Association of the angiotensin I converting enzyme (ACE) gene
polymorphisms with recurrent aphthous stomatitis in the Czech
population: case-control study

J 2022

Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study

BARTÁKOVÁ, Julie, Tereza DEISSOVÁ, Simona SLEZÁKOVÁ, Jirina BARTOVA, Jitka PETANOVA et. al.

Základní údaje

Originální název

Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study

Autoři

BARTÁKOVÁ, Julie (203 Česká republika, domácí), Tereza DEISSOVÁ (203 Česká republika, domácí), Simona SLEZÁKOVÁ (203 Česká republika, domácí), Jirina BARTOVA (203 Česká republika), Jitka PETANOVA (203 Česká republika), Pavel KUKLÍNEK (203 Česká republika, domácí), Antonín FASSMANN (203 Česká republika, domácí), Petra BOŘILOVÁ LINHARTOVÁ (203 Česká republika, domácí), Ladislav DUŠEK (203 Česká republika, domácí) a Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika, garant, domácí)

Vydání

BMC Oral Health, London, BMC, 2022, 1472-6831

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.900

Kód RIV

RIV/00216224:14110/22:00125641

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1186/s12903-022-02115-3

UT WoS

000770760100002

Klíčová slova anglicky

Recurrent aphthous stomatitis; Angiotensin I converting enzyme; Polymorphism; Haplotype; Sex difference

Štítky

14110130, 14110518, 14119612, 14119613, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 3. 2023 13:45, Mgr. Tereza Miškechová

Anotace

V originále

Background Recurrent aphthous stomatitis (RAS) is multifactorial disease with unclear etiopathogenesis. The aim of this study was to determine distribution of the angiotensin I converting enzyme (ACE) gene polymorphisms and their influence on RAS susceptibility in Czech population. Methods The study included 230 subjects (143 healthy controls and 87 patients with RAS) with anamnestic, clinical and laboratory data. Five ACE gene polymorphisms (rs4291/rs4305/rs4311/rs4331/rs1799752 = ACE I/D) were determined by TaqMan technique. Results The allele and genotype distributions of the studied ACE I/D polymorphisms were not significantly different between subjects with/without RAS (P-corr > 0.05). However, carriers of II genotype were less frequent in the RAS group (OR = 0.48, 95% CI = 0.21-1.12, P = 0.059). Stratified analysis by sex demonstrated lower frequency of II genotype in women (OR = 0.33, 95% CI = 0.09-1.17, P < 0.035, P-corr > 0.05, respectively) than in men with RAS (P > 0.05). Moreover, the frequency of AGTGD haplotype was significantly increased in RAS patients (OR = 13.74, 95% CI = 1.70-110.79, P = 0.0012, P-corr < 0.05). In subanalysis, TGD haplotype was significantly more frequent in RAS patients (P < 0.00001) and CGI haplotype was less frequent in RAS patients (P < 0.01), especially in women (P = 0.016, P-corr > 0.05). Conclusions Our study indicates that while the AGTGD and TGD haplotypes are associated with increased risk of RAS development, CGI haplotype might be one of protective factors against RAS susceptibility in Czech population.

Návaznosti

MUNI/A/1445/2021, interní kód MU

Název: Nemoci dutiny ústní – výzkum jejich etiopatogeneze, diagnostiky a léčebných přístupů

Investor: Masarykova univerzita, Nemoci dutiny ústní – výzkum jejich etiopatogeneze, diagnostiky a léčebných přístupů

Citovat

BARTÁKOVÁ, Julie, Tereza DEISSOVÁ, Simona SLEZÁKOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLÍNEK, Antonín FASSMANN, Petra BOŘILOVÁ LINHARTOVÁ, Ladislav DUŠEK a Lydie IZAKOVIČOVÁ HOLLÁ. Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study. BMC Oral Health. London: BMC, 2022, roč. 22, č. 1, s. 1-9. ISSN 1472-6831. Dostupné z: https://dx.doi.org/10.1186/s12903-022-02115-3.

@article{1846403,
   author = {Bartáková, Julie and Deissová, Tereza and Slezáková, Simona and Bartova, Jirina and Petanova, Jitka and Kuklínek, Pavel and Fassmann, Antonín and Bořilová Linhartová, Petra and Dušek, Ladislav and Izakovičová Hollá, Lydie},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s12903-022-02115-3},
   keywords = {Recurrent aphthous stomatitis; Angiotensin I converting enzyme; Polymorphism; Haplotype; Sex difference},
   language = {eng},
   issn = {1472-6831},
   journal = {BMC Oral Health},
   title = {Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study},
   url = {https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-022-02115-3},
   volume = {22},
   year = {2022}
}

TY  - JOUR
ID  - 1846403
AU  - Bartáková, Julie - Deissová, Tereza - Slezáková, Simona - Bartova, Jirina - Petanova, Jitka - Kuklínek, Pavel - Fassmann, Antonín - Bořilová Linhartová, Petra - Dušek, Ladislav - Izakovičová Hollá, Lydie
PY  - 2022
TI  - Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study
JF  - BMC Oral Health
VL  - 22
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - BMC
SN  - 14726831
KW  - Recurrent aphthous stomatitis
KW  - Angiotensin I converting enzyme
KW  - Polymorphism
KW  - Haplotype
KW  - Sex difference
UR  - https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-022-02115-3
N2  - Background Recurrent aphthous stomatitis (RAS) is multifactorial disease with unclear etiopathogenesis. The aim of this study was to determine distribution of the angiotensin I converting enzyme (ACE) gene polymorphisms and their influence on RAS susceptibility in Czech population. Methods The study included 230 subjects (143 healthy controls and 87 patients with RAS) with anamnestic, clinical and laboratory data. Five ACE gene polymorphisms (rs4291/rs4305/rs4311/rs4331/rs1799752 = ACE I/D) were determined by TaqMan technique. Results The allele and genotype distributions of the studied ACE I/D polymorphisms were not significantly different between subjects with/without RAS (P-corr > 0.05). However, carriers of II genotype were less frequent in the RAS group (OR = 0.48, 95% CI = 0.21-1.12, P = 0.059). Stratified analysis by sex demonstrated lower frequency of II genotype in women (OR = 0.33, 95% CI = 0.09-1.17, P < 0.035, P-corr > 0.05, respectively) than in men with RAS (P > 0.05). Moreover, the frequency of AGTGD haplotype was significantly increased in RAS patients (OR = 13.74, 95% CI = 1.70-110.79, P = 0.0012, P-corr < 0.05). In subanalysis, TGD haplotype was significantly more frequent in RAS patients (P < 0.00001) and CGI haplotype was less frequent in RAS patients (P < 0.01), especially in women (P = 0.016, P-corr > 0.05). Conclusions Our study indicates that while the AGTGD and TGD haplotypes are associated with increased risk of RAS development, CGI haplotype might be one of protective factors against RAS susceptibility in Czech population.
ER  -

BARTÁKOVÁ, Julie, Tereza DEISSOVÁ, Simona SLEZÁKOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLÍNEK, Antonín FASSMANN, Petra BOŘILOVÁ LINHARTOVÁ, Ladislav DUŠEK a Lydie IZAKOVIČOVÁ HOLLÁ. Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study. \textit{BMC Oral Health}. London: BMC, 2022, roč.~22, č.~1, s.~1-9. ISSN~1472-6831. Dostupné z: https://dx.doi.org/10.1186/s12903-022-02115-3.

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