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@article{1847088,
author = {Milota, Tomas and Sobotkova, Marta and Smetanova, Jitka and Bloomfield, Marketa and Vydlakova, Jana and Chovancová, Zita and Litzman, Jiří and Hakl, Roman and Novak, Jiri and Malkusova, Ivana and Hanzlikova, Jana and Jilek, Dalibor and Hutyrova, Beata and Novak, Vitezslav and Krcmova, Irena and Sediva, Anna and Kralickova, Pavlina},
article_location = {Laussane},
article_number = {February 2022},
doi = {http://dx.doi.org/10.3389/fimmu.2022.835770},
keywords = {COVID-19; SARS-CoV-2; hospital admission; inborn errors of immunity; mortality; risk factors},
language = {eng},
issn = {1664-3224},
journal = {Frontiers in Immunology},
title = {Risk Factors for Severe COVID-19 and Hospital Admission in Patients With Inborn Errors of Immunity-Results From a Multicenter Nationwide Study},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2022.835770/full},
volume = {13},
year = {2022}
}
TY - JOUR
ID - 1847088
AU - Milota, Tomas - Sobotkova, Marta - Smetanova, Jitka - Bloomfield, Marketa - Vydlakova, Jana - Chovancová, Zita - Litzman, Jiří - Hakl, Roman - Novak, Jiri - Malkusova, Ivana - Hanzlikova, Jana - Jilek, Dalibor - Hutyrova, Beata - Novak, Vitezslav - Krcmova, Irena - Sediva, Anna - Kralickova, Pavlina
PY - 2022
TI - Risk Factors for Severe COVID-19 and Hospital Admission in Patients With Inborn Errors of Immunity-Results From a Multicenter Nationwide Study
JF - Frontiers in Immunology
VL - 13
IS - February 2022
SP - 1-8
EP - 1-8
PB - Frontiers
SN - 16643224
KW - COVID-19
KW - SARS-CoV-2
KW - hospital admission
KW - inborn errors of immunity
KW - mortality
KW - risk factors
UR - https://www.frontiersin.org/articles/10.3389/fimmu.2022.835770/full
N2 - Despite the progress in the understanding how COVID-19 infection may impact immunocompromised patients, the data on inborn errors of immunity (IEI) remain limited and ambiguous. Therefore, we examined the risk of severe infection course and hospital admission in a large cohort of patients with IEI. In this multicenter nationwide retrospective survey-based trial, the demographic, clinical, and laboratory data were collected by investigating physicians from 8 national referral centers for the diagnosis and treatment of IEI using a COVID-19-IEI clinical questionnaire. In total, 81 patients with IEI (including 16 with hereditary angioedema, HAE) and confirmed SARS-CoV-2 infection were enrolled, and were found to have a 2.3-times increased (95%CI: 1.44-3.53) risk ratio for hospital admission and a higher mortality ratio (2.4% vs. 1.7% in the general population). COVID-19 severity was associated with the presence of clinically relevant comorbidities, lymphopenia, and hypogammaglobulinemia, but not with age or BMI. No individuals with HAE developed severe disease, despite a hypothesized increased risk due to perturbed bradykinin metabolism. We also demonstrated a high seroconversion rate in antibody-deficient patients and the safety of anti-spike SARS CoV-2 monoclonal antibodies and convalescent plasma. Thus, IEI except for HAE, represent significant risk factors for a severe COVID-19. Therefore, apart from general risk factors, immune system dysregulation may also be involved in the poor outcomes of COVID-19. Despite the study limitations, our results support the findings from previously published trials.
ER -
MILOTA, Tomas, Marta SOBOTKOVA, Jitka SMETANOVA, Marketa BLOOMFIELD, Jana VYDLAKOVA, Zita CHOVANCOVÁ, Jiří LITZMAN, Roman HAKL, Jiri NOVAK, Ivana MALKUSOVA, Jana HANZLIKOVA, Dalibor JILEK, Beata HUTYROVA, Vitezslav NOVAK, Irena KRCMOVA, Anna SEDIVA and Pavlina KRALICKOVA. Risk Factors for Severe COVID-19 and Hospital Admission in Patients With Inborn Errors of Immunity-Results From a Multicenter Nationwide Study. \textit{Frontiers in Immunology}. Laussane: Frontiers, 2022, vol.~13, February 2022, p.~1-8. ISSN~1664-3224. Available from: https://dx.doi.org/10.3389/fimmu.2022.835770.
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