Prenatal stress and its association with amygdala-related
structural covariance patterns in youth

J 2022

Prenatal stress and its association with amygdala-related structural covariance patterns in youth

MAREČKOVÁ, Klára, A. MILES, Z.J. LIAO, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL et. al.

Základní údaje

Originální název

Prenatal stress and its association with amygdala-related structural covariance patterns in youth

Autoři

MAREČKOVÁ, Klára (203 Česká republika, garant, domácí), A. MILES, Z.J. LIAO, Lenka ANDRÝSKOVÁ (203 Česká republika, domácí), Milan BRÁZDIL (203 Česká republika, domácí), T. PAUS a Y.S. NIKOLOVA

Vydání

NeuroImage: Clinical, Oxford, Elsevier BV, 2022, 2213-1582

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.200

Kód RIV

RIV/00216224:14740/22:00125610

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.nicl.2022.102976

UT WoS

000790409500011

Klíčová slova anglicky

Prenatal stress; Structural covariance; Amygdala; Degree centrality; ELSPAC; ALSPAC

Štítky

CF MAFIL, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 10. 2024 09:58, Ing. Jana Kuchtová

Anotace

V originále

Background: Prenatal stress influences brain development and mood disorder vulnerability. Brain structural covariance network (SCN) properties based on inter-regional volumetric correlations may reflect developmentally-mediated shared plasticity among regions. Childhood trauma is associated with amygdalacentric SCN reorganization patterns, however, the impact of prenatal stress on SCN properties remains unknown. Methods: The study included participants from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with archival prenatal stress data and structural MRI acquired in young adulthood (age 23-24). SCNs were constructed based on Freesurfer-extracted volumes of 7 subcortical and 34 cortical regions. We compared amygdala degree centrality, a measure of hubness, between those exposed to high vs. low (median split) prenatal stress, defined by maternal reports of stressful life events during the first (n = 93, 57% female) and second (n = 125, 54% female) half of pregnancy. Group differences were tested across network density thresholds (5-40%) using 10,000 permutations, with sex and intracranial volume as covariates, followed by sex-specific analyses. Finally, we sought to replicate our results in an independent all-male sample (n = 450, age 18-20) from the Avon Longitudinal Study of Parents and Children (ALSPAC). Results: The high-stress during the first half of pregnancy ELSPAC group showed lower amygdala degree particularly in men, who demonstrated this difference at 10 consecutive thresholds, with no significant differences in global network properties. At the lowest significant density threshold, amygdala volume was positively correlated with hippocampus, putamen, rostral anterior and posterior cingulate, transverse temporal, and pericalcarine cortex in the low-stress (p(FDR) < 0.027), but not the high-stress (p(FDR) > 0.882) group. Although amygdala degree was nominally lower across thresholds in the high-stress ALSPAC group, these results were not significant. Conclusion: Unlike childhood trauma, prenatal stress may shift SCN towards a less amygdala-centric SCN pattern, particularly in men. These findings did not replicate in an all-male ALSPAC sample, possibly due to the sample's younger age and lower prenatal stress exposure.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NU20J-04-00022, projekt VaV

Název: Zdravé stárnutí mozku: Celoživotní perspektiva

Investor: Ministerstvo zdravotnictví ČR, Zdravé stárnutí mozku: Celoživotní perspektiva, Podprogram 2 - juniorský - výzkumníci do 35 let

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

MAREČKOVÁ, Klára, A. MILES, Z.J. LIAO, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, T. PAUS a Y.S. NIKOLOVA. Prenatal stress and its association with amygdala-related structural covariance patterns in youth. NeuroImage: Clinical. Oxford: Elsevier BV, 2022, roč. 34, May 2022, s. 1-11. ISSN 2213-1582. Dostupné z: https://dx.doi.org/10.1016/j.nicl.2022.102976.

@article{1844922,
   author = {Marečková, Klára and Miles, A. and Liao, Z.J. and Andrýsková, Lenka and Brázdil, Milan and Paus, T. and Nikolova, Y.S.},
   article_location = {Oxford},
   article_number = {May 2022},
   doi = {http://dx.doi.org/10.1016/j.nicl.2022.102976},
   keywords = {Prenatal stress; Structural covariance; Amygdala; Degree centrality; ELSPAC; ALSPAC},
   language = {eng},
   issn = {2213-1582},
   journal = {NeuroImage: Clinical},
   title = {Prenatal stress and its association with amygdala-related structural covariance patterns in youth},
   url = {https://www.sciencedirect.com/science/article/pii/S2213158222000419},
   volume = {34},
   year = {2022}
}

TY  - JOUR
ID  - 1844922
AU  - Marečková, Klára - Miles, A. - Liao, Z.J. - Andrýsková, Lenka - Brázdil, Milan - Paus, T. - Nikolova, Y.S.
PY  - 2022
TI  - Prenatal stress and its association with amygdala-related structural covariance patterns in youth
JF  - NeuroImage: Clinical
VL  - 34
IS  - May 2022
SP  - 1-11
EP  - 1-11
PB  - Elsevier BV
SN  - 22131582
KW  - Prenatal stress
KW  - Structural covariance
KW  - Amygdala
KW  - Degree centrality
KW  - ELSPAC
KW  - ALSPAC
UR  - https://www.sciencedirect.com/science/article/pii/S2213158222000419
N2  - Background: Prenatal stress influences brain development and mood disorder vulnerability. Brain structural covariance network (SCN) properties based on inter-regional volumetric correlations may reflect developmentally-mediated shared plasticity among regions. Childhood trauma is associated with amygdalacentric SCN reorganization patterns, however, the impact of prenatal stress on SCN properties remains unknown. Methods: The study included participants from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with archival prenatal stress data and structural MRI acquired in young adulthood (age 23-24). SCNs were constructed based on Freesurfer-extracted volumes of 7 subcortical and 34 cortical regions. We compared amygdala degree centrality, a measure of hubness, between those exposed to high vs. low (median split) prenatal stress, defined by maternal reports of stressful life events during the first (n = 93, 57% female) and second (n = 125, 54% female) half of pregnancy. Group differences were tested across network density thresholds (5-40%) using 10,000 permutations, with sex and intracranial volume as covariates, followed by sex-specific analyses. Finally, we sought to replicate our results in an independent all-male sample (n = 450, age 18-20) from the Avon Longitudinal Study of Parents and Children (ALSPAC). Results: The high-stress during the first half of pregnancy ELSPAC group showed lower amygdala degree particularly in men, who demonstrated this difference at 10 consecutive thresholds, with no significant differences in global network properties. At the lowest significant density threshold, amygdala volume was positively correlated with hippocampus, putamen, rostral anterior and posterior cingulate, transverse temporal, and pericalcarine cortex in the low-stress (p(FDR) < 0.027), but not the high-stress (p(FDR) > 0.882) group. Although amygdala degree was nominally lower across thresholds in the high-stress ALSPAC group, these results were not significant. Conclusion: Unlike childhood trauma, prenatal stress may shift SCN towards a less amygdala-centric SCN pattern, particularly in men. These findings did not replicate in an all-male ALSPAC sample, possibly due to the sample's younger age and lower prenatal stress exposure.
ER  -

MAREČKOVÁ, Klára, A. MILES, Z.J. LIAO, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, T. PAUS a Y.S. NIKOLOVA. Prenatal stress and its association with amygdala-related structural covariance patterns in youth. \textit{NeuroImage: Clinical}. Oxford: Elsevier BV, 2022, roč.~34, May 2022, s.~1-11. ISSN~2213-1582. Dostupné z: https://dx.doi.org/10.1016/j.nicl.2022.102976.

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