FOŘTOVÁ, Andrea, Václav HÖNIG, Martin PALUS, Jiří SALÁT, Martina PÝCHOVÁ, Lenka KRBKOVÁ, Tereza VYHLÍDALOVÁ, Michal F. KŘÍHA, Aleš CHRDLE a Daniel RŮŽEK. Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis. Journal of General Virology. Microbiology Society, 2022, roč. 103, č. 5, s. 1-7. ISSN 0022-1317. Dostupné z: https://dx.doi.org/10.1099/jgv.0.001743. |
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@article{1851597, author = {Fořtová, Andrea and Hönig, Václav and Palus, Martin and Salát, Jiří and Pýchová, Martina and Krbková, Lenka and Vyhlídalová, Tereza and Kříha, Michal F. and Chrdle, Aleš and Růžek, Daniel}, article_number = {5}, doi = {http://dx.doi.org/10.1099/jgv.0.001743}, keywords = {biomarker; brain injury; flavivirus; neurofilament; tick-borne encephalitis}, language = {eng}, issn = {0022-1317}, journal = {Journal of General Virology}, title = {Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis.}, url = {https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001743}, volume = {103}, year = {2022} }
TY - JOUR ID - 1851597 AU - Fořtová, Andrea - Hönig, Václav - Palus, Martin - Salát, Jiří - Pýchová, Martina - Krbková, Lenka - Vyhlídalová, Tereza - Kříha, Michal F. - Chrdle, Aleš - Růžek, Daniel PY - 2022 TI - Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis. JF - Journal of General Virology VL - 103 IS - 5 SP - 1-7 EP - 1-7 PB - Microbiology Society SN - 00221317 KW - biomarker KW - brain injury KW - flavivirus KW - neurofilament KW - tick-borne encephalitis UR - https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001743 N2 - Extensive axonal and neuronal loss is the main cause of severe manifestations and poor outcomes in tick-borne encephalitis (TBE). Phosphorylated neurofilament heavy subunit (pNF-H) is an essential component of axons, and its detection in cerebrospinal fluid (CSF) or serum can indicate the degree of neuroaxonal damage. We examined the use of pNF-H as a biomarker of neuroaxonal injury in TBE. In 89 patients with acute TBE, we measured CSF levels of pNF-H and 3 other markers of brain injury (glial fibrillary acidic protein, S100B and ubiquitin C-terminal hydrolase L1) and compared the results to those for patients with meningitis of other aetiology and controls. Serum pNF-H levels were measured in 80 patients and compared with findings for 90 healthy blood donors. TBE patients had significantly (P<0.001) higher CSF pNF-H levels than controls as early as hospital admission. Serum pNF-H concentrations were significantly higher in samples from TBE patients collected at hospital discharge (P<0.0001) than in controls. TBE patients with the highest peak values of serum pNF-H, exceeding 10 000 pg ml−1, had a very severe disease course, with coma or tetraplegia. Patients requiring intensive care had significantly higher serum pNF-H levels than other TBE patients (P<0.01). Elevated serum pNF-H values were also observed in patients with incomplete recovery (P<0.05). Peak serum pNF-H levels correlated positively with the duration of hospitalization (P=0.005). Measurement of pNF-H levels in TBE patients might be useful for assessing disease severity and determining prognosis. ER -
FOŘTOVÁ, Andrea, Václav HÖNIG, Martin PALUS, Jiří SALÁT, Martina PÝCHOVÁ, Lenka KRBKOVÁ, Tereza VYHLÍDALOVÁ, Michal F. KŘÍHA, Aleš CHRDLE a Daniel RŮŽEK. Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis. \textit{Journal of General Virology}. Microbiology Society, 2022, roč.~103, č.~5, s.~1-7. ISSN~0022-1317. Dostupné z: https://dx.doi.org/10.1099/jgv.0.001743.
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