J 2017

Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

BERNATSKY, Sasha, Hector A Velasque GARCI, John J SPINELL, Patric GAFFNE, Karin E SMEDB et. al.

Basic information

Original name

Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Authors

BERNATSKY, Sasha (guarantor), Hector A Velasque GARCI, John J SPINELL, Patric GAFFNE, Karin E SMEDB, Rosalin RAMSEY-GOLDMA, Sophia S WAN, Hans-Olo ADAM, Demetriu ALBANE, Emanuel ANGELUCC, Stephen M ANSEL, Yan W ASMAN, Nikolau BECKE, Yoland BENAVENT, Sonja I BERND, Kimberly A BERTRAN, Brenda M BIRMAN, Heine BOEIN, Paol BOFFETT, Paige M BRACC, Pau BRENNA, Angela R BROOKS-WILSO, James R CERHA, Stephen J CHANOC, Jacquelin CLAVE, Luci COND, Karen H COTENBADE, David G CO, Wend COZE, Simo CROUC, Roo Anneclaire J DE, Sanjos Silvi DE, Loll Simonett DI, W Rya DIVE, Ahme DOGA, Lenka FORETOVÁ (203 Czech Republic, belonging to the institution), Herv GHESQUIERE, Graham G GILE, Beng GLIMELIU, Thomas M HABERMAN, Corinn HAIOU, Patrici HARTG, Henri HJALGRI, Theodore R HOLFOR, Elizabeth A HOLL, Rebecca D JACKSO, Rudolp KAAK, Eleano KAN, Rachel S KELL, Robert J KLEI, Pete KRAF, Ann KRICKE, Qin LA, Lawrenc CHARLE, Mar LIEBO, Trac LIGHTFOO, Brian K LIN, Mar MAYNADI, Jame MCKA, Mad MELBY, Thierry J MOLIN, Alai MONNEREA, Lindsay M MORTO, Alexandr NIETER, Kari E NORT, Anne J NOVA, Kennet OFFI, Mark P PURDU, Marc RAI, Jacque RIB, Ev ROMA, Nathanie ROTHMA, Gille SALLE, Gianluc SEVER, Richard K SEVERSO, Christine F SKIBOL, Susan L SLAGE, Ale SMIT, Martyn T SMIT, Melissa C SOUTHE, Anthon STAINE, Lauren R TERA, Carrie A THOMPSO, Herv TILL, Lesley F TINKE, Ann TJONNELAN, Jenn TURNE, Claire M VAJDI, Roel C H VERMEULE, Josep VIJA, Paol VINEI, Jarm VIRTAM, Zhaomin WAN, Stephani WEINSTEI, Thomas E WITZI, Andre ZELENET, Ann ZELENIUCH-JACQUOTT, Yawe ZHAN, Tongzhan ZHEN, Mariagrazi ZUCC and Ann E CLARK

Edition

LUPUS SCIENCE & MEDICINE, London, BMJ, 2017, 2053-8790

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

RIV identification code

RIV/00216224:14110/17:00124647

Organization unit

Faculty of Medicine

UT WoS

000447607600007

Keywords in English

B-cell lymphoma; Lupus-related single nucleotide polymorphisms

Tags

Tags

International impact, Reviewed
Změněno: 20/5/2022 10:50, Mgr. Tereza Miškechová

Abstract

V originále

Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.