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@article{1860073,
author = {Kubinec, Jan and Širůčková, Viktorie and Havlíčková, Jana and Kotek, Jan and Kubíček, Vojtěch and Lubal, Přemysl and Hermann, Petr},
article_number = {19},
doi = {http://dx.doi.org/10.1002/ejic.202200173},
keywords = {Aminopolycarboxylate ligands; Copper; Macrocyclic ligands; Nuclear medicine; Transition metal complexes},
language = {eng},
issn = {1434-1948},
journal = {European Journal of Inorganic Chemistry},
title = {Complexes of NOTA-Monoamides with CuII Ions: Structural, Equilibrium, and Kinetic Study},
url = {https://doi.org/10.1002/ejic.202200173},
volume = {2022},
year = {2022}
}
TY - JOUR
ID - 1860073
AU - Kubinec, Jan - Širůčková, Viktorie - Havlíčková, Jana - Kotek, Jan - Kubíček, Vojtěch - Lubal, Přemysl - Hermann, Petr
PY - 2022
TI - Complexes of NOTA-Monoamides with CuII Ions: Structural, Equilibrium, and Kinetic Study
JF - European Journal of Inorganic Chemistry
VL - 2022
IS - 19
SP - 1-11
EP - 1-11
PB - Wiley-VCH GmbH
SN - 14341948
KW - Aminopolycarboxylate ligands
KW - Copper
KW - Macrocyclic ligands
KW - Nuclear medicine
KW - Transition metal complexes
UR - https://doi.org/10.1002/ejic.202200173
N2 - NOTA monoamides are commonly and widely used chelators for the complexation of copper radioisotopes applied in molecular imaging and targeted nuclear therapy. However, information about their coordination behavior remains scarce. In this study, two NOTA-monoamides, N-ethyl (H2L1) and N,N-diethyl (H2L2), were synthesized as model ligands and tested to probe differences in their coordination behavior between the secondary and tertiary amide pendant arms for potential applications as copper radioisotope carriers. Our results demonstrated that the solid [Cu(L1)] and [Cu(L2)] complex have a distorted octahedral arrangement, similar to structure of the [Cu(Hnota)] complex. As shown by equilibrium data, the ligands have a slightly lower basicity, and thus complexes with divalent metal ions and LiI have slightly lower stability constants than those of the parent ligand, H3nota. The dissociation constants of the CuII, ZnII and NiII complexes with H2L1 also indicate deprotonation and N-coordination of the secondary amide group at pH>9. Complexation of CuII ions with the title ligands is slower than that with H3nota but still very fast (quantitative binding in <1 s, pH 2, millimolar concentrations), and CuII complexes of both monoamide ligands are more resistant to acid-assisted decomplexation than the CuII-H3nota complex. Therefore, our coordination data highlight that NOTA-monoamides are suitable chelators for molecular imaging and nuclear medicine.
ER -
KUBINEC, Jan, Viktorie ŠIRŮČKOVÁ, Jana HAVLÍČKOVÁ, Jan KOTEK, Vojtěch KUBÍČEK, Přemysl LUBAL and Petr HERMANN. Complexes of NOTA-Monoamides with CuII Ions: Structural, Equilibrium, and Kinetic Study. \textit{European Journal of Inorganic Chemistry}. Wiley-VCH GmbH, 2022, vol.~2022, No~19, p.~1-11. ISSN~1434-1948. Available from: https://dx.doi.org/10.1002/ejic.202200173.
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