Extracellular vesicles secreted by model tapeworm Hymenolepis
diminuta: biogenesis, ultrastructure and protein composition

J 2021

Extracellular vesicles secreted by model tapeworm Hymenolepis diminuta: biogenesis, ultrastructure and protein composition

MAZANEC, H., P. KONIK, Z. GARDIAN a R. KUCHTA

Základní údaje

Originální název

Extracellular vesicles secreted by model tapeworm Hymenolepis diminuta: biogenesis, ultrastructure and protein composition

Autoři

MAZANEC, H., P. KONIK, Z. GARDIAN a R. KUCHTA

Vydání

International Journal for Parasitology, Oxford, Elsevier Science Ltd. 2021, 0020-7519

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.330

Kód RIV

RIV/00216224:14740/21:00124443

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.ijpara.2020.09.010

UT WoS

000637359600002

Klíčová slova anglicky

Exosomes; Secretion; Proteins; Size exclusion chromatography; LC?MS; MS; Electron microscopy

Štítky

CF NANO, ne MU, rivok

Změněno: 23. 3. 2022 12:20, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

We provided the first known evidence of the presence and release of extracellular vesicles in adults of important model tapeworm Hymenolepis diminuta. Two different subtypes have been observed on the surface of the worm and among the secretory products confirmed by several microscopical methods. Proteomic analysis revealed the presence of parasite-specific proteins as well as those of the host in purified extracellular vesicles. Among the protein cargo, we identified potential drug targets, vaccine candidates and H. diminuta antigens. Finally, the protein composition further revealed proteins participating in the endosomal complex required for transport-dependent biogenesis pathway. (c)& nbsp;2020 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.

Návaznosti

90127, velká výzkumná infrastruktura

Název: CIISB II

Citovat

MAZANEC, H., P. KONIK, Z. GARDIAN a R. KUCHTA. Extracellular vesicles secreted by model tapeworm Hymenolepis diminuta: biogenesis, ultrastructure and protein composition. International Journal for Parasitology. Oxford: Elsevier Science Ltd., 2021, roč. 51, č. 5, s. 327-332. ISSN 0020-7519. Dostupné z: https://dx.doi.org/10.1016/j.ijpara.2020.09.010.

@article{1842613,
   author = {Mazanec, H. and Konik, P. and Gardian, Z. and Kuchta, R.},
   article_location = {Oxford},
   article_number = {5},
   doi = {http://dx.doi.org/10.1016/j.ijpara.2020.09.010},
   keywords = {Exosomes; Secretion; Proteins; Size exclusion chromatography; LC?MS; MS; Electron microscopy},
   language = {eng},
   issn = {0020-7519},
   journal = {International Journal for Parasitology},
   title = {Extracellular vesicles secreted by model tapeworm Hymenolepis diminuta: biogenesis, ultrastructure and protein composition},
   url = {https://www.sciencedirect.com/science/article/pii/S0020751920303179?via%3Dihub},
   volume = {51},
   year = {2021}
}

TY  - JOUR
ID  - 1842613
AU  - Mazanec, H. - Konik, P. - Gardian, Z. - Kuchta, R.
PY  - 2021
TI  - Extracellular vesicles secreted by model tapeworm Hymenolepis diminuta: biogenesis, ultrastructure and protein composition
JF  - International Journal for Parasitology
VL  - 51
IS  - 5
SP  - 327-332
EP  - 327-332
PB  - Elsevier Science Ltd.
SN  - 00207519
KW  - Exosomes
KW  - Secretion
KW  - Proteins
KW  - Size exclusion chromatography
KW  - LC?MS
KW  - MS
KW  - Electron microscopy
UR  - https://www.sciencedirect.com/science/article/pii/S0020751920303179?via%3Dihub
N2  - We provided the first known evidence of the presence and release of extracellular vesicles in adults of important model tapeworm Hymenolepis diminuta. Two different subtypes have been observed on the surface of the worm and among the secretory products confirmed by several microscopical methods. Proteomic analysis revealed the presence of parasite-specific proteins as well as those of the host in purified extracellular vesicles. Among the protein cargo, we identified potential drug targets, vaccine candidates and H. diminuta antigens. Finally, the protein composition further revealed proteins participating in the endosomal complex required for transport-dependent biogenesis pathway. (c)& nbsp;2020 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.
ER  -

MAZANEC, H., P. KONIK, Z. GARDIAN a R. KUCHTA. Extracellular vesicles secreted by model tapeworm Hymenolepis diminuta: biogenesis, ultrastructure and protein composition. \textit{International Journal for Parasitology}. Oxford: Elsevier Science Ltd., 2021, roč.~51, č.~5, s.~327-332. ISSN~0020-7519. Dostupné z: https://dx.doi.org/10.1016/j.ijpara.2020.09.010.

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