J 2022

Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant

OPATŘIL, Lukáš, Roman PANOVSKÝ, Mary MOJICA-PISCIOTTI, Jan MÁCHAL, Jan KREJČÍ et. al.

Základní údaje

Originální název

Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant

Autoři

OPATŘIL, Lukáš (203 Česká republika, domácí), Roman PANOVSKÝ (203 Česká republika, garant, domácí), Mary MOJICA-PISCIOTTI, Jan MÁCHAL (203 Česká republika, domácí), Jan KREJČÍ (203 Česká republika, domácí), Tomáš HOLEČEK (203 Česká republika), Lucia MASÁROVÁ (703 Slovensko, domácí), Věra FEITOVÁ (203 Česká republika), Július GODAVA (703 Slovensko), Vladimír KINCL (203 Česká republika, domácí), Tomáš KEPÁK (203 Česká republika), Gabriela ZÁVODNÁ (203 Česká republika, domácí) a Lenka ŠPINAROVÁ (203 Česká republika, domácí)

Vydání

Scientific Reports, Berlin, Nature, 2022, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 4.600

Kód RIV

RIV/00216224:14110/22:00125708

Organizační jednotka

Lékařská fakulta

DOI

UT WoS

000782202600081

Klíčová slova anglicky

Stress pulmonary circulation; cardiovascular magnetic resonance; heart transplant

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 19. 7. 2022 13:08, Mgr. Tereza Miškechová

Anotace

V originále

Rest pulmonary circulation parameters such as pulmonary transit time (PTT), heart rate corrected PTT (PTTc) and pulmonary transit beats (PTB) can be evaluated using several methods, including the first-pass perfusion from cardiovascular magnetic resonance. As previously published, up to 58% of patients after HTx have diastolic dysfunction detectable only in stress conditions. By using adenosine stress perfusion images, stress analogues of the mentioned parameters can be assessed. By dividing stress to rest biomarkers, potential new ratio parameters (PTT ratio and PTTc ratio) can be obtained. The objectives were to (1) provide more evidence about stress pulmonary circulation biomarkers, (2) present stress to rest ratio parameters, and (3) assess these biomarkers in patients with presumed diastolic dysfunction after heart transplant (HTx) and in childhood cancer survivors (CCS) without any signs of diastolic dysfunction. In this retrospective study, 48 patients after HTx, divided into subgroups based on echocardiographic signs of diastolic dysfunction (41 without, 7 with) and 39 CCS were enrolled. PTT was defined as the difference between the onset time of the signal intensity increase in the left and the right ventricle. PTT in rest conditions were without significant differences when comparing the CCS and HTx subgroup without diastolic dysfunction (4.96 ± 0.93 s vs. 5.51 ± 1.14 s, p = 0.063) or with diastolic dysfunction (4.96 ± 0.93 s vs. 6.04 ± 1.13 s, p = 0.13). However, in stress conditions, both PTT and PTTc were significantly lower in the CCS group than in the HTx subgroups, (PTT: 3.76 ± 0.78 s vs. 4.82 ± 1.03 s, p < 0.001; 5.52 ± 1.56 s, p = 0.002). PTT ratio and PTTc ratio were below 1 in all groups. In conclusion, stress pulmonary circulation parameters obtained from CMR showed prolonged PTT and PTTc in HTx groups compared to CCS, which corresponds with the presumption of underlying diastolic dysfunction. The ratio parameters were less than 1.