The discussed applications are divided into two main groups (capillary electrophoresis with mass spectrometry for the determination of drugs and drugs of abuse in urine and capillary electrophoresis with mass spectrometry for the studies of urinary metabolome).
ER -
HRUŠKOVÁ, Helena, Ivona VORÁČOVÁ, Roman ŘEMÍNEK a František FORET. Current applications of capillary electrophoresis-mass spectrometry for the analysis of biologically important analytes in urine (2017 to mid-2021): A review. \textit{Journal of Separation Science}. Weinheim: Wiley, 2022, roč.~45, č.~1, s.~305-324. ISSN~1615-9306. Dostupné z: https://dx.doi.org/10.1002/jssc.202100621.
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