Bridging structural and functional biomarkers in functional
movement disorder using network mapping

J 2022

Bridging structural and functional biomarkers in functional movement disorder using network mapping

SOJKA, Petr, Matěj SLOVÁK, Gabriela VĚCHETOVÁ, Robert JECH, David PEREZ et. al.

Základní údaje

Originální název

Bridging structural and functional biomarkers in functional movement disorder using network mapping

Autoři

SOJKA, Petr (203 Česká republika, garant, domácí), Matěj SLOVÁK (203 Česká republika), Gabriela VĚCHETOVÁ (203 Česká republika), Robert JECH (203 Česká republika), David PEREZ a Tereza SERRANOVÁ (203 Česká republika)

Vydání

Brain and Behavior, Hoboken, John Wiley and Sons Inc. 2022, 2162-3279

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.100

Kód RIV

RIV/00216224:14110/22:00125676

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/brb3.2576

UT WoS

000782842400001

Klíčová slova anglicky

structural and functional biomarkers; functional movement disorder; network mapping

Štítky

14110222, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 1. 2023 13:19, Mgr. Tereza Miškechová

Anotace

V originále

Background There are gaps in our neurobiological understanding of functional movement disorder (FMD). Objectives We investigated gray matter volumetric profiles in FMD, and related findings to resting-state functional connectivity (rsFC) profiles using Human Connectome Project data. Methods Volumetric differences between 53 FMD patients and 50 controls were examined, as well as relationships between individual differences in FMD symptom severity and volumetric profiles. Atrophy network mapping was also used to probe whether FMD-related structural alterations preferentially impacted brain areas with dense rsFC. Results Compared to controls without neurological comorbidities (albeit with mild depression and anxiety as a group), the FMD cohort did not show any volumetric differences. Across patients with FMD, individual differences in symptom severity negatively correlated with right supramarginal and bilateral superior temporal gyri volumes. These findings remained significant adjusting for FMD subtype or antidepressant use, but did not remain statistically significant adjusting for depression and anxiety scores. Symptom severity-related structural alterations mapped onto regions with dense rsFC-identifying several disease epicenters in default mode, ventral attention, and salience networks. Conclusions This study supports that FMD is a multinetwork disorder with an important role for the temporoparietal junction and its related connectivity in the pathophysiology of this condition. More research is needed to explore the intersection of functional neurological symptoms and mood.

Citovat

SOJKA, Petr, Matěj SLOVÁK, Gabriela VĚCHETOVÁ, Robert JECH, David PEREZ a Tereza SERRANOVÁ. Bridging structural and functional biomarkers in functional movement disorder using network mapping. Brain and Behavior. Hoboken: John Wiley and Sons Inc., 2022, roč. 12, č. 5, s. 1-5. ISSN 2162-3279. Dostupné z: https://dx.doi.org/10.1002/brb3.2576.

@article{1847698,
   author = {Sojka, Petr and Slovák, Matěj and Věchetová, Gabriela and Jech, Robert and Perez, David and Serranová, Tereza},
   article_location = {Hoboken},
   article_number = {5},
   doi = {http://dx.doi.org/10.1002/brb3.2576},
   keywords = {structural and functional biomarkers; functional movement disorder; network mapping},
   language = {eng},
   issn = {2162-3279},
   journal = {Brain and Behavior},
   title = {Bridging structural and functional biomarkers in functional movement disorder using network mapping},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/brb3.2576},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 1847698
AU  - Sojka, Petr - Slovák, Matěj - Věchetová, Gabriela - Jech, Robert - Perez, David - Serranová, Tereza
PY  - 2022
TI  - Bridging structural and functional biomarkers in functional movement disorder using network mapping
JF  - Brain and Behavior
VL  - 12
IS  - 5
SP  - 1-5
EP  - 1-5
PB  - John Wiley and Sons Inc.
SN  - 21623279
KW  - structural and functional biomarkers
KW  - functional movement disorder
KW  - network mapping
UR  - https://onlinelibrary.wiley.com/doi/10.1002/brb3.2576
N2  - Background There are gaps in our neurobiological understanding of functional movement disorder (FMD). Objectives We investigated gray matter volumetric profiles in FMD, and related findings to resting-state functional connectivity (rsFC) profiles using Human Connectome Project data. Methods Volumetric differences between 53 FMD patients and 50 controls were examined, as well as relationships between individual differences in FMD symptom severity and volumetric profiles. Atrophy network mapping was also used to probe whether FMD-related structural alterations preferentially impacted brain areas with dense rsFC. Results Compared to controls without neurological comorbidities (albeit with mild depression and anxiety as a group), the FMD cohort did not show any volumetric differences. Across patients with FMD, individual differences in symptom severity negatively correlated with right supramarginal and bilateral superior temporal gyri volumes. These findings remained significant adjusting for FMD subtype or antidepressant use, but did not remain statistically significant adjusting for depression and anxiety scores. Symptom severity-related structural alterations mapped onto regions with dense rsFC-identifying several disease epicenters in default mode, ventral attention, and salience networks. Conclusions This study supports that FMD is a multinetwork disorder with an important role for the temporoparietal junction and its related connectivity in the pathophysiology of this condition. More research is needed to explore the intersection of functional neurological symptoms and mood.
ER  -

SOJKA, Petr, Matěj SLOVÁK, Gabriela VĚCHETOVÁ, Robert JECH, David PEREZ a Tereza SERRANOVÁ. Bridging structural and functional biomarkers in functional movement disorder using network mapping. \textit{Brain and Behavior}. Hoboken: John Wiley and Sons Inc., 2022, roč.~12, č.~5, s.~1-5. ISSN~2162-3279. Dostupné z: https://dx.doi.org/10.1002/brb3.2576.

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