The Bisphenols Found in the Ejaculate of Men Does Not Pass
through the Testes

J 2022

The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes

JEŠETA, Michal, Kateřina FRANZOVÁ, Simona MACHYNOVÁ, Jiří KALINA, Jiří KOHOUTEK et. al.

Základní údaje

Originální název

The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes

Autoři

JEŠETA, Michal (203 Česká republika, domácí), Kateřina FRANZOVÁ (203 Česká republika, domácí), Simona MACHYNOVÁ (203 Česká republika), Jiří KALINA (203 Česká republika, domácí), Jiří KOHOUTEK (203 Česká republika, domácí), Lenka MEKIŇOVÁ (703 Slovensko, domácí), Igor CRHA (203 Česká republika, domácí), Bartosz KEMPISTY (616 Polsko), Marek KAŠÍK (203 Česká republika, domácí), Jana ŽÁKOVÁ (203 Česká republika, domácí), Pavel VENTRUBA (203 Česká republika, domácí) a Jana NAVRÁTILOVÁ (203 Česká republika, domácí)

Vydání

Toxics, Basel, MDPI, 2022, 2305-6304

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30108 Toxicology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.600

Kód RIV

RIV/00216224:14110/22:00126027

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/toxics10060311

UT WoS

000818158700001

Klíčová slova anglicky

bisphenol A; bisphenol S; bisphenol F; endocrine disruptors; human; spermatozoa; IVF; vasectomy; biotransformation

Štítky

14110225, 14110411, 14110611, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 1. 2023 14:13, Mgr. Marie Šípková, DiS.

Anotace

V originále

Exposure to bisphenols is related to negative effects on male reproduction. The bisphenols exposure is associated with several modes of action including negative impact on the blood–testis barrier (BTB) in testes or direct effect on spermatozoa. Bisphenols have been detected in human seminal plasma, but the possible mechanism of seminal transfer of bisphenols is not clear. Some authors consider the transfer through the blood–testis barrier to be crucial. Therefore, in this work, we compared normozoospermic men and men after vasectomy who have interrupted vas deferens and their ejaculate does not contain testicular products. We measured the concentration of bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) in the urine and seminal plasma of these men using liquid chromatography tandem mass spectrometry (LC/MSMS). We found that the ratio of urinary and seminal plasma content of bisphenols did not differ in normozoospermic men or men after vasectomy. From the obtained data, it can be concluded that the pathways of transport of bisphenols into seminal plasma are not primarily through the testicular tissue, but this pathway is applied similarly to other routes of transmission by a corresponding ejaculate volume ratio. To a much greater extent than through testicular tissue, bisphenols enter the seminal plasma mainly as part of the secretions of the accessory glands.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

EF19_074/0012727, projekt VaV

Název: MSCAfellow3@MUNI

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

Citovat

JEŠETA, Michal, Kateřina FRANZOVÁ, Simona MACHYNOVÁ, Jiří KALINA, Jiří KOHOUTEK, Lenka MEKIŇOVÁ, Igor CRHA, Bartosz KEMPISTY, Marek KAŠÍK, Jana ŽÁKOVÁ, Pavel VENTRUBA a Jana NAVRÁTILOVÁ. The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes. Toxics. Basel: MDPI, 2022, roč. 10, č. 6, s. 1-9. ISSN 2305-6304. Dostupné z: https://dx.doi.org/10.3390/toxics10060311.

@article{1860558,
   author = {Ješeta, Michal and Franzová, Kateřina and Machynová, Simona and Kalina, Jiří and Kohoutek, Jiří and Mekiňová, Lenka and Crha, Igor and Kempisty, Bartosz and Kašík, Marek and Žáková, Jana and Ventruba, Pavel and Navrátilová, Jana},
   article_location = {Basel},
   article_number = {6},
   doi = {http://dx.doi.org/10.3390/toxics10060311},
   keywords = {bisphenol A; bisphenol S; bisphenol F; endocrine disruptors; human; spermatozoa; IVF; vasectomy; biotransformation},
   language = {eng},
   issn = {2305-6304},
   journal = {Toxics},
   title = {The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes},
   url = {https://www.mdpi.com/2305-6304/10/6/311},
   volume = {10},
   year = {2022}
}

TY  - JOUR
ID  - 1860558
AU  - Ješeta, Michal - Franzová, Kateřina - Machynová, Simona - Kalina, Jiří - Kohoutek, Jiří - Mekiňová, Lenka - Crha, Igor - Kempisty, Bartosz - Kašík, Marek - Žáková, Jana - Ventruba, Pavel - Navrátilová, Jana
PY  - 2022
TI  - The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes
JF  - Toxics
VL  - 10
IS  - 6
SP  - 1-9
EP  - 1-9
PB  - MDPI
SN  - 23056304
KW  - bisphenol A
KW  - bisphenol S
KW  - bisphenol F
KW  - endocrine disruptors
KW  - human
KW  - spermatozoa
KW  - IVF
KW  - vasectomy
KW  - biotransformation
UR  - https://www.mdpi.com/2305-6304/10/6/311
N2  - Exposure to bisphenols is related to negative effects on male reproduction. The bisphenols exposure is associated with several modes of action including negative impact on the blood–testis barrier (BTB) in testes or direct effect on spermatozoa. Bisphenols have been detected in human seminal plasma, but the possible mechanism of seminal transfer of bisphenols is not clear. Some authors consider the transfer through the blood–testis barrier to be crucial. Therefore, in this work, we compared normozoospermic men and men after vasectomy who have interrupted vas deferens and their ejaculate does not contain testicular products. We measured the concentration of bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) in the urine and seminal plasma of these men using liquid chromatography tandem mass spectrometry (LC/MSMS). We found that the ratio of urinary and seminal plasma content of bisphenols did not differ in normozoospermic men or men after vasectomy. From the obtained data, it can be concluded that the pathways of transport of bisphenols into seminal plasma are not primarily through the testicular tissue, but this pathway is applied similarly to other routes of transmission by a corresponding ejaculate volume ratio. To a much greater extent than through testicular tissue, bisphenols enter the seminal plasma mainly as part of the secretions of the accessory glands.
ER  -

JEŠETA, Michal, Kateřina FRANZOVÁ, Simona MACHYNOVÁ, Jiří KALINA, Jiří KOHOUTEK, Lenka MEKIŇOVÁ, Igor CRHA, Bartosz KEMPISTY, Marek KAŠÍK, Jana ŽÁKOVÁ, Pavel VENTRUBA a Jana NAVRÁTILOVÁ. The Bisphenols Found in the Ejaculate of Men Does Not Pass through the Testes. \textit{Toxics}. Basel: MDPI, 2022, roč.~10, č.~6, s.~1-9. ISSN~2305-6304. Dostupné z: https://dx.doi.org/10.3390/toxics10060311.

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