| FOŘTOVÁ, Andrea, Václav HÖNIG, Martin PALUS, Jiří SALÁT, Martina PÝCHOVÁ, Lenka KRBKOVÁ, Tereza VYHLÍDALOVÁ, Michal F. KŘÍHA, Aleš CHRDLE and Daniel RŮŽEK. Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis. Journal of General Virology. Microbiology Society, 2022, vol. 103, No 5, p. 1-7. ISSN 0022-1317. Available from: https://dx.doi.org/10.1099/jgv.0.001743. |
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@article{1851597,
author = {Fořtová, Andrea and Hönig, Václav and Palus, Martin and Salát, Jiří and Pýchová, Martina and Krbková, Lenka and Vyhlídalová, Tereza and Kříha, Michal F. and Chrdle, Aleš and Růžek, Daniel},
article_number = {5},
doi = {http://dx.doi.org/10.1099/jgv.0.001743},
keywords = {biomarker; brain injury; flavivirus; neurofilament; tick-borne encephalitis},
language = {eng},
issn = {0022-1317},
journal = {Journal of General Virology},
title = {Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis.},
url = {https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001743},
volume = {103},
year = {2022}
}
TY - JOUR
ID - 1851597
AU - Fořtová, Andrea - Hönig, Václav - Palus, Martin - Salát, Jiří - Pýchová, Martina - Krbková, Lenka - Vyhlídalová, Tereza - Kříha, Michal F. - Chrdle, Aleš - Růžek, Daniel
PY - 2022
TI - Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis.
JF - Journal of General Virology
VL - 103
IS - 5
SP - 1-7
EP - 1-7
PB - Microbiology Society
SN - 00221317
KW - biomarker
KW - brain injury
KW - flavivirus
KW - neurofilament
KW - tick-borne encephalitis
UR - https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001743
N2 - Extensive axonal and neuronal loss is the main cause of severe manifestations and poor outcomes in tick-borne encephalitis (TBE). Phosphorylated neurofilament heavy subunit (pNF-H) is an essential component of axons, and its detection in cerebrospinal fluid (CSF) or serum can indicate the degree of neuroaxonal damage. We examined the use of pNF-H as a biomarker of neuroaxonal injury in TBE. In 89 patients with acute TBE, we measured CSF levels of pNF-H and 3 other markers of brain injury (glial fibrillary acidic protein, S100B and ubiquitin C-terminal hydrolase L1) and compared the results to those for patients with meningitis of other aetiology and controls. Serum pNF-H levels were measured in 80 patients and compared with findings for 90 healthy blood donors. TBE patients had significantly (P<0.001) higher CSF pNF-H levels than controls as early as hospital admission. Serum pNF-H concentrations were significantly higher in samples from TBE patients collected at hospital discharge (P<0.0001) than in controls. TBE patients with the highest peak values of serum pNF-H, exceeding 10 000 pg ml−1, had a very severe disease course, with coma or tetraplegia. Patients requiring intensive care had significantly higher serum pNF-H levels than other TBE patients (P<0.01). Elevated serum pNF-H values were also observed in patients with incomplete recovery (P<0.05). Peak serum pNF-H levels correlated positively with the duration of hospitalization (P=0.005). Measurement of pNF-H levels in TBE patients might be useful for assessing disease severity and determining prognosis.
ER -
FOŘTOVÁ, Andrea, Václav HÖNIG, Martin PALUS, Jiří SALÁT, Martina PÝCHOVÁ, Lenka KRBKOVÁ, Tereza VYHLÍDALOVÁ, Michal F. KŘÍHA, Aleš CHRDLE and Daniel RŮŽEK. Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis. \textit{Journal of General Virology}. Microbiology Society, 2022, vol.~103, No~5, p.~1-7. ISSN~0022-1317. Available from: https://dx.doi.org/10.1099/jgv.0.001743.
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