Novel domino synthesis of 2-(2,3.4-substituted phenyl)
quinazolin-4-amine

J 2022

Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine

FATHALLA, Walid, Pavel PAZDERA, Mohamed E. KHALIFA, Ibrahim A. I. ALI, Samir M. EL RAYES et. al.

Základní údaje

Originální název

Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine

Autoři

FATHALLA, Walid, Pavel PAZDERA (203 Česká republika, domácí), Mohamed E. KHALIFA, Ibrahim A. I. ALI a Samir M. EL RAYES

Vydání

Journal of Heterocyclic Chemistry, Hoboken, Wiley, 2022, 0022-152X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10401 Organic chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.400

Kód RIV

RIV/00216224:14310/22:00125879

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1002/jhet.4435

UT WoS

000741461000001

Klíčová slova anglicky

2-arylquinazolin-4-amines; benzimidoyl isothiocyanic acid derivative; isothiocyanic acid derivative; quinazoline derivative; thiourea derivative

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 5. 2022 10:17, Mgr. Marie Šípková, DiS.

Anotace

V originále

Convenient domino protocol was developed for the synthesis of 2-arylquinazolin-4-amines by the reaction of N-(2-cyanophenyl) substituted benzimidoyl isothiocyanates with isopropyl amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives.

Citovat

FATHALLA, Walid, Pavel PAZDERA, Mohamed E. KHALIFA, Ibrahim A. I. ALI a Samir M. EL RAYES. Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine. Journal of Heterocyclic Chemistry. Hoboken: Wiley, 2022, roč. 59, č. 5, s. 933-942. ISSN 0022-152X. Dostupné z: https://dx.doi.org/10.1002/jhet.4435.

@article{1855738,
   author = {Fathalla, Walid and Pazdera, Pavel and Khalifa, Mohamed E. and Ali, Ibrahim A. I. and El Rayes, Samir M.},
   article_location = {Hoboken},
   article_number = {5},
   doi = {http://dx.doi.org/10.1002/jhet.4435},
   keywords = {2-arylquinazolin-4-amines; benzimidoyl isothiocyanic acid derivative; isothiocyanic acid derivative; quinazoline derivative; thiourea derivative},
   language = {eng},
   issn = {0022-152X},
   journal = {Journal of Heterocyclic Chemistry},
   title = {Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/jhet.4435},
   volume = {59},
   year = {2022}
}

TY  - JOUR
ID  - 1855738
AU  - Fathalla, Walid - Pazdera, Pavel - Khalifa, Mohamed E. - Ali, Ibrahim A. I. - El Rayes, Samir M.
PY  - 2022
TI  - Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine
JF  - Journal of Heterocyclic Chemistry
VL  - 59
IS  - 5
SP  - 933-942
EP  - 933-942
PB  - Wiley
SN  - 0022152X
KW  - 2-arylquinazolin-4-amines
KW  - benzimidoyl isothiocyanic acid derivative
KW  - isothiocyanic acid derivative
KW  - quinazoline derivative
KW  - thiourea derivative
UR  - https://onlinelibrary.wiley.com/doi/10.1002/jhet.4435
N2  - Convenient domino protocol was developed for the synthesis of 2-arylquinazolin-4-amines by the reaction of N-(2-cyanophenyl) substituted benzimidoyl isothiocyanates with isopropyl amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives.
ER  -

FATHALLA, Walid, Pavel PAZDERA, Mohamed E. KHALIFA, Ibrahim A. I. ALI a Samir M. EL RAYES. Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine. \textit{Journal of Heterocyclic Chemistry}. Hoboken: Wiley, 2022, roč.~59, č.~5, s.~933-942. ISSN~0022-152X. Dostupné z: https://dx.doi.org/10.1002/jhet.4435.

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